Skip to Main content Skip to Navigation
Journal articles

Radiation-induced PGE 2 sustains human glioma cell growth and survival through EGF signaling

Abstract : Glioblastoma Multiforme (GBM) is the most common brain cancer in adults. Radiotherapy (RT) is the most effective post-operative treatment for the patients even though GBM is one of the most radio-resistant tumors. Dead or dying cells within the tumor are thought to promote resistance to treatment through mechanisms that are very poorly understood. We have evaluated the role of Prostaglandin E2 (PGE2), a versatile bioactive lipid, in GBM radio-resistance. We used an in vitro approach using 3D primary cultures derived from representative GBM patients. We show that irradiated glioma cells produced and released PGE2 in important quantities independently of the induction of cell death. We demonstrate that the addition of PGE2 enhances cell survival and proliferation though its ability to trans-activate the Epithelial Growth Factor receptor (EGFR) and to activate β-catenin. Indeed, PGE2 can substitute for EGF to promote primary cultures survival and growth in vitro and the effect is likely to occur though the Prostaglandin E2 receptor EP2.
Document type :
Journal articles
Complete list of metadatas

Cited literature [34 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-02914000
Contributor : Elizabeth Bernardo <>
Submitted on : Tuesday, August 11, 2020 - 9:29:24 AM
Last modification on : Wednesday, August 12, 2020 - 3:31:13 AM

File

3160-43043-3-PB.pdf
Publisher files allowed on an open archive

Identifiers

Collections

Citation

Emeline Brocard, Kristell Oizel, Lisenn Lalier, Claire Pecqueur, François Paris, et al.. Radiation-induced PGE 2 sustains human glioma cell growth and survival through EGF signaling. Oncotarget, Impact journals, 2015, 6 (9), pp.6840-6849. ⟨10.18632/oncotarget.3160⟩. ⟨inserm-02914000⟩

Share

Metrics

Record views

27

Files downloads

27