Radiation-induced PGE 2 sustains human glioma cell growth and survival through EGF signaling - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Oncotarget Année : 2015

Radiation-induced PGE 2 sustains human glioma cell growth and survival through EGF signaling

Résumé

Glioblastoma Multiforme (GBM) is the most common brain cancer in adults. Radiotherapy (RT) is the most effective post-operative treatment for the patients even though GBM is one of the most radio-resistant tumors. Dead or dying cells within the tumor are thought to promote resistance to treatment through mechanisms that are very poorly understood. We have evaluated the role of Prostaglandin E2 (PGE2), a versatile bioactive lipid, in GBM radio-resistance. We used an in vitro approach using 3D primary cultures derived from representative GBM patients. We show that irradiated glioma cells produced and released PGE2 in important quantities independently of the induction of cell death. We demonstrate that the addition of PGE2 enhances cell survival and proliferation though its ability to trans-activate the Epithelial Growth Factor receptor (EGFR) and to activate β-catenin. Indeed, PGE2 can substitute for EGF to promote primary cultures survival and growth in vitro and the effect is likely to occur though the Prostaglandin E2 receptor EP2.

Domaines

Cancer
Fichier principal
Vignette du fichier
3160-43043-3-PB.pdf (5.56 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...

Dates et versions

inserm-02914000 , version 1 (11-08-2020)

Identifiants

Citer

Emeline Brocard, Kristell Oizel, Lisenn Lalier, Claire Pecqueur, François Paris, et al.. Radiation-induced PGE 2 sustains human glioma cell growth and survival through EGF signaling. Oncotarget, 2015, 6 (9), pp.6840-6849. ⟨10.18632/oncotarget.3160⟩. ⟨inserm-02914000⟩
29 Consultations
25 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More