Skip to Main content Skip to Navigation
Journal articles

Universal scaling laws rule explosive growth in human cancers

Abstract : Most physical and other natural systems are complex entities that are composed of a large number of interacting individual elements. It is a surprising fact that they often obey the so-called scaling laws that relate an observable quantity to a measure of the size of the system. Here, we describe the discovery of universal superlinear metabolic scaling laws in human cancers. This dependence underpins increasing tumour aggressiveness, owing to evolutionary dynamics, that leads to an explosive growth as the disease progresses. We validated this dynamic using longitudinal volumetric data of different histologies from large cohorts of patients with cancer. To explain our observations we tested complex, biologically inspired mathematical models that describe the key processes that govern tumour growth. Our models predict that the emergence of superlinear allometric scaling laws is an inherently three-dimensional phenomenon. Moreover, the scaling laws that we identified allowed us to define a set of metabolic metrics with prognostic value, which adds clinical utility to our findings.
Document type :
Journal articles
Complete list of metadatas

https://www.hal.inserm.fr/inserm-02913972
Contributor : Elizabeth Bernardo <>
Submitted on : Tuesday, August 11, 2020 - 8:20:41 AM
Last modification on : Tuesday, August 18, 2020 - 3:25:14 AM

Identifiers

Collections

Citation

Victor Pérez-García, Gabriel Calvo, Jesús Bosque, Odelaisy León-Triana, Juan Jiménez, et al.. Universal scaling laws rule explosive growth in human cancers. Nature Physics, Nature Publishing Group, 2020, Online ahead of print. ⟨10.1038/s41567-020-0978-6⟩. ⟨inserm-02913972⟩

Share

Metrics

Record views

50