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Journal articles
Vorinostat for Refractory or Relapsing Epidermotropic T-cell Lymphoma: A Retrospective Cohort Study of 15 Patients
Abstract : Since the approval of vorinostat for the treatment of refractory cutaneous epidermotropic T-cell lymphoma (CTCL) in 2006, very little data about this treatment have been published. The aim of this retrospective study was to assess the efficacy and safety of vorinostat in patients with CTCL treated between 2007 and 2013 in our department. Fifteen patients (median age 64 years) were included: 9 with Sézary syndrome and 6 with mycosis fungoides. They were all in progression and the median number of systemic treatments previously administered was 3 (range 1-7). With vorinostat treatment, the best response was partial remission in 5 patients (33%) and stabilization in 4 patients (27%). Six patients experienced disease progression. The mean time to response and response duration were 70 (range 31-140) and 300 days (range 157-663) , respectively. The most frequent adverse events were asthenia, weight loss, nausea and anaemia. Vorinostat could be a therapeutic alternative for CTCL after treatment failure.
Cited literature [22 references]
https://www.hal.inserm.fr/inserm-02913574
Contributor : Elizabeth Bernardo Connect in order to contact the contributor
Submitted on : Monday, August 10, 2020 - 8:34:44 AM
Last modification on : Wednesday, November 10, 2021 - 3:32:04 PM
Long-term archiving on: : Monday, November 30, 2020 - 5:01:42 PM
Contributor : Elizabeth Bernardo Connect in order to contact the contributor
Submitted on : Monday, August 10, 2020 - 8:34:44 AM
Last modification on : Wednesday, November 10, 2021 - 3:32:04 PM
Long-term archiving on: : Monday, November 30, 2020 - 5:01:42 PM