C. P. Addington, J. M. Heffernan, C. S. Millar-haskell, E. W. Tucker, R. W. Sirianni et al., Enhancing neural stem cell response to SDF-1alpha gradients through hyaluronic acid-laminin hydrogels, Biomaterials, vol.72, pp.11-19, 2015.

A. C. Bellail, S. B. Hunter, D. J. Brat, C. Tan, and E. G. Van-meir, Microregional extracellular matrix heterogeneity in brain modulates glioma cell invasion, The International Journal of Biochemistry & Cell Biology, vol.36, issue.6, pp.1046-1069, 2004.

B. A. Bladergroen, B. Siebum, K. G. Siebers-vermeulen, T. H. Van-kuppevelt, A. A. Poot et al., In vivo recruitment of hematopoietic cells using stromal cell-derived factor 1 alpha-loaded heparinized three-dimensional collagen scaffolds, Tissue Engineering Part A, vol.15, issue.7, pp.1591-1599, 2009.

R. Boni, A. Ali, A. Shavandi, and A. N. Clarkson, Current and novel polymeric biomaterials for neural tissue engineering, Journal of Biomedical Science, vol.25, issue.1, pp.1-21, 2018.

X. Chen, W. Li, and T. Yu, Conformation transition of silk fibroin induced by blending chitosan, Journal of Polymer Science: Part B: Polymer Physics, vol.35, pp.2293-2296, 1997.

K. J. Christie and A. M. Turnley, Regulation of endogenous neural stem/progenitor cells for neural repair-Factors that promote neurogenesis and gliogenesis in the normal and damaged brain, Frontiers in Cellular Neuroscience, vol.6, pp.1-18, 2013.

C. R. Correia, L. S. Moreira-teixeira, L. Moroni, R. L. Reis, C. A. Van-blitterswijk et al., Chitosan Scaffolds containing hyaluronic acid for cartilage tissue engineering, Tissue Engineering Part C: Methods, vol.17, issue.7, pp.717-730, 2011.

D. Souza, S. W. Dobbing, and J. , Cerebral edema in developing brain: i. Normal water and cation content in developing rat brain and postmortem changes, Experimental Neurology, vol.32, pp.431-438, 1971.

A. Dehqan-niri, A. A. Karimi-zarchi, P. Ghadiri-harati, A. Salimi, and B. Mujokoro, Tissue engineering scaffolds in the treatment of brain disorders in geriatric patients, Artificial Organs, pp.1-14, 2019.

D. Dutta, C. Fauer, H. L. Mulleneux, and S. E. Stabenfeldt, Tunable controlled release of bioactive SDF-1? via specific protein interactions within fibrin/nanoparticle composites, Journal of Materials Chemistry B, vol.3, issue.40, pp.7963-7973, 2015.

D. Dutta, K. Hickey, M. Salifu, C. Fauer, C. Willingham et al., Spatiotemporal presentation of exogenous SDF-1 with PLGA nanoparticles modulates SDF-1/CXCR4 signaling axis in the rodent cortex, Biomaterials Science, vol.5, issue.8, pp.1640-1651, 2017.

A. J. Engler, S. Sen, H. L. Sweeney, and D. E. Discher, Matrix elasticity directs stem cell lineage specification, Cell, vol.126, issue.4, pp.677-689, 2006.

C. W. Foo, E. Bini, J. Hensman, D. P. Knight, R. V. Lewis et al., Role of pH and charge on silk protein assembly in insects and spiders, Applied Physics A: Materials Science and Processing, vol.82, issue.2, pp.223-233, 2006.

G. I. Frost, T. B. Csoka, T. Wong, and R. Stern, Purification, cloning, and expression of human plasma hyaluronidase, Biochemical and Biophysical Research Communications, vol.236, pp.10-15, 1997.

T. Führmann, J. Obermeyer, C. H. Tator, and M. S. Shoichet, Click-crosslinked injectable hyaluronic acid hydrogel is safe and biocompatible in the intrathecal space for ultimate use in regenerative strategies of the injured spinal cord, Methods, vol.84, pp.60-69, 2015.

M. Garcia-fuentes, E. Giger, L. Meinel, and H. P. Merkle, The effect of hyaluronic acid on silk fibroin conformation, Biomaterials, vol.29, issue.6, pp.633-642, 2008.

M. Garcia-fuentes, A. J. Meinel, M. Hilbe, L. Meinel, and H. P. Merkle, Silk fibroin/hyaluronan scaffolds for human mesenchymal stem cell culture in tissue engineering, Biomaterials, vol.30, issue.28, pp.5068-5076, 2009.

C. A. García-gonzález, T. Budtova, L. Durães, C. Erkey, P. Del-gaudio et al., An opinion paper on aerogels for biomedical and environmental applications, Molecules, vol.24, p.1815, 2019.

D. González-nieto, L. Fernández-garcía, J. Pérez-rigueiro, G. V. Guinea, and F. Panetsos, Hydrogels-assisted cell engraftment for repairing the stroke-damaged brain: Chimera or reality, Polymers, vol.10, 2018.

M. Haji-mansor, M. Najberg, A. Contini, C. Alvarez-lorenzo, E. Garcion et al., Development of a non-toxic and non-denaturing formulation process for encapsulation of SDF-1? into PLGA/PEG-PLGA nanoparticles to achieve sustained release, European Journal of Pharmaceutics and Biopharmaceutics, vol.125, pp.38-50, 2018.

A. P. Haring, E. G. Thompson, Y. Tong, S. Laheri, E. Cesewski et al., Process-and bio-inspired hydrogels for 3D bioprinting of soft free-standing neural and glial tissues, Biofabrication, vol.11, issue.2, 2019.

X. Hu, D. Kaplan, and P. Cebe, Determining beta-sheet crystallinity in fibrous proteins by thermal analysis and infrared spectroscopy, Macromolecules, vol.39, issue.18, pp.6161-6170, 2006.

X. Hu, K. Shmelev, L. Sun, E. S. Gil, S. H. Park et al., Regulation of silk material structure by temperature-controlled water vapor annealing, Biomacromolecules, vol.12, issue.5, pp.1686-1696, 2011.

Y. Hu, J. Ran, Z. Zheng, Z. Jin, X. Chen et al., Exogenous stromal derived factor-1 releasing silk scaffold combined with intra-articular injection of progenitor cells promotes bone-ligament-bone regeneration, Acta Biomaterialia, vol.71, pp.168-183, 2018.

J. Imitola, K. Raddassi, K. I. Park, F. Mueller, M. Nieto et al., Directed migration of neural stem cells to sites of CNS injury by the stromal cellderived factor 1 /CXC chemokine receptor 4 pathway, Proceedings of the National Academy of Sciences, vol.101, issue.52, pp.18117-18122, 2004.

W. H. Jian, H. C. Wang, C. H. Kuan, M. H. Chen, H. C. Wu et al., Glycosaminoglycan-based hybrid hydrogel encapsulated with polyelectrolyte complex nanoparticles for endogenous stem cell regulation in central nervous system regeneration, Biomaterials, vol.174, pp.17-30, 2018.

M. Jurga, M. B. Dainiak, A. Sarnowska, A. Jablonska, A. Tripathi et al., The performance of laminin-containing cryogel scaffolds in neural tissue regeneration, Biomaterials, vol.32, issue.13, pp.3423-3434, 2011.

J. R. Krieger, M. E. Ogle, J. Mcfaline-figueroa, C. E. Segar, J. S. Temenoff et al., Spatially localized recruitment of anti-inflammatory monocytes by SDF-1?-releasing hydrogels enhances microvascular network remodeling, Biomaterials, vol.77, pp.280-290, 2016.

J. W. Kuo, D. A. Swarm, and G. D. Prestwich, Chemical modification of hyaluronic acid by carbodiimides, Bioconjugate Chemistry, vol.2, issue.4, pp.232-241, 1991.

N. Lassoued, J. Delarue, B. Launay, and C. Michon, Baked product texture: Correlations between instrumental and sensory characterization using Flash Profile, Journal of Cereal Science, vol.48, issue.1, pp.133-143, 2008.
URL : https://hal.archives-ouvertes.fr/hal-02665419

T. T. Lau and D. A. Wang, Stromal cell-derived factor-1 (SDF-1): Homing factor for engineered regenerative medicine, Expert Opinion on Biological Therapy, vol.11, issue.2, pp.189-197, 2011.

G. D. Mahumane, P. Kumar, L. C. Du-toit, Y. E. Choonara, and V. Pillay, 3D scaffolds for brain tissue regeneration: Architectural challenges, Biomaterials Science, vol.6, issue.11, pp.2812-2837, 2018.

Ö. Malay, O. Bayraktar, and A. Batigün, Complex coacervation of silk fibroin and hyaluronic acid, International Journal of Biological Macromolecules, vol.40, issue.4, pp.387-393, 2007.

Y. Martín-martín, L. Fernández-garcía, M. H. Sanchez-rebato, N. Marí-buyé, F. J. Rojo et al., Evaluation of neurosecretome from mesenchymal stem cells encapsulated in silk fibroin hydrogels, Scientific Reports, vol.9, issue.1, pp.1-15, 2019.

D. Mazia, G. Schatten, and W. Sale, Adhesion of cells to surfaces coated with polysine. Applications to electron microscopy, The Journal of Cell Biology, vol.66, issue.3, pp.198-200, 1975.

S. Mobini, M. Taghizadeh-jahed, M. Khanmohammadi, A. Moshiri, M. Naderi et al., Comparative evaluation of in vivo biocompatibility and biodegradability of regenerated silk scaffolds reinforced with/without natural silk fibers, Journal of Biomaterials Applications, vol.30, issue.6, pp.793-809, 2016.

M. Modo, Bioscaffold-induced brain tissue regeneration, Frontiers in Neuroscience, vol.13, 1156.

Y. Monneau, F. Arenzana-seisdedos, and H. Lortat-jacob, The sweet spot: How GAGs help chemokines guide migrating cells, Journal of Leukocyte Biology, vol.99, issue.6, pp.935-953, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01352726

M. C. Murphy, J. Huston, C. R. Jack, K. J. Glaser, A. Manduca et al., Decreased brain stiffness in Alzheimer's disease determined by magnetic resonance elastography, Journal of Magnetic Resonance Imaging, vol.34, issue.3, pp.494-498, 2011.

M. Najberg, M. Haji-mansor, F. Boury, C. Alvarez-lorenzo, and E. Garcion, Reversing the tumor target: Establishment of a tumor trap, Frontiers in Pharmacology, vol.10, pp.1-12, 2019.
URL : https://hal.archives-ouvertes.fr/hal-02895562

M. M. Nava, M. T. Raimondi, and R. Pietrabissa, Controlling self-renewal and differentiation of stem cells via mechanical cues, Journal of Biomedicine and Biotechnology, pp.1-12, 2012.

C. Nicholson and E. Syková, Extracellular space structure revealed by diffusion analysis, Trends in Neurosciences, vol.21, issue.98, pp.1261-1263, 1998.

K. Nultsch and O. Germershaus, Silk fibroin degumming affects scaffold structure and release of macromolecular drugs, European Journal of Pharmaceutical Sciences, vol.106, pp.254-261, 2017.

G. Orive, E. Anitua, J. L. Pedraz, and D. F. Emerich, Biomaterials for promoting brain protection, repair and regeneration, Nature Reviews Neuroscience, vol.10, issue.9, pp.682-692, 2009.

S. H. Park, E. S. Gil, H. Shi, H. J. Kim, K. Lee et al., Relationships between degradability of silk scaffolds and osteogenesis, Biomaterials, issue.24, pp.6162-6172, 2010.

S. Prokoph, E. Chavakis, K. R. Levental, A. Zieris, U. Freudenberg et al., Sustained delivery of SDF-1alpha from heparin-based hydrogels to attract circulating pro-angiogenic cells, Biomaterials, vol.33, issue.19, pp.4792-4800, 2012.

B. P. Purcell, J. A. Elser, A. Mu, K. B. Margulies, and J. A. Burdick, Synergistic effects of SDF-1? chemokine and hyaluronic acid release from degradable hydrogels on directing bone marrow derived cell homing to the myocardium, Biomaterials, vol.33, issue.31, pp.7849-7857, 2012.

S. Y. Rabbany, J. Pastore, M. Yamamoto, T. Miller, S. Rafii et al., Continuous delivery of stromal cell-derived factor-1 from alginate scaffolds accelerates wound healing, Cell Transplantation, vol.19, issue.4, pp.399-408, 2010.

D. N. Rockwood, R. C. Preda, T. Yücel, X. Wang, M. L. Lovett et al., Materials fabrication from Bombyx mori silk fibroin, Nature Protocols, vol.6, issue.10, pp.1612-1631, 2011.

E. Rouslahti, Brain extracellular matrix, Glycobiology, vol.6, issue.5, pp.489-492, 1996.

R. Sadir, F. Baleux, A. Grosdidier, A. Imberty, and H. Lortat-jacob, Characterization of the stromal cell-derived factor-1alpha-heparin complex, The Journal of Biological Chemistry, vol.276, issue.11, pp.8288-8296, 2001.
URL : https://hal.archives-ouvertes.fr/pasteur-00166877

N. Seyedhassantehrani, Y. Li, and L. Yao, Dynamic behaviors of astrocytes in chemically modified fibrin and collagen hydrogels, Integrative Biology (United Kingdom), vol.8, issue.5, pp.624-634, 2016.

A. E. Thurber, F. G. Omenetto, and D. L. Kaplan, In vivo bioresponses to silk proteins, Biomaterials, pp.145-157, 2015.

C. Vepari and D. L. Kaplan, Silk as biomaterial, Progress in Polymer Science, vol.100, issue.2, pp.130-134, 2012.

C. Wang, X. Tong, and F. Yang, Bioengineered 3D Brain tumor model to elucidate the effects of matrix stiffness on glioblastoma cell behavior using peg-based hydrogels, Molecular Pharmaceutics, vol.11, pp.2115-2125, 2014.

J. Weickenmeier, R. De-rooij, S. Budday, P. Steinmann, T. C. Ovaert et al., Brain stiffness increases with myelin content, Acta Biomaterialia, vol.42, pp.265-272, 2016.

Z. Wentao, H. Ya'nan, L. Jian, B. Kaipeng, S. Peng et al., In vitro biocompatibility study of a water-rinsed biomimetic silk porous scaffold with olfactory ensheathing cells, International Journal of Biological Macromolecules, vol.125, pp.526-533, 2019.

M. Xia, R. Huang, K. L. Witt, N. Southall, J. Fostel et al., Compound cytotoxicity profiling using quantitative high-throughput screening, vol.116, pp.284-291, 2008.

H. Yamada, H. Nakao, Y. Takasu, and K. Tsubouchi, Preparation of undegraded native molecular fibroin solution from silkworm cocoons, Materials Science and Engineering: C, vol.14, issue.1, pp.207-214, 2001.

J. W. Yang, Y. F. Zhang, C. Y. Wan, Z. Y. Sun, S. Nie et al., , 2015.

, Autophagy in SDF-1a-mediated DPSC migration and pulp regeneration, Biomaterials, vol.44, pp.11-23

W. Zhao, K. Jin, J. Li, X. Qiu, and S. Li, Delivery of stromal cell-derived factor 1? for in situ tissue regeneration, Journal of Biological Engineering, vol.11, issue.1, pp.1-12, 2017.