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Journal Articles Nature Communications Year : 2020

Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice

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Abstract

Breast cancer is the most common type of cancer worldwide and one of the major causes of cancer death in women. Epidemiological studies have established a link between night-shift work and increased cancer risk, suggesting that circadian disruption may play a role in carcinogenesis. Here, we aim to shed light on the effect of chronic jetlag (JL) on mammary tumour development. To do this, we use a mouse model of spontaneous mammary tumourigenesis and subject it to chronic circadian disruption. We observe that circadian disruption significantly increases cancer-cell dissemination and lung metastasis. It also enhances the stemness and tumour-initiating potential of tumour cells and creates an immunosuppressive shift in the tumour microenvironment. Finally, our results suggest that the use of a CXCR2 inhibitor could correct the effect of JL on cancer-cell dissemination and metastasis. Altogether, our data provide a conceptual framework to better understand and manage the effects of chronic circadian disruption on breast cancer progression.
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Dates and versions

inserm-02907177 , version 1 (27-07-2020)

Licence

Attribution - CC BY 4.0

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Eva Hadadi, William Taylor, Xiao-Mei Li, Yetki Aslan, Marthe Villote, et al.. Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice. Nature Communications, 2020, 11 (1), pp.3193. ⟨10.1038/s41467-020-16890-6⟩. ⟨inserm-02907177⟩
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