 |
Journal articles
Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice
Abstract : Breast cancer is the most common type of cancer worldwide and one of the major causes of cancer death in women. Epidemiological studies have established a link between night-shift work and increased cancer risk, suggesting that circadian disruption may play a role in carcinogenesis. Here, we aim to shed light on the effect of chronic jetlag (JL) on mammary tumour development. To do this, we use a mouse model of spontaneous mammary tumourigenesis and subject it to chronic circadian disruption. We observe that circadian disruption significantly increases cancer-cell dissemination and lung metastasis. It also enhances the stemness and tumour-initiating potential of tumour cells and creates an immunosuppressive shift in the tumour microenvironment. Finally, our results suggest that the use of a CXCR2 inhibitor could correct the effect of JL on cancer-cell dissemination and metastasis. Altogether, our data provide a conceptual framework to better understand and manage the effects of chronic circadian disruption on breast cancer progression.
Cited literature [98 references]
https://www.hal.inserm.fr/inserm-02907177
Contributor : Myriam Bodescot <>
Submitted on : Monday, July 27, 2020 - 12:09:34 PM
Last modification on : Wednesday, September 16, 2020 - 5:19:16 PM
Contributor : Myriam Bodescot <>
Submitted on : Monday, July 27, 2020 - 12:09:34 PM
Last modification on : Wednesday, September 16, 2020 - 5:19:16 PM
File
s41467-020-16890-6.pdf
Publication funded by an institution
Licence
Distributed under a Creative Commons Attribution 4.0 International License