What Are Mesenchymal Stromal Cells? Origin and Discovery of Mesenchymal Stromal Cells, Mesenchymal Stromal Cells as Tumor Stromal Modulators, pp.1-37, 2017. ,
Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement, Cytotherapy, vol.8, issue.4, pp.315-322, 2006. ,
Cardiomyocytes can be generated from marrow stromal cells in vitro, J Clin Invest, vol.103, issue.5, pp.697-705, 1999. ,
Adult bone marrow stromal cells differentiate into neural cells in vitro, Exp Neurol, vol.164, issue.2, pp.247-56, 2000. ,
Differentiation, cell fusion, and nuclear fusion during ex vivo repair of epithelium by human adult stem cells from bone marrow stroma, Proc Natl Acad Sci, vol.100, issue.5, pp.2397-402, 2003. ,
In vitro differentiation of human umbilical cord blood-derived mesenchymal stem cells into hepatocyte-like cells, Biochem Biophys Res Commun, vol.330, issue.4, pp.1153-61, 2005. ,
Critical role of tumor necrosis factor signaling in mesenchymal stem cell-based therapy for autoimmune and inflammatory diseases, Front Immunol, vol.9, p.1658, 2018. ,
Mesenchymal stem cell migration during bone formation and bone diseases therapy, Int J Mol Sci, vol.19, issue.8, 2018. ,
Tissue Engineering and Cell-Based Therapies for Fractures and Bone Defects, Front Bioeng Biotechnol, vol.6, issue.105, pp.1-23, 2018. ,
Haematopoietic stem cell activity and interactions with the niche, Nat Rev Mol Cell Biol, vol.20, issue.5, p.30745579, 2019. ,
Hematopoietic stem cells, their niche, and the concept of co-culture systems: A critical review, J Stem Cells, vol.10, issue.1, pp.13-31, 2015. ,
Three-dimensional ex vivo co-culture models of the leukaemic bone marrow niche for functional drug testing, Drug Discov Today, vol.21, issue.9, pp.1464-71, 2016. ,
Spheroid Culture of Mesenchymal Stem Cells, Stem Cells Int, p.9176357, 2016. ,
Recent advances in three-dimensional multicellular spheroid culture for biomedical research, Biotechnol J, vol.3, issue.9, pp.1172-84, 2008. ,
Scaffold-free culture of mesenchymal stem cell spheroids in suspension preserves multilineage potential, Cell Tissue Res, vol.347, issue.3, p.21833761, 2012. ,
Human Non-Hematopoietic CD271pos/CD140a-low/neg Bone Marrow Stroma Cells Fulfill Stringent Stem Cell Criteria in Serial Transplantations, Stem Cells Dev, vol.25, issue.21, pp.1652-1660, 2016. ,
Spheroid Coculture of Hematopoietic Stem/Progenitor Cells and Monolayer Expanded Mesenchymal Stem/Stromal Cells in Polydimethylsiloxane Microwells Modestly Improves In Vitro Hematopoietic Stem/Progenitor Cell Expansion, Tissue Eng Part C Methods, vol.23, issue.4, pp.200-218, 2017. ,
Dissecting the marrow microenvironment, Annals of the New York Academy of Sciences, pp.164-70, 1999. ,
Functionally and phenotypically distinct subpopulations of marrow stromal cells are fibroblast in origin and induce different fates in peripheral blood monocytes, Stem Cells Dev, vol.23, issue.7, pp.729-769, 2014. ,
Guidelines for the use and interpretation of assays for monitoring autophagy, Autophagy, vol.12, issue.1, pp.1-222, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-02486052
Reliable LC3 and p62 autophagy marker detection in formalin fixed paraffin embedded human tissue by immunohistochemistry, Eur J Histochem, vol.59, issue.2, p.2481, 2015. ,
Three-dimensional spheroid culture of human umbilical cord mesenchymal stem cells promotes cell yield and stemness maintenance, Cell Tissue Res, vol.360, issue.2, p.25749992, 2015. ,
Modeling tumor cell adaptations to hypoxia in multicellular tumor spheroids, J Exp Clin Cancer Res, vol.36, issue.1, p.102, 2017. ,
Methods: Using Three-Dimensional Culture (Spheroids) as an In Vitro Model of Tumour Hypoxia, Tumor microenvironment, pp.167-96, 2016. ,
Linking hypoxia, DNA damage and proliferation in multicellular tumor spheroids, BMC Cancer, vol.17, issue.1, pp.1-12, 2017. ,
Mimicking the functional hematopoietic stem cell niche in vitro: Recapitulation of marrow physiology by hydrogel-based three-dimensional cultures of mesenchymal stromal cells, Haematologica, vol.97, issue.5, pp.651-60, 2012. ,
Mesenchymal Stem Cells Support Migration, Extracellular Matrix Invasion, Proliferation, and Survival of Endothelial Cells In Vitro, Stem Cells, vol.25, issue.7, pp.1761-1769, 2007. ,
Carbonic anhydrase IX (CAIX) as a mediator of hypoxia-induced stress response in cancer cells, SubCellular Biochemistry, pp.255-69, 2014. ,
Hypoxia and Metabolic Properties of Hematopoietic Stem Cells, Antioxid Redox Signal, vol.20, issue.12, pp.1891-901, 2014. ,
New insights into intracellular locations and functions of heme oxygenase-1, Antioxidants Redox Signal, vol.20, issue.11, pp.1723-1765, 2014. ,
Bone marrow oxidative stress and specific antioxidant signatures in myelodysplastic syndromes, Blood Adv, vol.3, issue.24, pp.4271-4280, 2019. ,
Three-dimensional spheroid culture of human gingiva-derived mesenchymal stem cells enhances mitigation of chemotherapy-induced oral mucositis, Stem Cells Dev, vol.21, issue.6, pp.937-984, 2012. ,
Low oxygen atmosphere facilitates proliferation and maintains undifferentiated state of umbilical cord mesenchymal stem cells in an hypoxia inducible factor-dependent manner, Cytotherapy, vol.16, issue.7, pp.881-92, 2014. ,
Spheroid Mesenchymal Stem Cells and Mesenchymal Stem Cell-Derived Microvesicles: Two Potential Therapeutic Strategies, Stem Cells Dev, vol.25, issue.3, pp.203-216, 2016. ,
Evaluation of polyelectrolyte complex-based scaffolds for mesenchymal stem cell therapy in cardiac ischemia treatment, Acta Biomater, vol.10, issue.2, pp.901-912, 2014. ,
URL : https://hal.archives-ouvertes.fr/inserm-01053518
Transplantation of Cord Blood Mesenchymal Stem Cells as Spheroids Enhances Vascularization, Tissue Eng Part A, vol.18, pp.2138-2185, 2012. ,
Three-Dimensional Spheroid-Cultured Mesenchymal Stem Cells Devoid of Embolism Attenuate Brain Stroke Injury After Intra-Arterial Injection, Stem Cells Dev, vol.23, issue.9, pp.978-89, 2013. ,
3D spheroid culture enhances survival and therapeutic capacities of MSCs injected into ischemic kidney, J Cell Mol Med, vol.20, issue.7, pp.1203-1216, 2016. ,
Mesenchymal stem cell spheroids exhibit enhanced in-vitro and in-vivo osteoregenerative potential, BMC Biotechnol, vol.14, issue.105, pp.1-10, 2014. ,
Engineering injectable bone using bone marrow stromal cell aggregates, Stem Cells Dev, vol.20, issue.6, pp.989-99, 2011. ,
Properties and usefulness of aggregates of synovial mesenchymal stem cells as a source for cartilage regeneration, Arthritis Res Ther, vol.14, issue.3, p.136, 2012. ,
Bone regeneration in calvarial defects in a rat model by implantation of human bone marrow-derived mesenchymal stromal cell spheroids, J Mater Sci Mater Med, vol.26, issue.11, p.254, 2015. ,
Quantitative spatial analysis of haematopoiesis-regulating stromal cells in the bone marrow microenvironment by 3D microscopy, Nat Commun, vol.9, issue.1, 2018. ,
The microenvironment in human myeloid malignancies: emerging concepts and therapeutic implications, Blood, vol.129, issue.12, pp.1617-1643, 2017. ,
Investigating osteogenic differentiation in multiple myeloma using a novel 3D bone marrow niche model, Blood, vol.124, issue.22, pp.3250-3259, 2014. ,
Compaction, fusion, and functional activation of three-dimensional human mesenchymal stem cell aggregate, Tissue Eng Part A, vol.21, issue.9, pp.1705-1724, 2015. ,
Three-Dimensional Spheroid Culture Increases Exosome Secretion from Mesenchymal Stem Cells, Tissue Eng Regen Med, vol.15, issue.4, p.30603566, 2018. ,
Long term morphological characterization of mesenchymal stromal cells 3D spheroids built with a rapid method based on entry-level equipment, Cytotechnology, pp.1-12, 2016. ,
Autophagy and cell growth-the yin and yang of nutrient responses, J Cell Sci, vol.125, issue.10, pp.2359-68, 2012. ,
Human papillomavirus 16E6/ E7 activates autophagy via Atg9B and LAMP1 in cervical cancer cells, Cancer Med, vol.8, issue.9, pp.4404-4420, 2019. ,
The development of an immunohistochemical method to detect the autophagy-associated protein LC3-II in human tumor xenografts, Toxicol Pathol, vol.39, issue.3, pp.516-539, 2011. ,
Hypoxic Preconditioning of Mesenchymal Stem Cells with Subsequent Spheroid Formation Accelerates Repair of Segmental Bone Defects, Stem Cells, vol.36, issue.9, pp.1393-403, 2018. ,
The influence of spheroid formation of human adipose-derived stem cells on chitosan films on stemness and differentiation capabilities, Biomaterials, vol.33, issue.6, pp.1748-58, 2012. ,
Constitutive stabilization of hypoxiainducible factor alpha selectively promotes the self-renewal of mesenchymal progenitors and maintains mesenchymal stromal cells in an undifferentiated state, Exp Mol Med, vol.45, issue.9, pp.1-11, 2013. ,
Hypoxia enhances proliferation and tissue formation of human mesenchymal stem cells, Biochem Biophys Res Commun, vol.358, issue.3, pp.948-53, 2007. ,