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PERISCOPE: road towards effective control of pertussis

Dimitri Diavatopoulos 1 Kingston H.G. Mills 2 Kent Kester 3 Beate Kampmann 4, 5 Marcela Silerova 6 Ulrich Heininger 7 Jacques J.M. van Dongen 8 Robbert van Der Most 6 Martijn Huijnen 1 Emilio Siena 9 Nathalie Mielcarek 10 Martina Ochs 11 Philippe Denoël 6 Guy Berbers 12 Anne Marie Buisman 12 Marien I. de Jonge 1 Craig Fenwick 13 Andrew Gorringe 14 Qiushui He 15 Dominic Kelly 16 Roger Le Grand 17 Camille Locht 10 Francoise Mascart 18 Jussi Mertsola 15 Alberto Orfao 19 Giuseppe Pantaleo 13 Andrew J Pollard 16 Andrew Preston 20 Robert Read 21 Peter Sebo 22 Cecile van Els 12 Branislav Vecerek 22 Patricia Londoño-Hayes 11 Ronald de Groot 1 
Abstract : The resurgence and changing epidemiology of pertussis in high-income countries, the high infant mortality caused by pertussis in low-income countries, and the increasing morbidity in all age groups worldwide call for a concerted effort to both improve the current vaccines and develop new vaccines and vaccination strategies against pertussis. In this Personal View, we identify several key obstacles on the path to developing a durable solution for global control of pertussis. To systematically address these obstacles, the PERtussIS Correlates Of Protection Europe (PERISCOPE) Consortium was established in March, 2016. The objectives of this consortium are to increase scientific understanding of immunity to pertussis in humans induced by vaccines and infections, to identify biomarkers of protective immunity, and to generate technologies and infrastructure for the future development of improved pertussis vaccines. By working towards the accelerated licensure and implementation of novel, well tolerated, and effective pertussis vaccines, we hope to strengthen and stimulate further collaboration and transparency between the key stakeholders, including the public, the scientific community, public health institutes, regulatory authorities, and vaccine manufacturers.
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Dimitri Diavatopoulos, Kingston H.G. Mills, Kent Kester, Beate Kampmann, Marcela Silerova, et al.. PERISCOPE: road towards effective control of pertussis. The Lancet Infectious Diseases, New York, NY : Elsevier Science ; The Lancet Pub. Group, 2001-, 2019, 19 (5), pp.e179-e186. ⟨10.1016/s1473-3099(18)30646-7⟩. ⟨inserm-02904613⟩



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