Serum GFAP in multiple sclerosis: correlation with disease type and MRI markers of disease severity - Archive ouverte HAL Access content directly
Journal Articles Scientific Reports Year : 2020

Serum GFAP in multiple sclerosis: correlation with disease type and MRI markers of disease severity

(1, 2, 3) , (4, 5, 6) , (2, 7) , (1, 2) , (1, 2) , (2, 3) , (2, 3) , (2, 3) , (2, 3) , (4, 5, 6) , (4, 5, 6) , (8, 9) , (8, 9) , (8, 9) , (8, 9) , (2, 3) , (1, 2)
1
2
3
4
5
6
7
8
9

Abstract

Neurofilament light chain (NfL) has been demonstrated to correlate with multiple sclerosis disease severity as well as treatment response. Nevertheless, additional serum biomarkers are still needed to better differentiate disease activity from disease progression. The aim of our study was to assess serum glial fibrillary acid protein (s-GFAP) and neurofilament light chain (s-NfL) in a cohort of 129 multiple sclerosis (MS) patients. Eighteen primary progressive multiple sclerosis (PPMS) and 111 relapsing remitting MS (RRMS) were included. We showed that these 2 biomarkers were significantly correlated with each other (R = 0.72, p < 0.001). Moreover, both biomarkers were higher in PPMS than in RRMS even if multivariate analysis only confirmed this difference for s-GFAP (130.3 ± 72.8 pg/ml vs 83.4 ± 41.1 pg/ml, p = 0.008). Finally, s-GFAP was correlated with white matter lesion load and inversely correlated with WM and GM volume. Our results seem to confirm the added value of s-GFAP in the context of multiple sclerosis.
Fichier principal
Vignette du fichier
s41598-020-67934-2.pdf (1.07 Mo) Télécharger le fichier
Origin : Publication funded by an institution
Loading...

Dates and versions

inserm-02904593 , version 1 (22-07-2020)

Licence

Attribution - CC BY 4.0

Identifiers

Cite

Xavier Ayrignac, Emmanuelle Le Bars, Claire Duflos, Christophe Hirtz, Aleksandra Maleska Maceski, et al.. Serum GFAP in multiple sclerosis: correlation with disease type and MRI markers of disease severity. Scientific Reports, 2020, 10 (1), pp.10923. ⟨10.1038/s41598-020-67934-2⟩. ⟨inserm-02904593⟩
214 View
67 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More