Abstract : Exposure to fibrates leads to normalization of fatty acid oxidation (FAO) in fibroblasts from patients with myopathic forms of CPT2 deficiency or VLCAD deficiency. Correction of FAO is related to a drug-induced increase of residual enzyme activity, and this could provide a new treatment strategy for these disorders.
https://www.hal.inserm.fr/inserm-02896275 Contributor : Fatima DjouadiConnect in order to contact the contributor Submitted on : Friday, July 10, 2020 - 1:54:05 PM Last modification on : Friday, May 20, 2022 - 11:06:32 AM Long-term archiving on: : Monday, November 30, 2020 - 8:04:53 PM
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F. Djouadi, F. Aubey, D. Schlemmer, S. Gobin, P. Laforet, et al.. Potential of fibrates in the treatment of fatty acid oxidation disorders: Revival of classical drugs?. Journal of Inherited Metabolic Disease, Springer Verlag, 2006, 29 (2-3), pp.341-342. ⟨10.1007/s10545-006-0266-3⟩. ⟨inserm-02896275⟩