Potential of fibrates in the treatment of fatty acid oxidation disorders: Revival of classical drugs? - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Journal of Inherited Metabolic Disease Année : 2006

Potential of fibrates in the treatment of fatty acid oxidation disorders: Revival of classical drugs?

Résumé

Exposure to fibrates leads to normalization of fatty acid oxidation (FAO) in fibroblasts from patients with myopathic forms of CPT2 deficiency or VLCAD deficiency. Correction of FAO is related to a drug-induced increase of residual enzyme activity, and this could provide a new treatment strategy for these disorders.
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inserm-02896275 , version 1 (10-07-2020)

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F. Djouadi, F. Aubey, D. Schlemmer, S. Gobin, P. Laforet, et al.. Potential of fibrates in the treatment of fatty acid oxidation disorders: Revival of classical drugs?. Journal of Inherited Metabolic Disease, 2006, 29 (2-3), pp.341-342. ⟨10.1007/s10545-006-0266-3⟩. ⟨inserm-02896275⟩
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