, Data are the means ± SD. Differences between groups were analyzed by one-way analysis of variance (ANOVA) and the Fisher test

P. Rinaldo, D. Matern, M. J. Bennett, B. C. Smith, and J. M. Denu, Mechanism of human SIRT1 activation by resveratrol, Annu. Rev. Borra, vol.280, pp.17187-17195, 2002.

K. T. Howitz, K. J. Bitterman, H. Y. Cohen, D. W. Lamming, S. Lavu et al., Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan, Nature, vol.425, pp.191-196, 2003.

M. Kaeberlein, T. Mcdonagh, B. Heltweg, J. Hixon, E. A. Westman et al.,

A. Napper, R. Curtis, P. S. Distefano, and S. Fields, Substrate-specific activation of sirtuins by resveratrol, J. Biol. Chem, vol.280, pp.17038-17045, 2005.

B. Dasgupta and J. Milbrandt, Resveratrol stimulates AMP kinase activity in neurons, 2007.

, Proc. Natl. Acad. Sci. U S A, vol.104, pp.7217-7222

R. P. Mcandrew, Y. Wang, A. W. Mohsen, M. He, J. Vockley et al., , 2008.

, Structural basis for substrate fatty acyl chain specificity: crystal structure of human very-long-chain acyl-CoA dehydrogenase, J. Biol. Chem, vol.283, pp.9435-9443

A. C. Rufer, R. Thoma, J. Benz, M. Stihle, B. Gsell et al.,

O. Chomienne and M. Hennig, The crystal structure of carnitine palmitoyltransferase 2 and implications for diabetes treatment, Structure, vol.14, pp.713-723, 2006.

S. Gobin-limballe, R. P. Mcandrew, F. Djouadi, J. J. Kim, and J. Bastin, Compared effects of missense mutations in Very-Long-Chain Acyl-CoA Dehydrogenase deficiency: Combined analysis by structural, functional and pharmacological approaches, Biochim. Biophys. Acta, vol.1802, pp.478-484, 2010.

J. J. Smith, R. D. Kenney, D. J. Gagne, B. P. Frushour, W. Ladd et al.,

J. Song, G. Razvadauskaite, and A. V. Lynch, Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo, BMC. Syst. Biol, vol.3, p.31, 2009.

Z. Gerhart-hines, J. T. Rodgers, O. Bare, C. Lerin, S. H. Kim et al.,

Z. Wu and P. Puigserver, Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha, Embo. J, vol.26, pp.1913-1923, 2007.

J. T. Rodgers and P. Puigserver, Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1, Proc. Natl. Acad. Sci. U S A, vol.104, pp.12861-12866, 2007.

M. Okazaki, Y. Iwasaki, M. Nishiyama, T. Taguchi, M. Tsugita et al.,

M. Kambayashi, K. Hashimoto, and Y. Terada, PPARbeta/delta regulates the human SIRT1 gene transcription via Sp1, Endocr. J, vol.57, pp.403-413, 2010.

, kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha, Proc Natl Acad Sci U S A, vol.104, pp.12017-12022

J. C. Milne, P. D. Lambert, S. Schenk, D. P. Carney, J. J. Smith et al., Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes, Nature, vol.450, pp.712-716, 2007.

J. N. Feige, M. Lagouge, C. Canto, A. Strehle, S. M. Houten et al.,

C. Mataki, P. J. Elliott, and J. Auwerx, Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation, Cell Metab, vol.8, pp.347-358, 2008.
URL : https://hal.archives-ouvertes.fr/inserm-00350876

J. Bastin, F. Aubey, A. Rotig, A. Munnich, and F. Djouadi, Activation of peroxisome proliferator-activated receptor pathway stimulates the mitochondrial respiratory chain and can correct deficiencies in patients' cells lacking its components, J Clin Endocrinol Metab, vol.93, pp.1433-1441, 2008.