Monogenic mitochondrial disorders, N. Engl. J. Med, vol.366, pp.1132-1141, 2012. ,
Treatment for mitochondrial disorders, Cochrane Database Syst Rev, vol.4, p.4426, 2012. ,
The pharmacology of dichloroacetate, Metabolism, vol.38, pp.1124-1144, 1989. ,
Activation of peroxisome proliferator--activated receptor pathway stimulates the mitochondrial respiratory chain and can correct deficiencies in patients' cells lacking its components, J. Clin. Endocrinol. Metab, vol.93, pp.1433-1441, 2008. ,
A metabolic shift induced by a PPAR panagonist markedly reduces the effects of pathogenic mitochondrial tRNA mutations, J. Cell. Mol. Med, vol.15, pp.2317-2325, 2011. ,
,
In Vivo Correction of COX Deficiency by Activation of the AMPK/PGC--1alpha Axis, Cell. Metab, vol.14, pp.80-90, 2011. ,
Activation of the PPAR/PGC--. Metab, vol.8, pp.249-256, 2008. ,
Transcriptional integration of mitochondrial biogenesis, Trends Endocrinol. Metab, vol.23, pp.459-466, 2012. ,
Peroxisome proliferator--activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism, Endocr. Rev, vol.27, pp.728-735, 2006. ,
Regulation of PGC--1alpha, a nodal regulator of mitochondrial biogenesis, Am. J. Clin. Nutr, vol.93, pp.884-890, 2011. ,
,
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan, Nature, vol.425, pp.191-196, 2003. ,
Resveratrol ameliorates aging--related metabolic phenotypes by inhibiting cAMP phosphodiesterases, Cell, vol.148, pp.421-433, 2012. ,
,
SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function, Cell. Metab, vol.15, pp.675-690, 2012. ,
Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor, Proc. Natl. Acad. Sci. U S A, vol.94, pp.14138-14143, 1997. ,
Regulation of mitochondrial respiratory chain biogenesis by estrogens/estrogen receptors and physiological, pathological and pharmacological implications, Biochim. Biophys. Acta, vol.1793, pp.1540-1570, 2009. ,
Estrogen related receptors (ERRs): a new dawn in transcriptional control of mitochondrial gene networks, Mitochondrion, vol.11, pp.544-552, 2011. ,
Gas sensing in microplates with optodes: influence of oxygen exchange between sample, air, and plate material, 2005. ,
, Biotechnol. Bioeng, vol.90, pp.271-280
, , 2005.
, Microplates with integrated oxygen sensors for kinetic cell respiration measurement and cytotoxicity testing in primary and secondary cell lines, Assay Drug Dev. Technol, vol.3, pp.299-307
An integrated approach to improved toxicity prediction for the safety assessment during preclinical drug development using Hep G2 cells, Toxicol. Appl. Pharmacol, vol.237, pp.221-231, 2009. ,
Long time monitoring of the respiratory activity of isolated mitochondria, Exp. Cell. Res, vol.318, pp.1667-1672, 2012. ,
Lactic acidemia and mitochondrial disease, Mol. Genet. Metab, vol.89, pp.3-13, 2006. ,
Mitochondrial transcription factor A (TFAM): roles in maintenance of mtDNA and cellular functions, Mitochondrion, vol.7, pp.39-44, 2007. ,
Resveratrol improves health and survival of mice on a high--calorie diet, Nature, vol.444, pp.337-342, 2006. ,
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC--1alpha, Cell, vol.127, pp.1109-1122, 2006. ,
URL : https://hal.archives-ouvertes.fr/hal-00188005
,
Resveratrol induces mitochondrial biogenesis in endothelial cells, Am. J. Physiol. Heart Circ. Physiol, vol.297, pp.13-20, 2009. ,
Fortifying the link between SIRT1, resveratrol, and mitochondrial function, Cell Metab, vol.15, pp.566-567, 2012. ,
SIRT1 regulates hepatocyte lipid metabolism through activating AMP--activated protein kinase, J. Biol. Chem, vol.283, pp.20015-20026, 2008. ,
,
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity, Nature, vol.458, pp.1056-1060, 2009. ,
URL : https://hal.archives-ouvertes.fr/inserm-00383329
,
Negative regulation of STAT3 protein--mediated cellular respiration by SIRT1 protein, J. Biol. Chem, vol.286, pp.19270-19279, 2011. ,
Peroxisome Proliferator Activated Receptor {delta} (PPAR{delta}) Agonist But Not PPAR{alpha} Corrects Carnitine, 2005. ,
, Palmitoyl Transferase 2 Deficiency in Human Muscle Cells, J. Clin. Endocrinol. Metab, vol.90, pp.1791-1797
Correction of fatty acid oxidation in carnitine palmitoyl transferase 2--deficient cultured skin fibroblasts by bezafibrate, Pediatr. Res, vol.54, pp.446-451, 2003. ,
Sirtuin 1--mediated effects of exercise and resveratrol on mitochondrial biogenesis, J. Biol. Chem, vol.288, pp.6968-6979, 2013. ,
Resveratrol acts as a mixed agonist/antagonist for estrogen receptors alpha and beta, Endocrinology, vol.141, pp.3657-3667, 2000. ,
,
Oestrogens ameliorate mitochondrial dysfunction in Leber's hereditary optic neuropathy, Brain, vol.134, pp.220-234, 2011. ,
Estrogen prevents oxidative damage to the mitochondria in Friedreich's ataxia skin fibroblasts, PLoS One, vol.7, p.34600, 2012. ,
Resveratrol interacts with estrogen receptor--beta to inhibit cell replicative growth and enhance stress resistance by upregulating mitochondrial superoxide dismutase. Free Radic, Biol. Med, vol.50, pp.821-831, 2011. ,
, Regulation of PPARgamma coactivator, vol.1, p.PGC, 2004.
, signaling by an estrogen--related receptor alpha (ERRalpha) ligand, Proc. Natl. Acad. Sci
, , vol.101, pp.8912-8917
,
Erralpha and Gabpa/b specify PGC--1alpha--dependent oxidative phosphorylation gene expression that is altered in diabetic muscle, Proc. Natl. Acad. Sci, 2004. ,
, , vol.101, pp.6570-6575
Flavone and isoflavone phytoestrogens are agonists of estrogen--related receptors, Mol. Cancer Res, vol.1, pp.981-991, 2003. ,
Estrogen stimulates estrogen--related receptor alpha gene expression through conserved hormone response elements, 2003. ,
, Endocrinology, vol.144, pp.4894-4904
,
Calorie restriction--like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans, Cell Metab, vol.14, pp.612-622, 2011. ,
Exposure to resveratrol triggers pharmacological correction of fatty acid utilization in human fatty acid oxidation--deficient fibroblasts, Hum. Mol. Genet, vol.20, pp.2048-2057, 2011. ,
URL : https://hal.archives-ouvertes.fr/inserm-02894854
Enzymatic Analysis: a practical guide, 1993. ,
In vivo and in organello assessment of OXPHOS activities, Methods, vol.26, pp.307-316, 2002. ,
,
Large--scale deletion and point mutations of the nuclear NDUFV1 and NDUFS1 genes in mitochondrial complex I deficiency, 2001. ,
, J. Hum. Genet, vol.68, pp.1344-1352
,
High--throughput, pooled sequencing identifies mutations in NUBPL and FOXRED1 in human complex I deficiency, Nat. Genet, vol.42, pp.851-858, 2010. ,
The role of nuclear--encoded subunit genes in mitochondrial complex I deficiency. Thesis, 2005. ,
,
Mutant NDUFV2 subunit of mitochondrial complex I causes early onset hypertrophic cardiomyopathy and encephalopathy, Hum. Mutat, vol.21, pp.582-586, 2003. ,
,
Mutant NDUFS3 subunit of mitochondrial complex I causes Leigh syndrome, J. Med. Genet, vol.41, pp.14-17, 2004. ,
,
NDUFS6 mutations are a novel cause of lethal neonatal mitochondrial complex I deficiency, J. Clin. Invest, vol.114, pp.837-845, 2004. ,
,
A mitochondrial protein compendium elucidates complex I disease biology, Cell, vol.134, pp.112-123, 2008. ,
,
A mutation in the human heme A:farnesyltransferase gene (COX10 ) causes cytochrome c oxidase deficiency, Hum. Mol. Genet, vol.9, pp.1245-1249, 2000. ,
Mutations of SURF--1 in Leigh disease associated with cytochrome c oxidase deficiency, Am. J. Hum. Genet, vol.63, pp.1609-1621, 1998. ,
Mutations in SURF1 are not specifically associated with Leigh syndrome, J. Med. Genet, vol.38, pp.109-113, 2001. ,