Long-term expression of melanopsin and channelrhodopsin causes no gross alterations in the dystrophic dog retina - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Gene Therapy Année : 2017

Long-term expression of melanopsin and channelrhodopsin causes no gross alterations in the dystrophic dog retina

Résumé

Several preclinical studies have investigated the potential of algal channelrhodopsin and human melanopsin as optogenetic tools for vision restoration. In the present study, we assessed the potentially deleterious effects of long-term expression of these optogenes on the diseased retina in a large animal model of retinal degeneration, the RPE65-deficient Briard dog model of Leber congenital amaurosis. Intravitreal injection of adeno-associated virus vectors expressing channelrhodopsin and melanopsin had no effect on retinal thickness over a 16-month period post injection. Our data support the safety of the optogenetic approach for the treatment of blindness.
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inserm-02894245 , version 1 (08-07-2020)

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B Ameline, K-T Tshilenge, M. Weber, M. Biget, L Libeau, et al.. Long-term expression of melanopsin and channelrhodopsin causes no gross alterations in the dystrophic dog retina. Gene Therapy, 2017, 24 (11), pp.735-741. ⟨10.1038/gt.2017.63⟩. ⟨inserm-02894245⟩
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