Gene therapy restores vision in a canine model of childhood blindness, Nat. Genet, vol.28, issue.1, pp.92-97 ,
Long-term restoration of rod and cone vision by single dose rAAV-mediated gene transfer to the retina in a canine model of childhood blindness, Mol. Ther, vol.12, issue.6, pp.1072-82, 2005. ,
Pro)insulin and insulin-like growth factor I complementary expression and roles in early development, Comp. Biochem. Physiol. B. Biochem. Mol. Biol, vol.121, pp.13-17, 1998. ,
The role of PI 3-kinase in insulin action, Biochim. Biophys. Acta, vol.1436, pp.151-164, 1998. ,
, Retinal Degenerations: From Cell Signaling to Cell Therapy Current Gene Therapy, vol.7, issue.2, p.127, 2007.
Wnt-3a overcomes beta-amyloid toxicity in rat hippocampal neurons, Exp. Cell Res, vol.297, issue.1, pp.186-96, 2004. ,
Ciliary neurotrophic factor protects striatal output neurons in an animal model of Huntington disease, Proc. Natl. Acad. Sci. USA, vol.93, pp.7346-7351, 1996. ,
Physiological functions of thioredoxin and thioredoxin reductase, Eur. J. Biochem, vol.267, pp.6102-6109, 2000. ,
Preparation and assay of mammalian thioredoxin and thioredoxin reductase, Meth. Enzymol, vol.300, pp.226-239, 1999. ,
Insulin rescues retinal neurons from apoptosis by a phosphatidylinositol 3-kinase/AKT-mediated mechanism that reduces the activation of caspase-3, J. Biol. Chem, vol.276, pp.32814-32821, 2001. ,
Cell survival matters: docosahexaenoic acid signaling, neuroprotection and photoreceptors, Trends Neurosci, vol.29, issue.5, pp.263-71, 2006. ,
Immunolocalization of ciliary neurotrophic factor receptor (CNTFR ) in mammalian photoreceptor cells, Mol. Vis, vol.11, pp.232-244, 2005. ,
Photoreceptor cell rescue in retinal degeneration (rd1) mice by in vivo gene therapy, Nat. Med, vol.2, issue.6, pp.649-54, 1996. ,
Adenovirus-mediated delivery of rhodopsin-promoted bcl-2 results in a delay in photoreceptor cell death in the rd1 mouse, Gene Ther, vol.5, issue.9, pp.1156-64, 1998. ,
Immune response following intraocular delivery of recombinant viral vectors, Gene Ther, vol.10, issue.11, pp.977-82, 2003. ,
Early loss of synaptic protein PSD-95 from rod terminals of rhodopsin P347L transgenic porcine retina, Brain Res, vol.885, pp.53-61, 2000. ,
Effects of adeno-associated virus-vectored ciliary neurotrophic factor on retinal structure and function in mice with a P216L rds/peripherin mutation, Exp. Eye Res, vol.74, issue.6, pp.719-754, 2002. ,
Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors, J. Biol. Chem, vol.269, pp.11648-55, 1994. ,
Signaling specificity by Frizzled receptors in Drosophila, Science, vol.288, issue.5472, pp.1825-1833, 2000. ,
AAVmediated delivery of ciliary neurotrophic factor prolongs photoreceptor survival in the rhodopsin knockout mouse, Mol. Ther, vol.3, issue.2, pp.241-249, 2001. ,
Mechanical injury increases bFGF and CNTF mRNA expression in the mouse retina, Exp. Eye Res, vol.65, pp.241-248, 1997. ,
Differential effect of the rd1 mutation on rods and cones in the mouse retina, Invest. Ophthalmol. Vis. Sci, vol.17, issue.6, pp.489-98, 1978. ,
Differential proteomic analysis of the mouse retina: the induction of crystallin proteins by retinal degeneration in the rd1 mouse, Mol. Cell Proteomics, vol.2, issue.8, pp.494-505, 2003. ,
Adenovirus-mediated gene transfer of ciliary neurotrophic factor can prevent photoreceptor degeneration in the retinal degeneration (rd1) mouse. Hum, Gene Ther, vol.8, issue.4, pp.423-453, 1997. ,
Retinal degeneration mutants in the mouse Vision Res, vol.42, pp.517-542, 2002. ,
Apoptosis: final common pathway of photoreceptor death in rd1, rds, and rhodopsin mutant mice, Neuron, vol.11, issue.4, pp.595-605, 1993. ,
Repeated injections of a ciliary neurotrophic analog leading to long-term photoreceptor survival in retinal degeneration Invest, Ophthalmol. Vis. Sci, vol.40, pp.1298-1305, 1999. ,
Connexin 36 in photoreceptor cells: studies on transgenic rod-less and cone-less mouse retinas, Mol. Vis, vol.10, pp.323-330, 2004. ,
LIFR beta and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor, Science, vol.260, pp.1805-1813, 1993. ,
Inherited retinal degenerations: therapeutic prospects, Biol. Cell, vol.96, pp.261-270, 2004. ,
Evidence for glutamate-mediated excitotoxic mechanisms during photoreceptor degeneration in the rd1 mouse retina, Mol. Vis, vol.11, pp.688-696, 2005. ,
Transcription of photoreceptor genes during foetal retinal development. Evidence for positive and negative regulation, J. Biol. Chem, vol.268, pp.6953-6960, 1993. ,
Prolonged delivery of brain-derived neurotrophic factor by adenovirusinfected Muller cells temporarily rescues injured retinal ganglion cells, Proc. Natl. Acad. Sci. USA, vol.95, issue.7, pp.3978-83, 1998. ,
, Retinal cells and processing, 1987.
On the genetics of retinitis pigmentosa and on mutation-independent approaches to therapeutic intervention, EMBO J, vol.21, issue.5, pp.857-64, 2002. ,
Death receptor signaling and its function in the immune system, Curr. Dir. Autoimmun, vol.9, pp.1-17, 2006. ,
Cone neurite sprouting: An early onset abnormality of the cone photoreceptors in the retinal degeneration mouse, Mol. Vis, vol.8, pp.306-320, 2002. ,
Partial characterisation of retina-derived cone neuroprotection in two culture models of photoreceptor degeneration, IOVS, vol.44, pp.818-825, 2003. ,
Survival of purified rat photoreceptors in vitro is stimulated directly by fibroblast growth factor-2, J. Neurosci, vol.18, pp.9662-9672, 1998. ,
Survival of purified rat photoreceptors in. vitro is stimulated directly by fibroblast growth factor-2, J. Neurosci, vol.118, issue.23, pp.9662-72, 1998. ,
Insulinlike growth factor I stimulates neurogenesis in chick retina by regulating expression of the alpha 6 integrin subunit, Development, vol.122, pp.2497-2506, 1996. ,
Glial cell line-derived neurotrophic factor induces histological and functional protection of rod photoreceptors in the retinal degeneration [rd1] mouse. Invest. Ophthalmol, Vis. Sci, vol.40, pp.2724-2734, 1999. ,
Glial cell line-derived neurotrophic factor induces histologic and functional protection of rod photoreceptors in the rd1 mouse, Invest. Ophthalmol. Vis. Sci, vol.40, issue.11, pp.2724-2758, 1999. ,
Assessment of foveal cone photoreceptors in Stargardt's macular dystrophy using a small dot detection task, Vision Res, vol.33, issue.11, pp.1509-1533, 1993. ,
Two zebrafish mutants, ebony and ivory, uncover benefits of neighborhood on photoreceptor survival, J. Neurobiol, vol.57, pp.235-280, 2003. ,
Functional abnormalities in transgenic mice expressing a mutant rhodopsin gene, Invest. Ophthalmol. Vis. Sci, vol.36, issue.1, pp.62-71, 1995. ,
The Wnt signaling pathway in retinal degenerations, IUBMB Life, vol.57, issue.6, pp.381-389, 2005. ,
Identification of gene expression changes associated with the progression of retinal degeneration in the rd1 mouse, IOVS, vol.45, pp.2929-2942, 2004. ,
Ciliary neurotrophic factor prevents degeneration of adult rat substantia nigra dopaminergic neurons in vivo, Proc. Natl. Acad. Sci. USA, vol.90, pp.6315-6319, 1993. ,
Potential role of glial cell line-derived neurotrophic factor receptors in Muller glial cells during light-induced retinal degeneration, Neuroscience, vol.122, issue.1, pp.229-264, 2003. ,
Autocrine/panacrine role of insulin-related growth factors in neurogenesis: local expression and effects on cell proliferation and differentiation in the retina, Proc. Natl. Acad. Sci. USA, vol.92, pp.9834-9838, 1995. ,
Photoreceptor survival-promoting activity in interphotoreceptor matrix preparations: characterization and partial purification, Exp. Eye Res, vol.50, issue.1, pp.79-88, 1990. ,
Retinitis pigmentosa: genes, proteins and prospects, Dev. Ophthalmol, vol.37, pp.109-134, 2003. ,
Photoreceptor protection by iris pigment epithelial transplantation transduced with AAV-mediated brain-derived neurotrophic factor gene, Invest. Ophthalmol. Vis. Sci, vol.45, issue.10, pp.3721-3727, 2004. ,
Cellular interactions implicated in the mechanism of photoreceptor degeneration in transgenic mice expressing a mutant rhodopsin gene, Proc. Natl. Acad. Sci. USA, vol.90, issue.18, pp.8484-8492, 1993. ,
Cellular interactions implicated in the mechanism of photoreceptor degeneration in transgenic mice expressing a mutant rhodopsin gene, Proc. Natl. Acad. Sci. USA, vol.90, issue.18, pp.8484-8492, 1993. ,
Comparative structural and functional analysis of photoreceptor neurons of Rho-/-mice reveal increased survival on C57BL/6J in comparison to 129Sv genetic background, Vis. Neurosci, vol.18, issue.3, pp.437-480, 2001. ,
Loss of cone molecular markers in rhodopsin-mutant human retinas with retinitis pigmentosa, Mol. Vis, vol.6, pp.204-215, 2000. ,
Retinal remodeling during retinal degeneration Exper, Eye Res, vol.81, pp.123-137, 2005. ,
Expression of CNTF in Muller cells of the rat retina after pressure-induced ischemia, NeuroReport, vol.10, pp.419-422, 1999. ,
Insulin-like growth factor-I protects axotomised rat retinal ganglion cells from secondary death via PI3-K-dependent Akt phosphorylation and inhibition of caspase-3 in vivo, J. Neurosci, vol.20, pp.2-8, 2000. ,
Alternate FGF2-ERK1/2 signaling pathways in retinal photoreceptor and glial cells. in vitro, J. Biol. Chem, vol.276, pp.43871-43878, 2001. ,
Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light, Proc. Natl. Acad. Sci. USA, vol.89, pp.11249-11253, 1992. ,
Protection of mouse photoreceptors by survival factors in retinal degenerations, Invest. Ophthalmol. Vis. Sci, vol.39, issue.3, pp.592-602, 1998. ,
,
AAV-mediated expression of CNTF promotes long-term survival and regeneration of adult rat retinal ganglion cells, Gene Ther. Epub, 2006. ,
Efficiency of recombinant human TNF in human cancer therapy, Cancer Immun, vol.22, p.6, 2006. ,
Photoreceptor degeneration in inherited retinal dystrophy delayed by basic fibroblast growth factor, Nature, vol.347, issue.6288, pp.83-89, 1990. ,
Identification and characterization of rod-derived cone viability factor, Nat. Genet, vol.36, pp.755-764, 2004. ,
Long-term rescue of photoreceptor cells in the retinas of RCS dystrophic rats by RPE transplants, Prog. Brain Res, vol.82, pp.179-85, 1990. ,
Long-term protection of retinal structure but not function using RAAV.CNTF in animal models of retinitis pigmentosa, Mol. Ther, vol.4, issue.5, pp.461-72, 2001. ,
,
Purification, cloning, and expression of ciliary neurotrophic factor (CNTF), Science, vol.246, pp.1023-1025, 1989. ,
Retinal repair by transplantation of photoreceptor precursors, Nature, vol.444, issue.7116, pp.203-210, 2006. ,
Human alphaA-and al-phaB-crystallins bind to Bax and Bcl-X[S] to sequester their translocation during staurosporine-induced apoptosis, Cell Death Differ, vol.11, issue.5, pp.512-538, 2004. ,
Neural remodeling in retinal degeneration, Prog. Retin. Eye Res, vol.22, issue.5, pp.607-55, 2003. ,
Morphological and physiological consequences of the selective elimination of rod photoreceptors in transgenic mice, Exp. Eye Res, vol.63, issue.1, pp.35-50, 1996. ,
Glial cell line derived neurotrophic factor delays photoreceptor degeneration in a transgenic rat model of retinitis pigmentosa, Mol. Ther, vol.4, issue.6, pp.622-631, 2001. ,
DNA repair in the degenerating mouse retina, Mol. Cell Neurosci, vol.26, issue.3, pp.441-450, 2004. ,
Stable and efficient gene transfer into the retina using an HIV-based lentiviral vector, Proc. Natl. Acad. Sci. USA, vol.94, issue.19, pp.10319-10342, 1997. ,
Normal retina releases a diffusible factor stimulating cone survival in the retinal degeneration mouse Proc, Natl. Acad. Sci. USA, vol.95, p.83762, 1998. ,
Selective transplantation of rods delays cone loss in a retinitis pigmentosa model, Arch Ophthalmol, vol.118, pp.807-818, 2000. ,
Rod-cone interactions: developmental and clinical significance, Prog. Retin. Eye Res, vol.20, issue.4, pp.451-67, 2001. ,
Photoreceptor transplants increase host cone survival in the retinal degeneration (rd1) mouse, Ophthalmic. Res, vol.29, issue.5, pp.290-297, 1997. ,
Simulation of human autosomal dominant retinitis pigmentosa in transgenic mice expressing a mutated murine opsin gene, Proc. Natl. Acad. Sci. USA, vol.90, issue.12, pp.5499-503, 1993. ,
Growth factors in combination, but not individually, rescue rd1 mouse photoreceptors in organ culture, Exp. Neurol, vol.161, issue.2, pp.676-85, 2000. ,
Primary structure of chicken cone visual pigments: vertebrate rhodopsins have evolved out of cone visual pigments, Proc. Natl. Acad. Sci. USA, vol.89, pp.5932-5936, 1992. ,
Increased expression of brain-derived neurotrophic factor preserves retinal function and slows cell death from rhodopsin mutation or oxidative damage, J. Neurosci, vol.23, pp.4164-4172, 2003. ,
Truncated thioredoxin: physiological functions and mechanism, Antioxid. Redox. Signal, vol.6, issue.1, pp.53-61, 2004. ,
Ciliary Neurotrophic Factor and Stress Stimuli Activate the Jak-STAT Pathway in Retinal Neurons and Glia J. Neuroscience, vol.20, pp.4081-4090, 2000. ,
Genetically engineered large animal model for studying cone photoreceptor survival and degeneration in retinitis pigmentosa, Nat. Biotechnol, vol.15, issue.10, pp.965-70, 1997. ,
Apoptotic photoreceptor cell death in mouse models of retinitis pigmentosa, Proc. Natl. Acad. Sci. USA, vol.91, issue.3, pp.974-982, 1994. ,
, Protection of mouse photoreceptors by survival factors in retinal degenerations, Invest. Ophthalmol. Vis. Sci, vol.39, issue.3, pp.592-602, 1998.
Interaction of the insulin receptor beta-subunit with phosphatidylinositol 3-kinase in bovine ROS, Invest. Ophthalmol. Vis. Sci, vol.42, issue.13, pp.3110-3117, 2001. ,
Characterisation of insulin signaling in rat retina in vivo and ex vivo, Am. J. Physiol. Endocrinol. Metab, vol.285, pp.763-774, 2003. ,
Cell death in Retinitis pigmentosa: Gap junctions and the 'Bystander Effect, Exp. Eye Res, vol.74, pp.327-336, 2002. ,
Secretion of thioredoxin by normal and neoplastic cells through a leaderless secretory pathway, J. Biol. Chem, vol.267, pp.24161-24165, 1992. ,
Mammalian thioredoxin is a direct inhibitor of apoptosis signaling-regulating kinase [ASK] 1, EMBO J, vol.17, pp.2596-2606, 1998. ,
Intraocular gene delivery of ciliary neurotrophic factor results in significant loss of retinal function in normal mice and in the Prph2Rd2/Rd2 model of retinal degeneration, Gene Ther, vol.10, issue.6, pp.523-530, 2003. ,
Adenoassociated viruses containing bFGF or BDNF are neuroprotective against excitotoxicity, Curr. Eye Res, vol.29, issue.6, pp.379-86, 2004. ,
Ciliary neurotrophic factor, J. Neurobiol, vol.25, pp.1436-1453, 1994. ,
Ciliary Neurotrophic factor (CNTF) for human retinal degeneration: Phase 1 trial for CNTF delivered by encapsulated cell intraocular implants, Proc. Natl. Acad. Sci. USA, vol.10, pp.3896-3901, 2006. ,
Long-term doxycycline-regulated transgene expression in the retina of nonhuman primates following subretinal injection of recombinant AAV vectors, Mol. Ther, vol.13, issue.5, pp.967-75, 2006. ,
URL : https://hal.archives-ouvertes.fr/hal-02664856
A diffusible factor from normal cells promotes rod photoreceptor survival in an in vitro model of retinitis pigmentosa, J. Neurobiol, vol.39, pp.475-90, 1999. ,
Morphological and functional abnormalities in the inner retina of the rd1 mouse, J. Neuroscience, vol.22, issue.13, pp.5492-5504, 2002. ,
Redox regulation of cell signaling by selenocysteine in mammalian thioredoxin reductases, J. Biol. Chem, vol.274, pp.24522-24530, 1999. ,
Rescue from photoreceptor degeneration in the rd1 mouse by human immunodeficiency virus vector-mediated gene transfer, J. Virol, vol.73, issue.9, pp.7812-7818, 1999. ,
Sulforaphane induces thioredoxin through the antioxidant-responsive element and attenuates retinal light damage in Mice IOVS, vol.46, pp.979-987 ,
Encapsulated cell-based delivery of CNTF reduces photoreceptor degeneration in animal models of retinitis pigmentosa, Invest. Ophthalmol. Vis. Sci, issue.10, pp.3292-3300, 2002. ,
Intravitreous transplantation of encapsulated fibroblasts secreting the human fibroblast growth factor 2 delays photoreceptor cell degeneration in Royal College of Surgeons rats, Proc. Natl. Acad. Sci. USA, vol.96, issue.6, pp.3126-3157, 1999. ,
Topographical regulation of cone and rod opsin genes: parallel position dependent levels of transcription, Dev. Brain Res, vol.89, pp.146-149, 1995. ,
Isolation and characterization of a cDNA encoding the alpha' subunit of human cone cGMPphosphodiesterase, Gene, vol.166, pp.205-216, 1995. ,
Control of cell survival by IGFsignaling pathways, Growth Horm. IGF. Res, vol.12, pp.193-197, 2002. ,
Insulin signaling in health and disease, Science, vol.302, pp.1710-1711, 2003. ,
Fibroblast growth factor-2 decreases hyperoxia-induced photoreceptor cell death in mice, Am. J. Pathol, vol.159, pp.1113-1120, 2001. ,
Virus-mediated transduction of murine retina with adeno-associated virus: effects of viral capsid and genome size, J. Virol, vol.76, issue.15, pp.7651-60, 2002. ,
Insulin receptor substrate 2 is essential for maturation and survival of photoreceptor cells, J. Neurosci, vol.25, issue.5, pp.1240-1248, 2005. ,
Neurotrophic rescue of photoreceptors: are Muller cells the mediators of survival?, Neuron, vol.26, issue.2, pp.285-291, 2000. ,
Organ-specific gene expression in the rhesus monkey eye following intravenous non-viral gene transfer, Mol. Vis, vol.3, pp.465-72, 2003. ,