Skip to Main content Skip to Navigation
Journal articles

Diversity of Tumor-Infiltrating, γδ T-Cell Abundance in Solid Cancers

Abstract : γδ T-cells contribute to the immune response against many tumor types through their direct cytolytic functions and their capacity to recruit and regulate the biological functions of other immune cells. As potent effectors of the anti-tumor immune response, they are considered an attractive therapeutic target for immunotherapies, but their presence and abundance in the tumor microenvironment are not routinely assessed in patients with cancer. Here, we validated an antibody for immunohistochemistry analysis that specifically detects all γδ T-cell subpopulations in healthy tissues and in the microenvironment of different cancer types. Tissue microarray analysis of breast, colon, ovarian, and pancreatic tumors showed that γδ T-cell density varies among cancer types. Moreover, the abundance of γδ tumor-infiltrating lymphocytes was variably associated with the outcome depending on the cancer type, suggesting that γδ T-cell recruitment is influenced by the context. These findings also suggest that γδ T-cell detection and analysis might represent a new and interesting diagnostic or prognostic marker.
Document type :
Journal articles
Complete list of metadata

Cited literature [58 references]  Display  Hide  Download
Contributor : Virginie LAFONT Connect in order to contact the contributor
Submitted on : Monday, July 6, 2020 - 5:19:17 PM
Last modification on : Friday, August 5, 2022 - 10:56:30 AM
Long-term archiving on: : Monday, September 28, 2020 - 4:35:37 PM


Publication funded by an institution



Ghita Chabab, Florence Boissière-Michot, Caroline Mollevi, Jeanne Ramos, Evelyne Lopez-Crapez, et al.. Diversity of Tumor-Infiltrating, γδ T-Cell Abundance in Solid Cancers. Cells, MDPI, 2020, 9 (6), pp.E1537. ⟨10.3390/cells9061537⟩. ⟨inserm-02891037⟩



Record views


Files downloads