Clonal hematopoiesis is associated with adverse outcomes in multiple myeloma patients undergoing transplant - Archive ouverte HAL Access content directly
Journal Articles Nature Communications Year : 2020

Clonal hematopoiesis is associated with adverse outcomes in multiple myeloma patients undergoing transplant

(1, 2, 3) , (1, 2) , (1) , (1, 3) , (3) , (1) , (1, 4, 5) , (1, 6) , (1) , (1) , (1, 2, 3) , (1, 2, 3) , (1, 2, 3) , (1) , (1) , (7) , (1) , (1) , (1) , (1) , (1) , (8) , (1) , (9) , (9) , (1) , (1) , (1) , (1) , (1) , (1) , (1) , (1, 2, 3) , (1) , (1, 10) , (3, 7) , (1) , (1, 2, 3)
1
2
3
4
5
6
7
8
9
10
Nikhil C Munshi
  • Function : Author
  • PersonId : 909808

Abstract

Multiple myeloma (MM) is a plasma-cell neoplasm that is treated with high-dose chemotherapy, autologous stem cell transplant (ASCT) and long-term immunomodulatory drug (IMiD) maintenance. The presence of somatic mutations in the peripheral blood is termed clonal hematopoiesis of indeterminate potential (CHIP) and is associated with adverse outcomes. Targeted sequencing of the stem cell product from 629 MM patients treated by ASCT at the Dana-Farber Cancer Institute (2003-2011) detects CHIP in 136/629 patients (21.6%). The most commonly mutated genes are DNMT3A, TET2, TP53, ASXL1 and PPM1D. Twenty-one from fifty-six patients (3.3%) receiving first-line IMiD maintenance develop a therapy-related myeloid neoplasm (TMN). However, regardless of CHIP status, the use of IMiD maintenance associates with improved PFS and OS. In those not receiving IMiD maintenance, CHIP is associated with decreased overall survival (OS) (HR:1.34, p = 0.02) and progression free survival (PFS) (HR:1.45, p < 0.001) due to an increase in MM progression.
Fichier principal
Vignette du fichier
s41467-020-16805-5.pdf (1.04 Mo) Télécharger le fichier
Origin : Publication funded by an institution
Loading...

Dates and versions

inserm-02880831 , version 1 (25-06-2020)

Identifiers

Cite

Tarek H Mouhieddine, Adam S Sperling, Robert Redd, Jihye Park, Matthew Leventhal, et al.. Clonal hematopoiesis is associated with adverse outcomes in multiple myeloma patients undergoing transplant. Nature Communications, 2020, 11 (1), pp.2996. ⟨10.1038/s41467-020-16805-5⟩. ⟨inserm-02880831⟩

Collections

INSERM UNIV-LILLE
66 View
83 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More