Coupling of melanocyte signaling and mechanics by caveolae is required for human skin pigmentation - Archive ouverte HAL Access content directly
Journal Articles Nature Communications Year : 2020

Coupling of melanocyte signaling and mechanics by caveolae is required for human skin pigmentation

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Anne-Sophie Macé
  • Function : Author
  • PersonId : 958326

Abstract

Tissue homeostasis requires regulation of cell-cell communication, which relies on signaling molecules and cell contacts. In skin epidermis, keratinocytes secrete factors transduced by melanocytes into signaling cues promoting their pigmentation and dendrite outgrowth, while melanocytes transfer melanin pigments to keratinocytes to convey skin photoprotection. How epidermal cells integrate these functions remains poorly characterized. Here, we show that caveolae are asymmetrically distributed in melanocytes and particularly abundant at the melanocyte-keratinocyte interface in epidermis. Caveolae in melanocytes are modulated by ultraviolet radiations and keratinocytes-released factors, like miRNAs. Preventing caveolae formation in melanocytes increases melanin pigment synthesis through upregulation of cAMP signaling and decreases cell protrusions, cell-cell contacts, pigment transfer and epidermis pigmentation. Altogether, we identify that caveolae serve as molecular hubs that couple signaling outputs from keratinocytes to mechanical plasticity of pigment cells. The coordination of intercellular communication and contacts by caveolae is thus crucial to skin pigmentation and tissue homeostasis.
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Dates and versions

inserm-02877916 , version 1 (22-06-2020)

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Lia Domingues, Ilse Hurbain, Floriane Gilles-Marsens, Julia Sirés-Campos, Nathalie André, et al.. Coupling of melanocyte signaling and mechanics by caveolae is required for human skin pigmentation. Nature Communications, 2020, 11 (1), pp.2988. ⟨10.1038/s41467-020-16738-z⟩. ⟨inserm-02877916⟩
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