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A Role for CD154, the CD40 Ligand, in Granulomatous Inflammation

Abstract : Granulomatous inflammation is a distinctive form of chronic inflammation in which predominant cells include macrophages, epithelioid cells, and multinucleated giant cells. Mechanisms regulating granulomatous inflammation remain ill-understood. CD154, the ligand of CD40, is a key mediator of inflammation. CD154 confers a proinflammatory phenotype to macrophages and controls several macrophagic functions. Here, we studied the contribution of CD154 in a mouse model of toxic liver injury with carbon tetrachloride and a model of absorbable suture graft. In both models, granulomas are triggered in response to endogenous persistent liver calcified necrotic lesions or by grafted sutures. CD154-deficient mice showed delayed clearance of carbon tetrachloride-induced liver calcified necrotic lesions and impaired progression of suture-induced granuloma. In vitro, CD154 stimulated phagocytosis of opsonized erythrocytes by macrophages, suggesting a potential mechanism for the altered granulomatous inflammation in CD154KO mice. These results suggest that CD154 may contribute to the natural history of granulomatous inflammation.
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Contributor : Olivier Chassande Connect in order to contact the contributor
Submitted on : Tuesday, June 16, 2020 - 6:14:41 PM
Last modification on : Saturday, March 26, 2022 - 4:23:18 AM

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Julien Villeneuve, Alexis Desmoulière, Antoine Dewitte, Nelly Bordeau, Pierre Costet, et al.. A Role for CD154, the CD40 Ligand, in Granulomatous Inflammation. Mediators of Inflammation, Hindawi Publishing Corporation, 2017, 2017, pp.2982879. ⟨10.1155/2017/2982879⟩. ⟨inserm-02870606⟩



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