History of vaccination, Proc. Natl. Acad. Sci. USA, vol.111, pp.12283-12287, 2014. ,
Novel viral vectors in infectious diseases, Immunology, vol.153, pp.1-9, 2018. ,
DNA vaccines: how much have we accomplished in the last 25 years?, J. Vaccines Vaccin, vol.6, p.283, 2015. ,
Immunization with plasmid DNA encoding for the measles virus hemagglutinin and nucleoprotein leads to humoral and cell-mediated immunity, Virology, vol.225, pp.293-299, 1996. ,
Genetic immunization is a simple method for eliciting an immune response, Nature, vol.356, pp.152-154, 1992. ,
Heterologous protection against influenza by injection of DNA encoding a viral protein, Science, vol.259, pp.1745-1749, 1993. ,
DNA vaccination: antigen presentation and the induction of immunity, J. Leukoc. Biol, vol.68, pp.793-806, 2000. ,
DNA vaccines for HFRS: laboratory and clinical studies, Virus Res, vol.187, pp.91-96, 2014. ,
A multiagent filovirus DNA vaccine delivered by intramuscular electroporation completely protects mice from ebola and Marburg virus challenge, Hum. Vaccin. Immunother, vol.8, pp.1703-1706, 2012. ,
Codon-optimized filovirus DNA vaccines delivered by intramuscular electroporation protect cynomolgus macaques from lethal Ebola and Marburg virus challenges, Hum. Vaccin. Immunother, vol.11, pp.1991-2004, 2015. ,
Comparative immunogenicity in rhesus monkeys of DNA plasmid, recombinant vaccinia virus, and replication-defective adenovirus vectors expressing a human immunodeficiency virus type 1 gag gene, J. Virol, vol.77, pp.6305-6313, 2003. ,
DNA vaccines: protective immunizations by parenteral, mucosal, and gene-gun inoculations, Proc. Natl. Acad. Sci. USA, vol.90, pp.11478-11482, 1993. ,
Selected approaches for increasing HIV DNA vaccine immunogenicity in vivo, Curr. Opin. Virol, vol.1, pp.233-240, 2011. ,
A Phase 1 clinical trial of a DNA vaccine for Venezuelan equine encephalitis delivered by intramuscular or intradermal electroporation, Vaccine, vol.34, pp.3607-3612, 2016. ,
A Phase 1 clinical trial of Hantaan virus and Puumala virus M-segment DNA vaccines for haemorrhagic fever with renal syndrome delivered by intramuscular electroporation, Clin. Microbiol. Infect, vol.20, pp.110-117, 2014. ,
Indicators of therapeutic effect in FIT-06, a Phase II trial of a DNA vaccine, GTU(Ò)-Multi-HIVB, in untreated HIV-1 infected subjects, Vaccine, vol.30, pp.4046-4054, 2012. ,
Relative contributions of codon usage, promoter efficiency and leader sequence to the antigen expression and immunogenicity of HIV-1 Env DNA vaccine, Vaccine, vol.24, pp.4531-4540, 2006. ,
Gene-based vaccines: recent technical and clinical advances, Trends Mol. Med, vol.12, pp.216-222, 2006. ,
DNA vaccines: recent developments and future possibilities, Hum. Gene Ther, vol.17, pp.1051-1061, 2006. ,
A DNA HIV-1 vaccine based on a fusion gene expressing non-structural and structural genes of consensus sequence of the A-C subtypes and the ancestor sequence of the F-H subtypes. Preclinical and clinical studies, Microbes Infect, vol.7, pp.1405-1413, 2005. ,
The role of DNA structure and dynamics in the recognition of bovine papillomavirus E2 protein target sequences, J. Mol. Biol, vol.339, pp.785-796, 2004. ,
URL : https://hal.archives-ouvertes.fr/hal-00171688
Induction of human immunodeficiency virus type-1-specific immunity with a novel gene transport unit (GTU)-MultiHIV DNA vaccine, AIDS Res. Hum. Retroviruses, vol.22, pp.667-677, 2006. ,
Detection of integration of plasmid DNA into host genomic DNA following intramuscular injection and electroporation, Gene Ther, vol.11, pp.711-721, 2004. ,
Comparative analysis of immune responses induced by vaccination with SIV antigens by recombinant Ad5 vector or plasmid DNA in rhesus macaques, Mol. Ther, vol.18, pp.1568-1576, 2010. ,
Persistent immune responses induced by a human immunodeficiency virus DNA vaccine delivered in association with electroporation in the skin of nonhuman primates, Hum. Gene Ther, vol.20, pp.1291-1307, 2009. ,
Increased immune responses in rhesus macaques by DNA vaccination combined with electroporation, vol.26, pp.5223-5229, 2008. ,
Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2/3: a randomised, double-blind, placebo-controlled phase 2b trial, Lancet, vol.386, pp.2078-2088, 2015. ,
Clearance of persistent HPV infection and cervical lesion by therapeutic DNA vaccine in CIN3 patients, Nat. Commun, vol.5, p.5317, 2014. ,
Transcutaneous and intradermal vaccination, Hum. Vaccin, vol.7, pp.811-827, 2011. ,
Innate gene signature distinguishes humoral versus cytotoxic responses to influenza vaccination, J. Clin. Invest, vol.129, pp.1960-1971, 2019. ,
Human dendritic cells -stars in the skin, Eur. J. Immunol, vol.43, pp.3147-3155, 2013. ,
Delivery systems for intradermal vaccination, Curr. Top. Microbiol. Immunol, vol.351, pp.77-112, 2012. ,
Potent immunity to low doses of influenza vaccine by probabilistic guided microtargeted skin delivery in a mouse model, PLoS One, vol.5, p.10266, 2010. ,
Identification of skin immune cells in non-human primates, J. Immunol. Methods, vol.426, pp.42-49, 2015. ,
URL : https://hal.archives-ouvertes.fr/inserm-02437893
CD34-derived dendritic cells transfected ex vivo with HIV-Gag mRNA induce polyfunctional T-cell responses in nonhuman primates, Eur. J. Immunol, vol.42, pp.2019-2030, 2012. ,
Macrophage-and neutrophil-derived TNF-a instructs skin langerhans cells to prime antiviral immune responses, J. Immunol, vol.193, pp.2416-2426, 2014. ,
Langerhans cell antigen capture through tight junctions confers preemptive immunity in experimental staphylococcal scalded skin syndrome, J. Exp. Med, vol.208, pp.2607-2613, 2011. ,
Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells, Immunity, vol.39, pp.722-732, 2013. ,
Human tissues contain CD141hi cross-presenting dendritic cells with functional homology to mouse CD103+ nonlymphoid dendritic cells, Immunity, vol.37, pp.60-73, 2012. ,
Functional specializations of human epidermal Langerhans cells and CD14+ dermal dendritic cells, Immunity, vol.29, pp.497-510, 2008. ,
CD301b + dermal dendritic cells drive T helper 2 cellmediated immunity, Immunity, vol.39, pp.733-743, 2013. ,
Dermal dendritic cells" comprise two distinct populations: CD1+ dendritic cells and CD209+ macrophages, J. Invest. Dermatol, vol.128, pp.2225-2231, 2008. ,
Normal human dermis contains distinct populations of CD11c+BDCA-1+ dendritic cells and CD163+FXIIIA+ macrophages, J. Clin. Invest, vol.117, pp.2517-2525, 2007. ,
Differential rates of replacement of human dermal dendritic cells and macrophages during hematopoietic stem cell transplantation, J. Exp. Med, vol.206, pp.371-385, 2009. ,
Skin wound healing modulation by macrophages, Int. J. Clin. Exp. Pathol, vol.3, pp.643-653, 2010. ,
Monocyte and macrophage heterogeneity, Nat. Rev. Immunol, vol.5, pp.953-964, 2005. ,
Exploring the full spectrum of macrophage activation, Nat. Rev. Immunol, vol.10, pp.958-969, 2008. ,
Immunological mechanisms of vaccination, Nat. Immunol, vol.12, pp.509-517, 2011. ,
Human epidermal Langerhans cells maintain immune homeostasis in skin by activating skin resident regulatory T cells, Immunity, vol.36, pp.873-884, 2012. ,
Neutrophils transport antigen from the dermis to the bone marrow, initiating a source of memory CD8+ T cells, Immunity, vol.37, pp.917-929, 2012. ,
Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity, J. Exp. Med, vol.203, pp.413-424, 2006. ,
Electroporation as a vaccine delivery system and a natural adjuvant to intradermal administration of plasmid DNA in macaques, Sci Rep, vol.7, p.4122, 2017. ,
URL : https://hal.archives-ouvertes.fr/inserm-02437890
Electroporation-Mediated Intradermal Delivery of DNA Vaccines in Nonhuman Primates, pp.309-313, 2014. ,
Techniques for time-efficient isolation of human skin dendritic cell subsets and assessment of their antigen uptake capacity, J. Immunol. Methods, vol.348, pp.42-56, 2009. ,
Isolation of skin dendritic cells from mouse and man, Methods Mol. Biol, vol.595, pp.235-248, 2010. ,
Improving the efficiency of multidimensional scaling in the analysis of highdimensional data using singular value decomposition, Bioinformatics, vol.27, pp.1413-1421, 2011. ,
Quantitative Applications in the Social Sciences: Multidimensional scaling, 1978. ,
Resident and "inflammatory" dendritic cells in human skin, J. Invest. Dermatol, vol.129, pp.302-308, 2009. ,
Systematic validation of specific phenotypic markers for in vitro polarized human macrophages, J. Immunol. Methods, vol.375, pp.196-206, 2012. ,
Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status, J. Neuroinflammation, vol.10, p.35, 2013. ,
Identification of Aim2 as a sensor for DNA vaccines, J. Immunol, vol.194, pp.630-636, 2015. ,
Programming the magnitude and persistence of antibody responses with innate immunity, Nature, vol.470, pp.543-547, 2011. ,
Human adipose tissue macrophages are of an anti-inflammatory phenotype but capable of excessive proinflammatory mediator production, Int. J. Obes, vol.31, pp.1420-1428, 2007. ,
Macrophage activation switching: an asset for the resolution of inflammation, Clin. Exp. Immunol, vol.142, pp.481-489, 2005. ,
A subpopulation of CD163-positive macrophages is classically activated in psoriasis, J. Invest. Dermatol, vol.130, pp.2412-2422, 2010. ,
Origins and functional specialization of macrophages and of conventional and monocyte-derived dendritic cells in mouse skin, Immunity, vol.39, pp.925-938, 2013. ,
Minimal differentiation of classical monocytes as they survey steady-state tissues and transport antigen to lymph nodes, Immunity, vol.39, pp.599-610, 2013. ,
Stroma-derived interleukin-34 controls the development and maintenance of langerhans cells and the maintenance of microglia, Immunity, vol.37, pp.1050-1060, 2012. ,
Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis, Immunity, vol.38, pp.79-91, 2013. ,
Expression and function of the mannose receptor CD206 on epidermal dendritic cells in inflammatory skin diseases, J. Invest. Dermatol, vol.118, pp.327-334, 2002. ,
Human inflammatory dendritic epidermal cells express a functional histamine H4 receptor, J. Invest. Dermatol, vol.128, pp.1696-1703, 2008. ,
Harnessing dendritic cells in inflammatory skin diseases, Semin. Immunol, vol.23, pp.28-41, 2011. ,
Major differences in inflammatory dendritic cells and their products distinguish atopic dermatitis from psoriasis, J. Allergy Clin. Immunol, vol.119, pp.1210-1217, 2007. ,
Two distinct types of Langerhans cells populate the skin during steady state and inflammation, Immunity, vol.37, pp.905-916, 2012. ,
Langerhans cells renew in the skin throughout life under steady-state conditions, Nat. Immunol, vol.4, pp.1135-1141, 2002. ,
Fibered confocal fluorescence microscopy for the Noninvasive imaging of langerhans cells in macaques, Contrast Media Mol. Imaging, p.3127908, 2017. ,
Langerhans cells transport Leishmania major from the infected skin to the draining lymph node for presentation to antigen-specific T cells, Eur. J. Immunol, vol.23, pp.1595-1601, 1993. ,
Skin electroporation: effects on transgene expression, DNA persistence and local tissue environment, PLoS One, vol.4, p.7226, 2009. ,
Enhanced delivery of naked DNA to the skin by non-invasive in vivo electroporation, Biochim. Biophys. Acta, vol.1572, pp.1-9, 2002. ,
Electric pulses applied prior to intramuscular DNA vaccination greatly improve the vaccine immunogenicity, Vaccine, vol.25, pp.2064-2073, 2007. ,
Increased gene expression and inflammatory cell infiltration caused by electroporation are both important for improving the efficacy of DNA vaccines, J. Biotechnol, vol.110, pp.1-10, 2004. ,
Recruitment of antigen-presenting cells to the site of inoculation and augmentation of human immunodeficiency virus type 1 DNA vaccine immunogenicity by in vivo electroporation, J. Virol, vol.82, pp.5643-5649, 2008. ,
Efficient and regulated erythropoietin production by naked DNA injection and muscle electroporation, Proc. Natl. Acad. Sci. USA, vol.96, pp.6417-6422, 1999. ,
The transcription factor FOXM1 (Forkhead box M1): proliferation-specific expression, transcription factor function, target genes, mouse models, and normal biological roles, Adv. Cancer Res, vol.118, pp.97-398, 2013. ,
FOXM1, a typical proliferation-associated transcription factor, Biol. Chem, vol.388, pp.1257-1274, 2007. ,
p63 in skin development and ectodermal dysplasias, J. Invest. Dermatol, vol.130, pp.2352-2358, 2010. ,
A preliminary study of differentially expressed genes in expanded skin and normal skin: implications for adult skin regeneration, Arch. Dermatol. Res, vol.303, pp.125-133, 2011. ,
Dendritic-cell control of pathogen-driven T-cell polarization, Nat. Rev. Immunol, vol.3, pp.984-993, 2003. ,
Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo, J. Exp. Med, vol.194, pp.769-779, 2001. ,
Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells, J. Exp. Med, vol.192, pp.1213-1222, 2000. ,
The differential production of cytokines by human Langerhans cells and dermal CD14(+) DCs controls CTL priming, Blood, vol.119, pp.5742-5749, 2012. ,
IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cells, Proc. Natl. Acad. Sci. USA, vol.101, pp.1969-1974, 2004. ,
IL-15-induced human DC efficiently prime melanomaspecific naive CD8+ T cells to differentiate into CTL, Eur. J. Immunol, vol.37, pp.1678-1690, 2007. ,
Immunologic basis of vaccine vectors, Immunity, vol.33, pp.504-515, 2010. ,
TLR9 pathway is involved in adjuvant effects of plasmid DNA-based vaccines, Vaccine, vol.23, pp.1258-1264, 2005. ,
URL : https://hal.archives-ouvertes.fr/hal-02680528
TLR9 -/-and TLR9 +/+ mice display similar immune responses to a DNA vaccine, Immunology, vol.113, pp.114-120, 2004. ,
Vaccination with plasmid DNA activates dendritic cells via Toll-like receptor 9 (TLR9) but functions in TLR9-deficient mice, J. Immunol, vol.171, pp.5908-5912, 2003. ,
NF-kB activation during intradermal DNA vaccination is essential for eliciting tumor protective antigen-specific CTL responses, Hum. Vaccin. Immunother, vol.9, pp.2189-2195, 2013. ,
RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway, Cell, vol.138, pp.576-591, 2009. ,
AIM2 Co-immunization with VP1 is associated with increased memory CD8 T cells and mounts long lasting protection against coxsackievirus B3 challenge, Front. Cell. Infect. Microbiol, vol.7, p.247, 2017. ,