PPARδ-mediated mitochondrial rewiring of osteoblasts determines bone mass - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Scientific Reports Année : 2020

PPARδ-mediated mitochondrial rewiring of osteoblasts determines bone mass

Résumé

Bone turnover, which is determined by osteoclast-mediated bone resorption and osteoblast-mediated bone formation, represents a highly energy consuming process. The metabolic requirements of osteoblast differentiation and mineralization, both essential for regular bone formation, however, remain incompletely understood. Here we identify the nuclear receptor peroxisome proliferator-activated receptor (PPAR) δ as key regulator of osteoblast metabolism. Induction of PPARδ was essential for the metabolic adaption and increased rate in mitochondrial respiration necessary for the differentiation and mineralization of osteoblasts. Osteoblast-specific deletion of PPARδ in mice, in turn, resulted in an altered energy homeostasis of osteoblasts, impaired mineralization and reduced bone mass. These data show that PPARδ acts as key regulator of osteoblast metabolism and highlight the relevance of cellular metabolic rewiring during osteoblast-mediated bone formation and bone-turnover.
Fichier principal
Vignette du fichier
s41598-020-65305-5.pdf (2.96 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

inserm-02869506 , version 1 (16-06-2020)

Identifiants

Citer

Dorothea I H Müller, Cornelia Stoll, Katrin Palumbo-Zerr, Christina Böhm, Brenda Krishnacoumar, et al.. PPARδ-mediated mitochondrial rewiring of osteoblasts determines bone mass. Scientific Reports, 2020, 10 (1), pp.8428. ⟨10.1038/s41598-020-65305-5⟩. ⟨inserm-02869506⟩
393 Consultations
140 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More