Self-control of vitamin K 2 production captured in the crystal EDITORS' PICK HIGHLIGHT Downloaded from - Archive ouverte HAL Access content directly
Journal Articles Journal of Biological Chemistry Year : 2020

Self-control of vitamin K 2 production captured in the crystal EDITORS' PICK HIGHLIGHT Downloaded from

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Abstract

Menaquinone (MK) or vitamin K2 is an important metabolite that controls the redox/energy status of Mycobacterium tuberculosis Although the major steps of MK biosynthesis have been delineated, the regulatory mechanisms of this pathway have not been adequately explored. Bashiri et al. now demonstrate that MenD, catalyzing the first committed step of MK production, is allosterically inhibited by a downstream cytosolic metabolite in the MK biosynthesis pathway.
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inserm-02868898 , version 1 (15-06-2020)

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Blaise Mickaël, Laurent Kremer. Self-control of vitamin K 2 production captured in the crystal EDITORS' PICK HIGHLIGHT Downloaded from. Journal of Biological Chemistry, 2020, 295 (12), pp.3771-3772. ⟨10.1074/jbc.H120.013113⟩. ⟨inserm-02868898⟩
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