P. Puri, K. Daita, A. Joyce, F. Mirshahi, P. K. Santhekadur et al., , p.429

M. J. Contos, M. Idowu, and A. J. Sanyal, The presence and severity of nonalcoholic steatohepatitis 430 is associated with specific changes in circulating bile acids, Hepatology, vol.67, issue.2, p.29

V. Legry, S. Francque, J. T. Haas, A. Verrijken, S. Caron et al., , p.432

E. Vallez, L. Vonghia, E. Dirinck, A. Verhaegen, M. Kouach et al., , p.433

L. Gaal, A. Tailleux, R. Paumelle, and B. Staels, Bile Acid Alterations Are Associated With 434 Insulin Resistance, but Not With NASH, in Obese Subjects, J. Clin. Endocrinol. Metab, vol.435, issue.10, pp.3783-3794, 2017.

E. B. Tapper, K. Krajewski, M. Lai, T. Challies, R. Kane et al., Simple 437 non-invasive biomarkers of advanced fibrosis in the evaluation of non-alcoholic fatty liver 438 disease, Gastroenterol. Rep, vol.2, issue.4, p.31, 2014.

Z. Wang, M. Xu, Z. Hu, M. Hultström, and E. Lai, Sex-specific prevalence of fatty liver 440 disease and associated metabolic factors in Wuhan, south central China, Eur. J, p.441

, Gastroenterol. Hepatol, vol.26, issue.9, p.32, 2014.

M. Sarkar, M. Wellons, M. I. Cedars, L. Vanwagner, E. P. Gunderson et al., , p.443

L. Torchen, D. Siscovick, J. J. Carr, J. G. Terry, M. Rinella et al.,

, Testosterone Levels in Pre-Menopausal Women are Associated With Nonalcoholic Fatty 445 Liver Disease in Midlife, Am. J. Gastroenterol, vol.112, issue.5, p.33, 2017.

M. Sarkar, L. B. Vanwagner, J. G. Terry, J. J. Carr, M. Rinella et al., Lewis 447 CE, Terrault N. Sex Hormone-Binding Globulin Levels in Young Men Are Associated, p.448

, With Nonalcoholic Fatty Liver Disease in Midlife, Am. J. Gastroenterol, vol.114, issue.5, p.34, 2019.

S. Zhang, X. Zeng, M. Ren, X. Mao, and S. Qiao, 452 35. Lynch CJ, Adams SH. Branched-chain amino acids in metabolic signalling and 453 insulin resistance, J. Anim. Sci. Biotechnol, vol.8, issue.1, p.36, 2014.

S. H. Um, D. 'alessio, D. Thomas, and G. , Nutrient overload, insulin resistance, and 455 ribosomal protein S6 kinase 1, S6K1, Cell Metab, vol.3, issue.6, p.37, 2006.

M. Krebs, B. Brunmair, A. Brehm, M. Artwohl, J. Szendroedi et al., , p.457

C. Fürnsinn, M. Promintzer, C. Anderwald, M. Bischof, and M. Roden, The Mammalian Target 458 of Rapamycin Pathway Regulates Nutrient-Sensitive Glucose Uptake in Man, Diabetes, vol.459, issue.6, pp.1600-1607, 2007.

R. L. Wolfson, L. Chantranupong, R. A. Saxton, K. Shen, S. M. Scaria et al., , p.461

D. M. Sabatini, Sestrin2 is a leucine sensor for the mTORC1 pathway, Science, vol.462, issue.6268, pp.43-48, 2016.

F. Zhang, S. Zhao, W. Yan, Y. Xia, X. Chen et al., , p.464

F. Yan, H. Zhao, K. Lian, Y. Lee, L. Zhang et al., , p.465

, Acids Cause Liver Injury in Obese/Diabetic Mice by Promoting Adipocyte Lipolysis and 466 Inhibiting Hepatic Autophagy, EBioMedicine, vol.13, p.40, 2016.

G. Marchesini, G. Bianchi, M. Merli, P. Amodio, and C. Panella, , p.468

F. Fanelli and R. Abbiati, Nutritional supplementation with branched-chain amino acids in 469 advanced cirrhosis: a double-blind, randomized trial, Gastroenterology, vol.124, issue.7, p.41, 2003.

Y. Muto, S. Sato, A. Watanabe, H. Moriwaki, K. Suzuki et al., , p.472

T. Nakamura, K. Higuchi, S. Nishiguchi, and H. Kumada, Effects of Oral Branched-Chain 473

, Amino Acid Granules on Event-Free Survival in Patients With Liver Cirrhosis, Clin, vol.474

, Gastroenterol. Hepatol, vol.3, issue.7, p.42, 2005.

H. Fukui, H. Saito, Y. Ueno, H. Uto, K. Obara et al., , p.476

S. Nagoshi, M. Segawa, H. Tsubouchi, H. Moriwaki, A. Kato et al., , p.477

T. Murawaki, K. Sugano, M. Watanabe, and T. Shimosegawa, , p.478