H. I. Bishop, D. Guan, E. Bocksteins, L. K. Parajuli, K. D. Murray et al., , p.447

R. C. Foehring and J. S. Trimmer, Distinct cell-and layer-specific expression patterns and 448 independent regulation of Kv2 channel subtypes in cortical pyramidal neurons, J 449 Neurosci, vol.35, pp.14922-14942, 2015.

R. Boehringer, D. Polygalov, A. Huang, S. J. Middleton, V. Robert et al., , p.451

V. Chevaleyre and T. J. Mchugh, Chronic loss of CA2 transmission leads to 452 hippocampal hyperexcitability, Neuron, vol.94, pp.642-655, 2017.

A. C. Bragdon, D. M. Taylor, and W. A. Wilson, Potassium-induced epileptiform activity in area CA3 454 varies markedly along the septotemporal axis of the rat hippocampus, Brain Res, vol.455, pp.169-173, 1986.

V. Chevaleyre and S. A. Siegelbaum, Strong CA2 pyramidal neuron synapses define a powerful 457 disynaptic cortico-hippocampal loop, Neuron, vol.66, pp.560-572, 2010.

J. Du, L. L. Haak, E. Phillips-tansey, J. T. Russell, and C. J. Mcbain, Frequency-dependent 459 regulation of rat hippocampal somato-dendritic excitability by the K+ channel subunit 460 Kv2.1, J Physiol, vol.522, pp.19-31, 2000.

D. Guan, T. Tkatch, D. J. Surmeier, W. E. Armstrong, and R. C. Foehring, Kv2 subunits underlie 462 slowly inactivating potassium current in rat neocortical pyramidal neurons, J Physiol, vol.463, pp.941-960, 2007.

F. L. Hitti and S. A. Siegelbaum, The hippocampal CA2 region is essential for social memory, Nature, vol.465, pp.88-92, 2014.

P. M. Hwang, M. Fotuhi, D. S. Bredt, A. M. Cunningham, and S. H. Snyder, Contrasting 467 immunohistochemical localizations in rat brain of two novel K+ channels of the Shab 468 subfamily, J Neurosci, vol.13, pp.1569-1576, 1993.

K. Kay, M. Sosa, J. E. Chung, M. P. Karlsson, M. C. Larkin et al., A hippocampal network 470 for spatial coding during immobility and sleep, Nature, vol.531, pp.185-190, 2016.

A. N. King, C. F. Manning, and J. S. Trimmer, A unique ion channel clustering domain on the axon 472 initial segment of mammalian neurons, J Comp Neurol, vol.522, pp.2594-2608, 2014.

T. Kirizs, K. Kerti-szigeti, A. Lorincz, and Z. Nusser, Distinct axo-somato-dendritic distributions 474 of three potassium channels in CA1 hippocampal pyramidal cells, Eur J Neurosci, vol.475, pp.1771-1783, 2014.

K. Kohara, M. Pignatelli, A. J. Rivest, H. Y. Jung, T. Kitamura et al., , p.477

Y. Obata, I. R. Wickersham, and S. Tonegawa, Cell type-specific genetic and optogenetic 478 tools reveal hippocampal CA2 circuits, Nat Neurosci, vol.17, pp.269-279, 2014.

J. Kuja-panula, M. Kiiltomaki, T. Yamashiro, A. Rouhiainen, and H. Rauvala, AMIGO, a 480 transmembrane protein implicated in axon tract development, defines a novel protein 481 family with leucine-rich repeats, J Cell Biol, vol.160, pp.963-973, 2003.

S. E. Lee, S. B. Simons, S. A. Heldt, M. Zhao, J. P. Schroeder et al., , p.483

C. K. Yates, Y. Feng, Y. Smith, J. D. Sweatt, D. Weinshenker et al., Hepler 484 JR (2010) RGS14 is a natural suppressor of both synaptic plasticity in CA2 neurons and 485 hippocampal-based learning and memory, Proc Natl Acad Sci U S A, vol.107, pp.16994-16998

E. S. Lein, X. Zhao, and F. H. Gage, Defining a molecular atlas of the hippocampus using DNA 487 microarrays and high-throughput in situ hybridization, J Neurosci, vol.24, pp.3879-3889, 2004.

E. S. Lein, E. M. Callaway, T. D. Albright, and F. H. Gage, Redefining the boundaries of the 489 hippocampal CA2 subfield in the mouse using gene expression and 3-dimensional 490 reconstruction, J Comp Neurol, vol.485, pp.1-10, 2005.

X. G. Li, P. Somogyi, A. Ylinen, and G. Buzsaki, The hippocampal CA3 network: an in vivo 492 intracellular labeling study, J Comp Neurol, vol.339, pp.181-208, 1994.

M. Linkert, C. T. Rueden, C. Allan, J. M. Burel, W. Moore et al.,

D. Macdonald, A. Tarkowska, C. Sticco, E. Hill, M. Rossner et al., Metadata matters: access to image data in the real world, J Cell Biol, vol.495, pp.777-782, 2010.

P. W. Liu and B. P. Bean, Kv2 channel regulation of action potential repolarization and firing 497 patterns in superior cervical ganglion neurons and hippocampal CA1 pyramidal neurons, J Neurosci, vol.498, pp.4991-5002, 2014.

L. De-nó and R. , Studies on the structure of the cerebral cortex. II. Continuation of the 500 study of the ammonic system, J Psychol Neurol, vol.46, pp.113-177, 1934.

J. C. Magee and D. Johnston, A synaptically controlled, associative signal for Hebbian plasticity 502 in hippocampal neurons, Science, vol.275, pp.209-213, 1997.

M. Maletic-savatic, N. J. Lenn, and J. S. Trimmer, Differential spatiotemporal expression of K+ 504 channel polypeptides in rat hippocampal neurons developing in situ and in vitro, J 505 Neurosci, vol.15, pp.3840-3851, 1995.

D. Mandikian, E. Bocksteins, L. K. Parajuli, H. I. Bishop, O. Cerda et al., , p.507, 2014.

, Cell type-specific spatial and functional coupling between mammalian brain Kv2.1 K(+) 508 channels and ryanodine receptors, J Comp Neurol, vol.522, pp.3555-3574

E. A. Mankin, G. W. Diehl, F. T. Sparks, S. Leutgeb, and J. K. Leutgeb, Hippocampal CA2 activity 510 patterns change over time to a larger extent than between spatial contexts, Neuron, vol.511, pp.190-201, 2015.

C. F. Manning, A. M. Bundros, and J. S. Trimmer, Benefits and pitfalls of secondary antibodies: why 513 choosing the right secondary is of primary importance, PLoS One, vol.7, p.38313, 2012.

H. Murakoshi and J. S. Trimmer, Identification of the Kv2.1 K+ channel as a major component 515 of the delayed rectifier K+ current in rat hippocampal neurons, J Neurosci, vol.19, pp.1728-1735, 1999.

N. H. Nakamura, V. Flasbeck, N. Maingret, T. Kitsukawa, and M. M. Sauvage, Proximodistal 517 segregation of nonspatial information in CA3: preferential recruitment of a proximal CA3-518 distal CA1 network in nonspatial recognition memory, J Neurosci, vol.33, pp.11506-11514, 2013.

K. J. Rhodes, K. I. Carroll, M. A. Sung, L. C. Doliveira, M. M. Monaghan et al., , p.520

L. Buchwalder, M. Menegola, J. Cao, W. F. An, and J. S. Trimmer, KChIPs and Kv4 alpha 521 subunits as integral components of A-type potassium channels in mammalian brain, J 522 Neurosci, vol.24, pp.7903-7915, 2004.

P. D. Sarmiere, C. M. Weigle, and M. M. Tamkun, The Kv2.1 K+ channel targets to the axon initial 524 segment of hippocampal and cortical neurons in culture and in situ, BMC Neurosci, vol.9, p.112, 2008.

S. A. Schnell, W. A. Staines, and M. W. Wessendorf, Reduction of lipofuscin-like autofluorescence 526 in fluorescently labeled tissue, J Histochem Cytochem, vol.47, pp.719-730, 1999.

S. B. Simons, Y. Escobedo, R. Yasuda, and S. M. Dudek, Regional differences in hippocampal 528 calcium handling provide a cellular mechanism for limiting plasticity, Proc Natl Acad Sci, vol.529, pp.14080-14084, 2009.

D. J. Speca, G. Ogata, D. Mandikian, H. I. Bishop, S. W. Wiler et al., , p.531

K. L. Campi, M. S. Golub, J. M. Nerbonne, J. W. Hell, B. C. Trainor et al., , p.532

J. S. Trimmer, Deletion of the Kv2.1 delayed rectifier potassium channel leads to 533 neuronal and behavioral hyperexcitability, Genes Brain Behav, vol.13, pp.394-408, 2014.

K. V. Srinivas, E. W. Buss, Q. Sun, B. Santoro, H. Takahashi et al., , p.535, 2017.

, The dendrites of CA2 and CA1 pyramidal neurons differentially regulate information flow 536 in the cortico-hippocampal circuit, J Neurosci, vol.37, pp.3276-3293

E. L. Stevenson and H. K. Caldwell, Lesions to the CA2 region of the hippocampus impair social 538 memory in mice, Eur J Neurosci, vol.40, pp.3294-3301, 2014.

Q. Sun, K. V. Srinivas, A. Sotayo, and S. A. Siegelbaum, Dendritic Na+ spikes enable cortical input 540 to drive action potential output from hippocampal CA2 pyramidal neurons, vol.3, 2014.

E. M. Talley, G. Solorzano, Q. Lei, D. Kim, and D. A. Bayliss, CNS distribution of members of the 542 two-pore-domain (KCNK) potassium channel family, J Neurosci, vol.21, pp.7491-7505, 2001.

I. Thiffault, D. J. Speca, D. C. Austin, M. M. Cobb, K. S. Eum et al., , p.544

S. Soden, S. F. Kingsmore, J. S. Trimmer, C. J. Saunders, and J. T. Sack, A novel epileptic 545 encephalopathy mutation in KCNB1 disrupts Kv2.1 ion selectivity, expression, and 546 localization, J Gen Physiol, vol.146, pp.399-410, 2015.

C. L. Thompson, S. D. Pathak, A. Jeromin, L. L. Ng, C. R. Macpherson et al., , p.548

S. M. Sunkin, A. Bernard, R. B. Puchalski, F. H. Gage, A. R. Jones et al., , p.549

E. S. Lein, Genomic anatomy of the hippocampus, Neuron, vol.60, pp.1010-1021, 2008.

A. Torkamani, K. Bersell, B. S. Jorge, R. L. Bjork, J. Friedman et al., , p.551

S. Naidu, C. G. Vanoye, A. L. George, J. Kearney, and J. A. , De novo KCNB1 mutations in 552 epileptic encephalopathy, Ann Neurol, vol.76, pp.529-540, 2014.

J. S. Trimmer, Immunological identification and characterization of a delayed rectifier K+ 554 channel polypeptide in rat brain, Proc Natl Acad Sci U S A, vol.88, pp.10764-10768, 1991.

E. C. Vega-saenz-de-miera, Modification of Kv2.1 K+ currents by the silent Kv10 subunits, 2004.

, Brain Res Mol Brain Res, vol.123, pp.91-103

M. Zhao, Y. S. Choi, K. Obrietan, and S. M. Dudek, Synaptic plasticity (and the lack thereof) in 558 hippocampal CA2 neurons, J Neurosci, vol.27, pp.12025-12032, 2007.