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Age-Dependent Specific Changes in Area CA2 of the Hippocampus and Social Memory Deficit in a Mouse Model of the 22q11.2 Deletion Syndrome

Abstract : Several neuropsychiatric disorders are associated with cognitive and social dysfunction. Postmortem studies of patients with schizophrenia have revealed specific changes in area CA2, a long-overlooked region of the hippocampus recently found to be critical for social memory formation. To examine how area CA2 is altered in psychiatric illness, we used the Df(16)A(+/-) mouse model of the 22q11.2 microdeletion, a genetic risk factor for developing several neuropsychiatric disorders, including schizophrenia. We report several age-dependent CA2 alterations: a decrease in the density of parvalbumin-expressing interneurons, a reduction in the amount of feedforward inhibition, and a change in CA2 pyramidal-neuron intrinsic properties. Furthermore, we found that area CA2 is less plastic in Df(16)A(+/-) mice, making it nearly impossible to evoke action potential firing in CA2 pyramidal neurons. Finally, we show that Df(16)A(+/-) mice display impaired social cognition, providing a potential mechanism and a neural substrate for this impairment in psychiatric disorders.
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https://www.hal.inserm.fr/inserm-02768786
Contributor : Rebecca Ann Piskorowski <>
Submitted on : Thursday, June 4, 2020 - 10:45:23 AM
Last modification on : Saturday, June 6, 2020 - 4:20:37 AM

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Rebecca Piskorowski, Kaoutsar Nasrallah, Anastasia Diamantopoulou, Jun Mukai, Sami Hassan, et al.. Age-Dependent Specific Changes in Area CA2 of the Hippocampus and Social Memory Deficit in a Mouse Model of the 22q11.2 Deletion Syndrome. Neuron, Elsevier, 2016, 89 (1), pp.163-176. ⟨10.1016/j.neuron.2015.11.036⟩. ⟨inserm-02768786⟩

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