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Is there a specific memory signature associated with Aβ-PET positivity in patients with amnestic mild cognitive impairment?

Abstract : Amnestic mild cognitive impairment (aMCI) is a clinical entity with various potential etiologies including but not limited to Alzheimer's disease. We examined whether a positive ([18F]Florbetapir) beta amyloid positron emission tomography scan, supporting underlying Alzheimer's disease pathophysiology, was associated with specific memory deficits in 48 patients with aMCI (33 beta amyloid positive, 15 beta amyloid negative). Memory was evaluated using an autobiographical fluency task and a word-list learning task with 2 different encoding types (shallow/incidental versus deep/intentional). Compared with 40 beta amyloidenegative controls, both aMCI subgroups demonstrated severe deficits in the global memory score and in most subscores of both tasks. Finer-grained analyses of memory tests showed subtle association with beta amyloid status, revealing a stronger impairment of the primacy effect in beta amyloidepositive patients. Structural magnetic resonance imaging showed that both aMCI subgroups exhibited comparable atrophy patterns, with similar degrees of medial temporal volume loss compared with controls. Specifically assessing the primacy effect might complement global memory scores in identifying beta amyloidepositive patients with aMCI.
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https://www.hal.inserm.fr/inserm-02747407
Contributor : Gaëlle Chetelat <>
Submitted on : Wednesday, June 3, 2020 - 11:52:19 AM
Last modification on : Friday, September 18, 2020 - 2:35:05 PM

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Clémence Tomadesso, Julie Gonneaud, Stéphanie Egret, Audrey Perrotin, Alice Pélerin, et al.. Is there a specific memory signature associated with Aβ-PET positivity in patients with amnestic mild cognitive impairment?. Neurobiology of Aging, Elsevier, 2019, 77, pp.94-103. ⟨10.1016/j.neurobiolaging.2019.01.017⟩. ⟨inserm-02747407⟩

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