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Progress update from the hippocampal subfields group

Rosanna K Olsen 1, 2 Valerie A Carr 3 Ana M Daugherty 4 Renaud La Joie 5 Robert S.C. Amaral 6 Katrin Amunts 7 Jean C Augustinack 8 Arnold Bakker 9 Andrew R Bender 10 David Berron 11 Marina Boccardi 12 Martina Bocchetta 13 Alison C Burggren 14 M. Mallar Mallar Chakravarty 15 Gaël Chételat 16, 17, 18 Robin Flores 16, 17 Jordan Dekraker 19 Song‐lin Ding 20 Mirjam I Geerlings 21 yushan Huang 22 Ricardo Insausti 23 Elliott G Johnson 24 Prabesh Kanel 25 Olga Kedo 26 Kristen M Kennedy 27 Attila Keresztes 28 Joshua K Lee 29 Ulman M Lindenberger 30 Susanne Mueller 31 Elizabeth M Mulligan 32 Noa Ofen 4, 33 Daniela J Palombo 34 Lorenzo Pasquini 31 John Pluta 35 Naftali Raz 4 Karen M Rodrigue 27 Margaret L Schlichting 2 yee Lee Shing 28, 36 Craig E.L. Stark 37 Trevor A Steve 22 Nanthia A Suthana 38 Lei Wang 39 Markus Werkle‐bergner 28 Paul A. yushkevich 40 Qijing yu 4 Laura E.M. Wisse 35 
Abstract : Introduction: Heterogeneity of segmentation protocols for medial temporal lobe regions and hippo-campal subfields on in vivo magnetic resonance imaging hinders the ability to integrate findings across studies. We aim to develop a harmonized protocol based on expert consensus and histological evidence. Methods: Our international working group, funded by the EU Joint Programme-Neurodegenerative Disease Research (JPND), is working toward the production of a reliable, validated, harmonized protocol for segmentation of medial temporal lobe regions. The working group uses a novel postmortem data set and online consensus procedures to ensure validity and facilitate adoption. Results: This progress report describes the initial results and milestones that we have achieved to date, including the development of a draft protocol and results from the initial reliability tests and consensus procedures. Discussion: A harmonized protocol will enable the standardization of segmentation methods across laboratories interested in medial temporal lobe research worldwide.
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Rosanna K Olsen, Valerie A Carr, Ana M Daugherty, Renaud La Joie, Robert S.C. Amaral, et al.. Progress update from the hippocampal subfields group. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Wiley, 2019, 11 (1), pp.439-449. ⟨10.1016/j.dadm.2019.04.001⟩. ⟨inserm-02747115⟩

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