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Journal Articles Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring Year : 2019

Progress update from the hippocampal subfields group

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Marina Boccardi

Abstract

Introduction: Heterogeneity of segmentation protocols for medial temporal lobe regions and hippo-campal subfields on in vivo magnetic resonance imaging hinders the ability to integrate findings across studies. We aim to develop a harmonized protocol based on expert consensus and histological evidence. Methods: Our international working group, funded by the EU Joint Programme-Neurodegenerative Disease Research (JPND), is working toward the production of a reliable, validated, harmonized protocol for segmentation of medial temporal lobe regions. The working group uses a novel postmortem data set and online consensus procedures to ensure validity and facilitate adoption. Results: This progress report describes the initial results and milestones that we have achieved to date, including the development of a draft protocol and results from the initial reliability tests and consensus procedures. Discussion: A harmonized protocol will enable the standardization of segmentation methods across laboratories interested in medial temporal lobe research worldwide.
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Dates and versions

inserm-02747115 , version 1 (03-06-2020)

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Rosanna K Olsen, Valerie A Carr, Ana M Daugherty, Renaud La Joie, Robert S.C. Amaral, et al.. Progress update from the hippocampal subfields group. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2019, 11 (1), pp.439-449. ⟨10.1016/j.dadm.2019.04.001⟩. ⟨inserm-02747115⟩
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