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Progress update from the hippocampal subfields group

Rosanna Olsen 1, 2 Valerie Carr 3 Ana Daugherty 4 Renaud La Joie 5 Robert S.C. Amaral 6 Katrin Amunts 7 Jean Augustinack 8 Arnold Bakker 9 Andrew Bender 10 David Berron 11 Marina Boccardi 12 Martina Bocchetta 13 Alison Burggren 14 M. Mallar Chakravarty 15 Gaël Chételat 16, 17, 18 Robin Flores 16, 17 Jordan Dekraker 19 Song‐lin Ding 20 Mirjam Geerlings 21 Yushan Huang 22 Ricardo Insausti 23 Elliott Johnson 24 Prabesh Kanel 25 Olga Kedo 26 Kristen Kennedy 27 Attila Keresztes 28 Joshua Lee 29 Ulman Lindenberger 30 Susanne Mueller 31 Elizabeth Mulligan 32 Noa Ofen 4, 33 Daniela Palombo 34 Lorenzo Pasquini 31 John Pluta 35 Naftali Raz 4 Karen Rodrigue 27 Margaret Schlichting 2 Yee Lee Shing 28, 36 Craig E.L. Stark 37 Trevor Steve 22 Nanthia Suthana 38 Lei Wang 39 Markus Werkle‐bergner 28 Paul Yushkevich 40 Qijing Yu 4 Laura E.M. Wisse 35
Abstract : Introduction: Heterogeneity of segmentation protocols for medial temporal lobe regions and hippo-campal subfields on in vivo magnetic resonance imaging hinders the ability to integrate findings across studies. We aim to develop a harmonized protocol based on expert consensus and histological evidence. Methods: Our international working group, funded by the EU Joint Programme-Neurodegenerative Disease Research (JPND), is working toward the production of a reliable, validated, harmonized protocol for segmentation of medial temporal lobe regions. The working group uses a novel postmortem data set and online consensus procedures to ensure validity and facilitate adoption. Results: This progress report describes the initial results and milestones that we have achieved to date, including the development of a draft protocol and results from the initial reliability tests and consensus procedures. Discussion: A harmonized protocol will enable the standardization of segmentation methods across laboratories interested in medial temporal lobe research worldwide.
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Rosanna Olsen, Valerie Carr, Ana Daugherty, Renaud La Joie, Robert S.C. Amaral, et al.. Progress update from the hippocampal subfields group. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Elsevier, 2019, 11 (1), pp.439-449. ⟨10.1016/j.dadm.2019.04.001⟩. ⟨inserm-02747115⟩

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