Recent advances in our understanding of the organization of dorsal horn neuron populations and their contribution to cutaneous mechanical allodynia - Archive ouverte HAL Access content directly
Journal Articles Journal of Neural Transmission Year : 2020

Recent advances in our understanding of the organization of dorsal horn neuron populations and their contribution to cutaneous mechanical allodynia

(1, 2) , (1, 2) , (2)
1
2

Abstract

The dorsal horns of the spinal cord and the trigeminal nuclei in the brainstem contain neuron populations that are critical to process sensory information. Neurons in these areas are highly heterogeneous in their morphology, molecular phenotype and intrinsic properties, making it difficult to identify functionally distinct cell populations, and to determine how these are engaged in pathophysiological conditions. There is a growing consensus concerning the classification of neuron populations, based on transcriptomic and transductomic analyses of the dorsal horn. These approaches have led to the discovery of several molecularly defined cell types that have been implicated in cutaneous mechanical allodynia, a highly prevalent and difficult-to-treat symptom of chronic pain, in which touch becomes painful. The main objective of this review is to provide a contemporary view of dorsal horn neuronal populations, and describe recent advances in our understanding of on how they participate in cutaneous mechanical allodynia.
Fichier principal
Vignette du fichier
Peirs et al-2020.pdf (2.8 Mo) Télécharger le fichier
Vignette du fichier
Peirs et al-2020 S.pdf (1.79 Mo) Télécharger le fichier
Origin : Publication funded by an institution
Loading...

Dates and versions

inserm-02701538 , version 1 (01-06-2020)

Identifiers

Cite

Cedric Peirs, Radhouane Dallel, Andrew J Todd. Recent advances in our understanding of the organization of dorsal horn neuron populations and their contribution to cutaneous mechanical allodynia. Journal of Neural Transmission, 2020, 127 (4), pp.505-525. ⟨10.1007/s00702-020-02159-1⟩. ⟨inserm-02701538⟩
54 View
69 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More