Skip to Main content Skip to Navigation
Journal articles

Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance

Abstract : Hepatic steatosis is associated with poor cardiometabolic health, with de novo lipogenesis (DNL) contributing to hepatic steatosis and subsequent insulin resistance. Hepatic saturated fatty acids (SFA) may be a marker of DNL and are suggested to be most detrimental in contributing to insulin resistance. Here, we show in a cross-sectional study design (ClinicalTrials.gov ID: NCT03211299) that we are able to distinguish the fractions of hepatic SFA, mono- and polyunsaturated fatty acids in healthy and metabolically compromised volunteers using proton magnetic resonance spectroscopy (1H-MRS). DNL is positively associated with SFA fraction and is elevated in patients with non-alcoholic fatty liver and type 2 diabetes. Intriguingly, SFA fraction shows a strong, negative correlation with hepatic insulin sensitivity. Our results show that the hepatic lipid composition, as determined by our 1H-MRS methodology, is a measure of DNL and suggest that specifically the SFA fraction may hamper hepatic insulin sensitivity.
Complete list of metadata

Cited literature [38 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-02649908
Contributor : Myriam Bodescot Connect in order to contact the contributor
Submitted on : Friday, May 29, 2020 - 12:42:32 PM
Last modification on : Tuesday, May 3, 2022 - 6:26:04 PM

File

s41467-020-15684-0.pdf
Publication funded by an institution

Identifiers

Collections

Citation

Kay H M Roumans, Lucas Lindeboom, Pandichelvam Veeraiah, Carlijn M E Remie, Esther Phielix, et al.. Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance. Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.1891. ⟨10.1038/s41467-020-15684-0⟩. ⟨inserm-02649908⟩

Share

Metrics

Record views

68

Files downloads

67