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Journal articles
Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance
Kay Roumans
1
Lucas Lindeboom
1, 2
Pandichelvam Veeraiah
1, 2
Carlijn Remie
1
Esther Phielix
1
Bas Havekes
2
Yvonne Bruls
1, 2
Martijn Brouwers
2
Marcus Ståhlman
3, 4
Marjan Alssema
5
Harry Peters
5
Renée de Mutsert
6
Bart Staels
7
Marja-Riitta Taskinen
8
Jan Borén
3, 4
Patrick Schrauwen
1
Vera Schrauwen-Hinderling
1, 2, *
*
Corresponding author
Kay H M Roumans 1
Author
Lucas Lindeboom 1, 2
Author
Pandichelvam Veeraiah 1, 2
Author
Carlijn M E Remie 1
Author
Esther Phielix 1
Author
Bas Havekes 2
Author
Yvonne M H Bruls 1, 2
Author
Martijn C G J Brouwers 2
Author
Marcus Ståhlman 3, 4
Author
Marjan Alssema 5
Author
Harry P F Peters 5
Author
Renée de Mutsert 6
Author
Bart Staels 7
Author IdHAL : bart-staels ResearcherId : http://www.researcherid.com/rid/N-9497-2016 ORCID : https://orcid.org/0000-0002-3784-1503
Marja-Riitta Taskinen 8
Author
Jan Borén 3, 4
Author
Patrick Schrauwen 1
Author
Vera B Schrauwen-Hinderling 1, 2
Correspondent author
1
Maastricht University [Maastricht] (Universiteitssingel 40;6200 MD Maastricht - Netherlands)
2
MUMC - Maastricht University Medical Centre (Maastricht - Netherlands)
- Maastricht University [Maastricht] (Universiteitssingel 40;6200 MD Maastricht - Netherlands)
3
GU - University of Gothenburg (Box 100, SE-405 30 Gothenburg - Sweden)
5
Unilever Food Innovation Center [Wageningue, Pays-Bas] (Netherlands)
6
Leiden University Medical Center (LUMC) (Netherlands)
7
RNMCD - Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 (1 rue du Prof Calmette
- 59019 Lille Cedex - France)
- Institut Pasteur de Lille (1 Rue du Professeur Calmette - Lille Cedex - 59019 - France)
- RIIP - Réseau International des Instituts Pasteur (25, rue du Dr Roux 75724 Paris Cedex 15 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1011 (101, rue de Tolbiac, 75013 Paris - France)
- Université de Lille : U1011 (Lille - France)
- CHRU Lille - Centre Hospitalier Régional Universitaire [Lille] (2, avenue Oscar Lambret - 59037 Lille Cedex - France)
8
University of Helsinki (Yliopistonkatu 4, 00100 Helsinki - Finland)
Abstract : Hepatic steatosis is associated with poor cardiometabolic health, with de novo lipogenesis (DNL) contributing to hepatic steatosis and subsequent insulin resistance. Hepatic saturated fatty acids (SFA) may be a marker of DNL and are suggested to be most detrimental in contributing to insulin resistance. Here, we show in a cross-sectional study design (ClinicalTrials.gov ID: NCT03211299) that we are able to distinguish the fractions of hepatic SFA, mono- and polyunsaturated fatty acids in healthy and metabolically compromised volunteers using proton magnetic resonance spectroscopy (1H-MRS). DNL is positively associated with SFA fraction and is elevated in patients with non-alcoholic fatty liver and type 2 diabetes. Intriguingly, SFA fraction shows a strong, negative correlation with hepatic insulin sensitivity. Our results show that the hepatic lipid composition, as determined by our 1H-MRS methodology, is a measure of DNL and suggest that specifically the SFA fraction may hamper hepatic insulin sensitivity.
Document type :
Journal articles
Complete list of metadatas
https://www.hal.inserm.fr/inserm-02649908
Contributor : Myriam Bodescot <>
Submitted on : Friday, May 29, 2020 - 12:42:32 PM
Last modification on : Tuesday, December 15, 2020 - 3:22:04 PM
Contributor : Myriam Bodescot <>
Submitted on : Friday, May 29, 2020 - 12:42:32 PM
Last modification on : Tuesday, December 15, 2020 - 3:22:04 PM
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s41467-020-15684-0.pdf
Publication funded by an institution
Identifiers
- HAL Id : inserm-02649908, version 1
- PUBMED : 32312974
- DOI : 10.1038/s41467-020-15684-0
- PUBMEDCENTRAL : PMC7170906
Collections
INSERM | RIIP | UNIV-LILLE | RNMCD
Citation
Kay Roumans, Lucas Lindeboom, Pandichelvam Veeraiah, Carlijn Remie, Esther Phielix, et al.. Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance. Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.1891. ⟨10.1038/s41467-020-15684-0⟩. ⟨inserm-02649908⟩
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