Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance - Archive ouverte HAL Access content directly
Journal Articles Nature Communications Year : 2020

Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance

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Patrick Schrauwen
  • Function : Author
  • PersonId : 1071601

Abstract

Hepatic steatosis is associated with poor cardiometabolic health, with de novo lipogenesis (DNL) contributing to hepatic steatosis and subsequent insulin resistance. Hepatic saturated fatty acids (SFA) may be a marker of DNL and are suggested to be most detrimental in contributing to insulin resistance. Here, we show in a cross-sectional study design (ClinicalTrials.gov ID: NCT03211299) that we are able to distinguish the fractions of hepatic SFA, mono- and polyunsaturated fatty acids in healthy and metabolically compromised volunteers using proton magnetic resonance spectroscopy (1H-MRS). DNL is positively associated with SFA fraction and is elevated in patients with non-alcoholic fatty liver and type 2 diabetes. Intriguingly, SFA fraction shows a strong, negative correlation with hepatic insulin sensitivity. Our results show that the hepatic lipid composition, as determined by our 1H-MRS methodology, is a measure of DNL and suggest that specifically the SFA fraction may hamper hepatic insulin sensitivity.
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Dates and versions

inserm-02649908 , version 1 (29-05-2020)

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Kay H M Roumans, Lucas Lindeboom, Pandichelvam Veeraiah, Carlijn M E Remie, Esther Phielix, et al.. Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance. Nature Communications, 2020, 11 (1), pp.1891. ⟨10.1038/s41467-020-15684-0⟩. ⟨inserm-02649908⟩
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