Skip to Main content Skip to Navigation
Journal articles

Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance

Abstract : Hepatic steatosis is associated with poor cardiometabolic health, with de novo lipogenesis (DNL) contributing to hepatic steatosis and subsequent insulin resistance. Hepatic saturated fatty acids (SFA) may be a marker of DNL and are suggested to be most detrimental in contributing to insulin resistance. Here, we show in a cross-sectional study design (ClinicalTrials.gov ID: NCT03211299) that we are able to distinguish the fractions of hepatic SFA, mono- and polyunsaturated fatty acids in healthy and metabolically compromised volunteers using proton magnetic resonance spectroscopy (1H-MRS). DNL is positively associated with SFA fraction and is elevated in patients with non-alcoholic fatty liver and type 2 diabetes. Intriguingly, SFA fraction shows a strong, negative correlation with hepatic insulin sensitivity. Our results show that the hepatic lipid composition, as determined by our 1H-MRS methodology, is a measure of DNL and suggest that specifically the SFA fraction may hamper hepatic insulin sensitivity.
Complete list of metadatas

Cited literature [38 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-02649908
Contributor : Myriam Bodescot <>
Submitted on : Friday, May 29, 2020 - 12:42:32 PM
Last modification on : Tuesday, September 1, 2020 - 3:46:09 PM

File

s41467-020-15684-0.pdf
Publication funded by an institution

Identifiers

Collections

Citation

Kay Roumans, Lucas Lindeboom, Pandichelvam Veeraiah, Carlijn Remie, Esther Phielix, et al.. Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance. Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.1891. ⟨10.1038/s41467-020-15684-0⟩. ⟨inserm-02649908⟩

Share

Metrics

Record views

43

Files downloads

65