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Gliotransmitters Travel in Time and Space

Abstract : The identification of the presence of active signaling between astrocytes and neurons in a process termed gliotransmission has caused a paradigm shift in our thinking about brain function. However, we are still in the early days of the conceptualization of how astrocytes influence synapses, neurons, networks, and ultimately behavior. In this Perspective, our goal is to identify emerging principles governing gliotransmission and consider the specific properties of this process that endow the astrocyte with unique functions in brain signal integration. We develop and present hypotheses aimed at reconciling confounding reports and define open questions to provide a conceptual framework for future studies. We propose that astrocytes mainly signal through high-affinity slowly desensitizing receptors to modulate neurons and perform integration in spatiotemporal domains complementary to those of neurons.
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https://www.hal.inserm.fr/inserm-02647586
Contributor : Stephane Oliet <>
Submitted on : Friday, May 29, 2020 - 7:29:40 AM
Last modification on : Monday, August 31, 2020 - 4:24:30 PM

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Alfonso Araque, Giorgio Carmignoto, Philip Haydon, Stéphane H.R. Oliet, Richard Robitaille, et al.. Gliotransmitters Travel in Time and Space. Neuron, Elsevier, 2014, 81 (4), pp.728-739. ⟨10.1016/j.neuron.2014.02.007⟩. ⟨inserm-02647586⟩

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