Dendritic cells and the control of immunity, Nature, vol.392, pp.245-252, 1998. ,
Tolerogenic dendritic cells, Annu Rev. Immunol, vol.21, pp.685-711, 2003. ,
Dendritic-cell-based therapeutic cancer vaccines, Immunity, vol.39, pp.38-48, 2013. ,
Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cells, J. Exp. Med, vol.207, pp.1273-1281, 2010. ,
The XC chemokine receptor 1 is a conserved selective marker of mammalian cells homologous to mouse CD8alpha+ dendritic cells, J. Exp. Med, vol.207, pp.1283-1292, 2010. ,
URL : https://hal.archives-ouvertes.fr/hal-00493468
BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens, J. Exp. Med, vol.141, pp.1247-1260, 2010. ,
Restricted dendritic cell and monocyte progenitors in human cord blood and bone marrow, J. Exp. Med, vol.212, pp.385-399, 2015. ,
Dendritic cell lineage potential in human early hematopoietic progenitors, Cell Rep, vol.20, pp.529-537, 2017. ,
Lineage specification of human dendritic cells is marked by IRF8 expression in hematopoietic stem cells and multipotent progenitors, Nat. Immunol, vol.18, pp.877-888, 2017. ,
Circulating precursors of human CD1c+ and CD141+ dendritic cells, J. Exp. Med, vol.212, pp.401-413, 2015. ,
Human dendritic cells (DCs) are derived from distinct circulating precursors that are precommitted to become CD1c+ or CD141+ DCs, J. Exp. Med, vol.213, pp.2861-2870, 2016. ,
Mapping the human DC lineage through the integration of highdimensional techniques, Science, vol.356, p.3009, 2017. ,
DNGR-1 is a specific and universal marker of mouse and human Batf3-dependent dendritic cells in lymphoid and nonlymphoid tissues, Blood, vol.119, pp.6052-6062, 2012. ,
Type I interferons produced by dendritic cells promote their phenotypic and functional activation, Blood, vol.99, pp.3263-3271, 2002. ,
Human tissues contain CD141hi cross-presenting dendritic cells with functional homology to mouse CD103+ nonlymphoid dendritic cells, Immunity, vol.37, pp.60-73, 2012. ,
IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL ? 17 cytokine responses, Immunity, vol.38, pp.970-983, 2013. ,
IFN regulatory factor-4 and -8 govern dendritic cell subset development and their functional diversity, J. Immunol, vol.174, pp.2573-2581, 2005. ,
Human inflammatory dendritic cells induce Th17 cell differentiation, Immunity, vol.38, pp.336-348, 2013. ,
Characterization of resident and migratory dendritic cells in human lymph nodes, J. Exp. Med, vol.209, pp.653-660, 2012. ,
URL : https://hal.archives-ouvertes.fr/hal-00723792
Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors, Science, vol.356, p.4573, 2017. ,
Sl/Sld hematopoietic progenitors are deficient in situ, Exp. Hematol, vol.22, pp.174-177, 1994. ,
Early transplantation to a normal microenvironment prevents the development of Steel hematopoietic stem cell defects, Exp. Hematol, vol.25, pp.542-547, 1997. ,
CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance, Nature, vol.495, pp.227-230, 2013. ,
Chemokine receptor CXCR4-dependent internalization and resecretion of functional chemokine SDF-1 by bone marrow endothelial and stromal cells, Nat. Immunol, vol.6, pp.1038-1046, 2005. ,
Critical role of thrombopoietin in maintaining adult quiescent hematopoietic stem cells, Cell Stem Cell, vol.1, pp.671-684, 2007. ,
Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche, Cell Stem Cell, vol.1, pp.685-697, 2007. ,
Hematopoietic stem cell niche maintenance during homeostasis and regeneration, Nat. Med, vol.20, pp.833-846, 2014. ,
Inflammatory Flt3l is essential to mobilize dendritic cells and for T cell responses during Plasmodium infection, Nat. Med, vol.19, pp.730-738, 2013. ,
Dendritic cell homeostasis is maintained by nonhematopoietic and T-cell-produced Flt3-ligand in steady state and during immune responses, Eur. J. Immunol, vol.43, pp.1651-1658, 2013. ,
Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells, Proc. Natl Acad. Sci. USA, vol.107, pp.9759-9764, 2010. ,
The origin and development of nonlymphoid tissue CD103 + DCs, J. Exp. Med, vol.206, pp.3115-3130, 2009. ,
Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks, Nat. Immunol, vol.13, pp.499-510, 2012. ,
The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues, Nat. Immunol, vol.9, pp.676-683, 2008. ,
Origin of dendritic cells in peripheral lymphoid organs of mice, Nat. Immunol, vol.8, pp.578-583, 2007. ,
GM-CSF and TNF-alpha cooperate in the generation of dendritic Langerhans cells, Nature, vol.360, pp.258-261, 1992. ,
Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha, J. Exp. Med, vol.179, pp.1109-1118, 1994. ,
The equivalents of human blood and spleen dendritic cell subtypes can be generated in vitro from human CD34(+) stem cells in the presence of fms-like tyrosine kinase 3 ligand and thrombopoietin, Cell. Mol. Immunol, vol.9, pp.446-454, 2012. ,
Human XCR1+ dendritic cells derived in vitro from CD34+ progenitors closely resemble blood dendritic cells, including their adjuvant responsiveness, contrary to monocyte-derived dendritic cells, J. Immunol, vol.193, pp.1622-1635, 2014. ,
Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8alpha+ dendritic cells, J. Exp. Med, vol.207, pp.1261-1271, 2010. ,
Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor: a proliferative factor for primitive hematopoietic cells, Cell, vol.75, pp.1157-1167, 1993. ,
Human FLT3/FLK2 receptor tyrosine kinase is expressed at the surface of normal and malignant hematopoietic cells, Leukemia, vol.10, pp.238-248, 1996. ,
Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells, Blood, vol.95, pp.3489-3497, 2000. ,
Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified, J. Exp. Med, vol.184, pp.1953-1962, 1996. ,
Flt3-ligand and granulocyte colony-stimulating factor mobilize distinct human dendritic cell subsets in vivo, J. Immunol, vol.165, pp.566-572, 2000. ,
Activation of the Flt3 signal transduction cascade rescues and enhances type I interferon-producing and dendritic cell development, J. Exp. Med, vol.203, pp.227-238, 2006. ,
Notch signaling facilitates in vitro generation of crosspresenting classical dendritic cells, Cell Rep, vol.23, pp.3658-3672, 2018. ,
Large-scale human dendritic cell differentiation revealing Notch-dependent lineage bifurcation and heterogeneity, Cell Rep, vol.24, 1902. ,
URL : https://hal.archives-ouvertes.fr/hal-02399836
FLT3-ligand treatment of humanized mice results in the generation of large numbers of CD141+ and CD1c+ dendritic cells in vivo, J. Immunol, vol.192, pp.1982-1989, 2014. ,
A novel Flt3-deficient HIS mouse model with selective enhancement of human DC development, Eur. J. Immunol, vol.46, pp.1291-1299, 2016. ,
Human CD1c+ dendritic cells drive the differentiation of CD103+ CD8+ mucosal effector T cells via the cytokine TGF-beta, Immunity, vol.38, pp.818-830, 2013. ,
Reproducible establishment of hemopoietic supportive stromal cell lines from murine bone marrow, Exp. Hematol, vol.17, pp.145-153, 1989. ,
Generation of lymphohematopoietic cells from embryonic stem cells in culture, Science, vol.265, pp.1098-1101, 1994. ,
Endothelial and perivascular cells maintain haematopoietic stem cells, Nature, vol.481, pp.457-462, 2012. ,
CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+TNF alpha, J. Exp. Med, vol.184, pp.695-706, 1996. ,
High-dimensional phenotypic mapping of human dendritic cells reveals interindividual variation and tissue specialization, Immunity, vol.47, p.1036, 2017. ,
Differential development of murine dendritic cells by GM-CSF versus Flt3 ligand has implications for inflammation and trafficking, J. Immunol, vol.179, pp.7577-7584, 2007. ,
Cutting edge: generation of splenic CD8+ and CD8-dendritic cell equivalents in Fms-like tyrosine kinase 3 ligand bone marrow cultures, J. Immunol, vol.174, pp.6592-6597, 2005. ,
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles, Proc. Natl Acad. Sci. USA, vol.102, pp.15545-15550, 2005. ,
BubbleGUM: automatic extraction of phenotype molecular signatures and comprehensive visualization of multiple Gene Set Enrichment Analyses, BMC Genomics, vol.16, p.814, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-01236135
Human dermal CD14(+) cells are a transient population of monocyte-derived macrophages, Immunity, vol.41, pp.465-477, 2014. ,
Evaluation of UMAP as an alternative to t-SNE for single-cell data, 2018. ,
Human blood CD1c+ dendritic cells encompass CD5high and CD5low subsets that differ significantly in phenotype, gene expression, and functions, J. Immunol, vol.198, pp.1553-1564, 2017. ,
Single-cell analysis of human mononuclear phagocytes reveals subset-defining markers and identifies circulating inflammatory dendritic cells, Immunity, vol.51, p.578, 2019. ,
Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance, J. Exp. Med, vol.196, pp.1627-1638, 2002. ,
Support of human hematopoiesis in long-term bone marrow cultures by murine stromal cells selectively expressing the membrane-bound and secreted forms of the human homolog of the steel gene product, stem cell factor, Proc. Natl Acad. Sci. USA, vol.89, pp.7350-7354, 1992. ,
Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation, Blood, vol.119, pp.2768-2777, 2012. ,
Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency, Nat. Immunol, vol.19, pp.973-985, 2018. ,
Development and function of human innate immune cells in a humanized mouse model, Nat. Biotechnol, vol.32, pp.364-372, 2014. ,
NOD/SCID mice engineered to express human IL ? 3, GM-CSF and Steel factor constitutively mobilize engrafted human progenitors and compromise human stem cell regeneration, Leukemia, vol.18, pp.341-347, 2004. ,
Establishment of a human allergy model using human IL-3/GM-CSF-transgenic NOG mice, J. Immunol, vol.191, pp.2890-2899, 2013. ,
Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung, Proc. Natl Acad. Sci. USA, vol.108, pp.2390-2395, 2011. ,
Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/ CXCL12 secretion, Cell, vol.121, pp.335-348, 2005. ,
STAR: ultrafast universal RNA-seq aligner, Bioinformatics, vol.29, pp.15-21, 2013. ,
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2, Genome Biol, vol.15, p.550, 2014. ,
Controlling the false discovery rate: a practical and powerful approach to multiple testing, J. R. Stat. Soc. B Methodol, vol.57, pp.289-300, 1995. ,
ggplot2: elegant graphics for data analysis, 2009. ,
ConsensusPathDB-a database for integrating human functional interaction networks, Nucleic Acids Res, vol.37, pp.623-628, 2009. ,
High-dimensional analysis of the murine myeloid cell system, Nat. Immunol, vol.15, pp.1181-1189, 2014. ,
Normalization of mass cytometry data with bead standards, Cytom. A, vol.83, pp.483-494, 2013. ,
Cytometry by time-of-flight shows combinatorial cytokine expression and virus-specific cell niches within a continuum of CD8+ T cell phenotypes, Immunity, vol.36, pp.142-152, 2012. ,
Logicle" display method avoids deceptive effects of logarithmic scaling for low signals and compensated data, Cytom. A, vol.69, pp.541-551, 2006. ,
UMAP: uniform manifold approximation and projection for dimension reduction, 2018. ,