Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Ca, Cancer J. Clin, vol.68, pp.394-424, 2018. ,
Integrative genomic profiling of human prostate cancer, Cancer Cell, vol.18, pp.11-22, 2010. ,
Integrative clinical genomics of advanced prostate cancer, Cell, vol.161, pp.1215-1228, 2015. ,
Functional screen identifies kinases driving prostate cancer visceral and bone metastasis, Proc. Natl Acad. Sci, vol.113, pp.172-181, 2016. ,
Phosphoproteome integration reveals patient-specific networks in prostate cancer, Cell, vol.166, pp.1041-1054, 2016. ,
Prostatic intraepithelial neoplasia and intestinal metaplasia in prostates of probasin-RAS transgenic mice, Prostate, vol.59, pp.448-459, 2004. ,
Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer, Cancer Cell, vol.4, pp.209-221, 2003. ,
Pten loss and RAS/MAPK activation cooperate to promote EMT and metastasis initiated from prostate cancer stem/progenitor cells, Cancer Res, vol.72, pp.1878-1889, 2012. ,
B-Raf activation cooperates with PTEN loss to drive c-Myc expression in advanced prostate cancer, Cancer Res, vol.72, pp.4765-4776, 2012. ,
PTEN loss and activation of K-RAS and beta-catenin cooperate to accelerate prostate tumourigenesis, J. Pathol, vol.243, pp.442-456, 2017. ,
Tumour cell invasion: an emerging role for basal epithelial cell extrusion, Nat. Rev. Cancer, vol.14, pp.495-501, 2014. ,
The forces and fates of extruding cells, Curr. Opin. Cell Biol, vol.54, pp.66-71, 2018. ,
Src-transformed cells hijack mitosis to extrude from the epithelium, Nat. Commun, vol.9, p.4695, 2018. ,
p120 catenin suppresses basal epithelial cell extrusion in invasive pancreatic neoplasia, Cancer Res, vol.76, pp.3351-3363, 2016. ,
the golden bug, emerges as a tool for human genetics, Nat. Rev. Genet, vol.6, pp.9-23, 2005. ,
Signaling by the Drosophila epidermal growth factor receptor pathway during development, Exp. Cell Res, vol.284, pp.140-149, 2003. ,
The conserved PI3?K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila, Oncogene, vol.19, pp.3971-3977, 2000. ,
A Drosophila model for EGFR-Ras and PI3K-dependent human glioma, PLoS Genet, vol.5, p.1000374, 2009. ,
Drosophila melanogaster as a model system for human brain cancers, Glia, vol.59, pp.1364-1376, 2011. ,
Drosophila lung cancer models identify trametinib plus statin as candidate therapeutic, Cell Rep, vol.14, pp.1477-1487, 2016. ,
Functional exploration of colorectal cancer genomes using Drosophila, Nat. Commun, vol.7, p.13615, 2016. ,
Dual role of the Pax gene paired in accessory gland development of Drosophila, Development, vol.129, pp.339-346, 2002. ,
Binucleation of accessory gland lobe contributes to effective ejection of seminal fluid in Drosophila melanogaster, Zool. Sci, vol.35, pp.446-458, 2018. ,
Histological variants of prostatic carcinoma and their significance, Histopathology, vol.60, pp.59-74, 2012. ,
A genetic screen in Drosophila for regulators of human prostate cancer progression, Biochem. Biophys. Res. Commun, vol.451, pp.548-555, 2014. ,
The Drosophila accessory gland as a model for prostate cancer and other pathologies, Curr. Top. developmental Biol, vol.121, pp.339-375, 2017. ,
Cell adhesion molecules and cancer, Curr. Opin. Oncol, vol.4, pp.142-150, 1992. ,
A genetic screen in drosophila for metastatic behavior, Science, vol.302, pp.1227-1231, 2003. ,
Epithelial-to-mesenchymal transition in prostate cancer: paradigm or puzzle?, Nat. Rev. Urol, vol.8, pp.428-439, 2011. ,
c-Srcmediated epithelial cell migration and invasion regulated by PDZ binding site, Mol. Cell. Biol, vol.28, pp.642-655, 2008. ,
Src signaling pathways in prostate cancer, Cancer Metastasis Rev, vol.33, pp.595-606, 2014. ,
Src cooperates with oncogenic Ras in Ttumourigenesis via the JNK and PI3K pathways in Drosophila epithelial tissue, Int. J. Mol. Sci, vol.19, p.1585, 2018. ,
Invasive prostate carcinoma driven by c-Src and androgen receptor synergy, Cancer Res, vol.71, pp.862-872, 2011. ,
Cell autonomy of HIF effects in Drosophila: tracheal cells sense hypoxia and induce terminal branch sprouting, Dev. Cell, vol.14, pp.547-558, 2008. ,
Multiple strategies of oxygen supply in Drosophila malignancies identify tracheogenesis as a novel cancer hallmark, Sci. Rep, vol.5, p.9061, 2015. ,
Control of airway tube diameter and integrity by secreted chitin-binding proteins in Drosophila, PLoS One, vol.8, p.67415, 2013. ,
Drosophila matrix metalloproteinases are required for tissue remodeling, but not embryonic development, Dev. Cell, vol.4, pp.95-106, 2003. ,
A matrix metalloproteinase mediates airway remodeling in Drosophila, Dev. Biol, vol.344, pp.772-783, 2010. ,
A protein trap strategy to detect GFP-tagged proteins expressed from their endogenous loci in Drosophila, Proc. Natl Acad. Sci. U. S. A, vol.98, pp.15050-15055, 2001. ,
Regulation of cellular growth by the Drosophila target of rapamycin dTOR, Genes Dev, vol.14, pp.2712-2724, 2000. ,
The Drosophila spitz gene encodes a putative EGF-like growth factor involved in dorsalventral axis formation and neurogenesis, Genes Dev, vol.6, pp.1503-1517, 1992. ,
Epidermal growth factor receptor: mechanisms of activation and signalling, Exp. Cell Res, vol.284, pp.31-53, 2003. ,
The EGFR ligands Spitz and Keren act cooperatively in the Drosophila eye, Dev. Biol, vol.307, pp.105-113, 2007. ,
Guidance of cell migration by EGF receptor signaling during Drosophila oogenesis, Science, vol.291, pp.131-133, 2001. ,
An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control, Curr. Biol, vol.11, pp.213-221, 2001. ,
Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage, Cancer Res, vol.59, pp.4291-4296, 1999. ,
The effect on the insulin-like growth factor system in human prostate epithelial cells of immortalization and transformation by simian virus-40 T antigen, J. Clin. Endocrinol. Metab, vol.81, pp.3709-3716, 1996. ,
Systematic functional annotation of somatic mutations in cancer, Cancer Cell, vol.33, 2018. ,
Direct inhibition of oncogenic KRAS by hydrocarbonstapled SOS1 helices, Proc. Natl Acad. Sci. Usa, vol.112, pp.1761-1766, 2015. ,
Autophagy in oncogenic K-Ras promotes basal extrusion of epithelial cells by degrading S1P, Curr. Biol, vol.24, pp.19-28, 2014. ,
The orthologous Tbx transcription factors Omb and TBX2 induce epithelial cell migration and extrusion in vivo without involvement of matrix metalloproteinases, Oncotarget, vol.5, pp.11998-12015, 2014. ,
Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health, Oncotarget, vol.2, pp.135-164, 2011. ,
Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance, Adv. Enzym. Regul, vol.46, pp.249-279, 2006. ,
The Akt/mTOR and mitogenactivated protein kinase pathways in lung cancer therapy, J. Thorac. Oncol, vol.1, pp.749-751, 2006. ,
Dual inhibition of MEK and PI3K pathway in KRAS and BRAF mutated colorectal cancers, Int. J. Mol. Sci, vol.16, pp.22976-22988, 2015. ,
The molecular background of mucinous carcinoma beyond MUC2, J. Pathol. Clin. Res, vol.1, pp.3-17, 2015. ,
Targeting the PI3K/AKT/mTOR and Raf/MEK/ERK pathways in the treatment of breast cancer, Cancer Treatment Rev, 2013. ,
The molecular taxonomy of primary prostate cancer, Cell, vol.163, pp.1011-1025, 2015. ,
Comparative analysis of mRNA and protein expression for epidermal growth factor receptor and ligands relative to the proliferative index in human prostate tissue, Hum. Pathol, vol.27, pp.688-694, 1996. ,
Epidermal growth factor-related peptides and the epidermal growth factor receptor in normal and malignant prostate, World J. Urol, vol.13, pp.290-296, 1995. ,
Endogenous secretion of epidermal growth factor peptides stimulates growth of DU145 prostate cancer cells, Cancer Lett, vol.60, pp.109-112, 1991. ,
Epidermal growth factor (EGF) receptor blockade inhibits the action of EGF, insulin-like growth factor I, and a protein kinase A activator on the mitogen-activated protein kinase pathway in prostate cancer cell lines, Cancer Res, vol.59, pp.227-233, 1999. ,
The role of EGFrelated peptides in tumor growth, Front. Biosci, vol.6, pp.685-707, 2001. ,
A phase II trial of gefitinib in patients with non-metastatic hormone-refractory prostate cancer, BJU Int, vol.100, pp.765-769, 2007. ,
A multicenter phase II clinical trial of lapatinib (GW572016) in hormonally untreated advanced prostate cancer, Am. J. Clin. Oncol, vol.33, pp.609-613, 2010. ,
A phase II trial of docetaxel and erlotinib as first-line therapy for elderly patients with androgen-independent prostate cancer, BMC Cancer, vol.7, p.142, 2007. ,
A randomized phase II efficacy and safety study of vandetanib (ZD6474) in combination with bicalutamide versus bicalutamide alone in patients with chemotherapy naive castration-resistant prostate cancer, Invest. N. Drugs, vol.32, pp.746-752, 2014. ,
Molecular genetics of prostate cancer, Genes Dev, vol.14, pp.2410-2434, 2000. ,
A fat body-derived IGF-like peptide regulates postfeeding growth in Drosophila, Dev. Cell, vol.17, pp.885-891, 2009. ,
Impaired Wnt signaling in dopamine containing neurons is associated with pathogenesis in a rotenone triggered Drosophila Parkinson's disease model, Sci. Rep, vol.8, p.2372, 2018. ,