The weekend effect in kidney transplantation outcomes: a French cohort‐based study

Simon Ville; Julien Branchereau; Adeline Cornuaud; Jacques Dantal; Christophe Legendre; Fanny Buron; Emmanuel Morelon; Valérie Garrigue; Moglie Lequentrec; Laetitia Albano; Elisabeth Cassuto; Sophie Girerd; Marc Ladrière; Denis Glotz; Carmen Lefaucher; Clarisse Kerleau; Yohann Foucher; Magali Giral

doi:10.1111/tri.13653

Journal articles

The weekend effect in kidney transplantation outcomes: a French cohort‐based study

Simon Ville ^{1, 2} Julien Branchereau ^{1, 2} Adeline Cornuaud ³ Jacques Dantal ^{1, 2} Christophe Legendre ^{4, 5} Fanny Buron ⁶ Emmanuel Morelon ⁶ Valérie Garrigue ⁷ Moglie Lequentrec ⁷ Laetitia Albano ⁸ Elisabeth Cassuto ⁸ Sophie Girerd ⁹ Marc Ladrière ⁹ Denis Glotz ¹⁰ Carmen Lefaucher ¹⁰ Clarisse Kerleau ^{1, 2} Yohann Foucher ^{1, 2} Magali Giral ^{1, 5, 11, *}

* Corresponding author

1 U1064 Inserm - CRTI - Centre de Recherche en Transplantation et Immunologie

2 SPHERE - MethodS in Patients-centered outcomes and HEalth ResEarch

3 CHU Nantes - Centre hospitalier universitaire de Nantes

4 Département de Néphrologie [CHU Necker]

5 Kidney Transplant Center [CHU Necker]

6 Service de Transplantation, Néphrologie et Immunologie Clinique [Hôpital Edouard Herriot, HCL]

7 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]

8 CHU Nice - Centre Hospitalier Universitaire de Nice

9 Service de Néphrologie [CHRU Nancy]

10 Service de Néphrologie [Saint-Louis]

11 Fondation, Centre d’Investigation Clinique en Biothérapie - Réseau CENTAURE [CHU Nantes]

Abstract : Background: Numerous studies have reported a weekend effect on outcomes for diseases treated at hospitals. No study has been conducted in France for kidney transplantation. We therefore performed a cohort-based study to evaluate whether outcomes of kidney transplant recipients display a weekend effect. Methods: Data were extracted from the French DIVAT cohort. Patients aged 18 years and older, transplanted with a single kidney from deceased donors between 2005 and 2017 were studied. Linear regression, logistic regression and cause specific Cox model were used. Results: Among the 6652 studied patients, 4653 patients were transplanted during weekdays (69.9%) versus 1999 during weekends (30.1%). The only statistically significant difference was the percentage of patients with vascular surgical complication(s) at 30 days: 13.3% in the weekend group versus 16.2% in the weekday group 0.79 (95% CI: 0.68; 0.92). We did not observe other significant differences for the other outcomes: patient or graft survival, the risk of acute rejection episodes, the 30-day percentage of urological complications, and the 1-year estimated glomerular filtration rate. Conclusion: Our study highlights a small protective weekend effect with less post-surgery vascular complications compared to weekdays. This paradox might be explained by a different handling of weekend transplantations.

Keywords : Kidney transplantation cohort-based analysis weekend effect

Document type :

Journal articles

Domain :

Life Sciences [q-bio]

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https://www.hal.inserm.fr/inserm-02626392
Contributor : Christine Dupuis <>
Submitted on : Tuesday, May 26, 2020 - 5:16:19 PM
Last modification on : Wednesday, August 19, 2020 - 11:19:04 AM

The weekend effect in kidney transplantation outcomes: a French cohort‐based study

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The weekend effect in kidney transplantation outcomes: a French cohort‐based study

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