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The weekend effect in kidney transplantation outcomes: a French cohort‐based study

Simon Ville 1, 2 Julien Branchereau 1, 2 Adeline Cornuaud 3 Jacques Dantal 1, 2 Christophe Legendre 4, 5 Fanny Buron 6 Emmanuel Morelon 6 Valérie Garrigue 7 Moglie Lequentrec 7 Laetitia Albano 8 Elisabeth Cassuto 8 Sophie Girerd 9 Marc Ladrière 9 Denis Glotz 10 Carmen Lefaucher 10 Clarisse Kerleau 1, 2 Yohann Foucher 1, 2 Magali Giral 1, 5, 11, *
* Corresponding author
1 U1064 Inserm - CRTI - Centre de Recherche en Transplantation et Immunologie
2 SPHERE - MethodS in Patients-centered outcomes and HEalth ResEarch
3 CHU Nantes - Centre hospitalier universitaire de Nantes
4 Département de Néphrologie [CHU Necker]
5 Kidney Transplant Center [CHU Necker]
6 Service de Transplantation, Néphrologie et Immunologie Clinique [Hôpital Edouard Herriot, HCL]
7 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
8 CHU Nice - Centre Hospitalier Universitaire de Nice
9 Service de Néphrologie [CHRU Nancy]
10 Service de Néphrologie [Saint-Louis]
11 Fondation, Centre d’Investigation Clinique en Biothérapie - Réseau CENTAURE [CHU Nantes]
Abstract : Background: Numerous studies have reported a weekend effect on outcomes for diseases treated at hospitals. No study has been conducted in France for kidney transplantation. We therefore performed a cohort-based study to evaluate whether outcomes of kidney transplant recipients display a weekend effect. Methods: Data were extracted from the French DIVAT cohort. Patients aged 18 years and older, transplanted with a single kidney from deceased donors between 2005 and 2017 were studied. Linear regression, logistic regression and cause specific Cox model were used. Results: Among the 6652 studied patients, 4653 patients were transplanted during weekdays (69.9%) versus 1999 during weekends (30.1%). The only statistically significant difference was the percentage of patients with vascular surgical complication(s) at 30 days: 13.3% in the weekend group versus 16.2% in the weekday group 0.79 (95% CI: 0.68; 0.92). We did not observe other significant differences for the other outcomes: patient or graft survival, the risk of acute rejection episodes, the 30-day percentage of urological complications, and the 1-year estimated glomerular filtration rate. Conclusion: Our study highlights a small protective weekend effect with less post-surgery vascular complications compared to weekdays. This paradox might be explained by a different handling of weekend transplantations.
Keywords : Kidney transplantation cohort-based analysis weekend effect
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Journal articles
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https://www.hal.inserm.fr/inserm-02626392
Contributor : Christine Dupuis <>
Submitted on : Tuesday, May 26, 2020 - 5:16:19 PM
Last modification on : Tuesday, July 20, 2021 - 6:40:03 PM

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INSERM | HCL | HEH | UNIV-NANTES | CRTI | SORBONNE-UNIVERSITE | UNIV-TOURS | UNIV-PARIS | SPHERE_HEALTH_RESEARCH

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Simon Ville, Julien Branchereau, Adeline Cornuaud, Jacques Dantal, Christophe Legendre, et al.. The weekend effect in kidney transplantation outcomes: a French cohort‐based study. Transplant International, Wiley, 2020, Online ahead of print. ⟨10.1111/tri.13653⟩. ⟨inserm-02626392⟩

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