A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen, J. Biol. Chem, vol.268, pp.10932-10937, 1993. ,
A novel domain within the 55 kd TNF receptor signals cell death, Cell, vol.74, pp.845-853, 1993. ,
A null mutation in the perforin gene impairs cytolytic T lymphocyte-and natural killer cell-mediated cytotoxicity, Proc. Natl. Acad. Sci, vol.91, pp.11571-11575, 1994. ,
Antigen presented by tumors in vivo determines the nature of CD8+ T-cell cytotoxicity, Cancer Res, vol.69, pp.6615-6623, 2009. ,
NK cells switch from granzyme B to death receptor-mediated cytotoxicity during serial killing, J. Exp. Med, vol.216, pp.2113-2127, 2019. ,
Role of TNF-alpha in CD8+ cytotoxic T lymphocyte-mediated lysis, J. Immunol, vol.150, pp.4303-4314, 1993. ,
Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity, Science, vol.265, pp.528-530, 1994. ,
Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways, Nature, vol.370, pp.650-652, 1994. ,
Involvement of Fas ligand and Fas-mediated pathway in the cytotoxicity of human natural killer cells, J. Immunol, vol.157, pp.2909-2915, 1996. ,
Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells, Nat. Med, vol.7, pp.94-100, 2001. ,
Tumor immune evasion arises through loss of TNF sensitivity, Sci. Immunol, vol.3, 2018. ,
Tumorigenic and Immunosuppressive Effects of Endoplasmic Reticulum Stress in Cancer, vol.168, pp.692-706, 2017. ,
Endoplasmic Reticulum Stress and the Hallmarks of Cancer, Trends Cancer, vol.2, pp.252-262, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01308007
Emerging Roles of the Endoplasmic Reticulum Associated Unfolded Protein Response in Cancer Cell Migration and Invasion, Cancers, vol.11, p.631, 2019. ,
URL : https://hal.archives-ouvertes.fr/hal-02160375
The role of the unfolded protein response in cancer progression: From oncogenesis to chemoresistance, Biol. Cell, vol.111, pp.1-17, 2019. ,
URL : https://hal.archives-ouvertes.fr/hal-02379638
Cancer cell-autonomous TRAIL-R signaling promotes KRAS-driven cancer progression, invasion, and metastasis, Cancer Cell, vol.27, pp.561-573, 2015. ,
Decoding the sweet regulation of apoptosis: The role of glycosylation and galectins in apoptotic signaling pathways, Cell Death Differ, vol.26, pp.981-993, 2019. ,
Palmitoylation is required for efficient Fas cell death signaling, EMBO J, vol.26, pp.209-220, 2007. ,
URL : https://hal.archives-ouvertes.fr/hal-00165458
Palmitoylation of CD95 facilitates formation of SDS-stable receptor aggregates that initiate apoptosis signaling, EMBO J, vol.26, pp.221-231, 2007. ,
Fas/CD95 prevents autoimmunity independently of lipid raft localization and efficient apoptosis induction, Nat. Commun, 2016. ,
S-Nitrosylation in TNF superfamily signaling pathway: Implication in cancer, Redox Biol, vol.6, pp.507-515, 2015. ,
The biological activity of FasL in human and mouse lungs is determined by the structure of its stalk region, J. Clin. Investig, vol.121, pp.1174-1190, 2011. ,
RIPK1 Kinase-Dependent Death: A Symphony of Phosphorylation Events, Trends Cell Biol, 2020. ,
Paving TRAIL's Path with Ubiquitin, Trends Biochem. Sci, vol.43, pp.44-60, 2018. ,
Membrane-bound Fas ligand only is essential for Fas-induced apoptosis, Nature, vol.461, pp.659-663, 2009. ,
Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis, Nature, vol.574, pp.428-431, 2019. ,
A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1, Nature, vol.2020, pp.109-114 ,
Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease, Nature, vol.577, pp.103-108, 2020. ,
,
Shock and tissue injury induced by recombinant human cachectin, Science, vol.234, pp.470-474, 1986. ,
Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes, Cell, vol.114, pp.181-190, 2003. ,
URL : https://hal.archives-ouvertes.fr/inserm-00527105
SPATA2: More than a missing link, Cell Death Differ, vol.24, pp.1142-1147, 2017. ,
TBK1 and IKKepsilon prevent TNF-induced cell death by RIPK1 phosphorylation, Nat. Cell. Biol, vol.20, pp.1389-1399, 2018. ,
TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in, Aging. Cell, vol.174, pp.1477-1491, 2018. ,
Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2, Mol. Cell, vol.69, pp.566-580, 2018. ,
, NF-?B-Independent Role of IKK?/IKK? in Preventing RIPK1
, Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling, Mol. Cell, vol.60, pp.63-76, 2015.
Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation, Nat. Commun, vol.10, p.1729, 2019. ,
MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death, Nat. Cell. Biol, vol.19, pp.1237-1247, 2017. ,
MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death, Mol. Cell, 2017. ,
p38MAPK/MK2-dependent phosphorylation controls cytotoxic RIPK1 signalling in inflammation and infection, Nat. Cell. Biol, vol.19, pp.1248-1259, 2017. ,
Suppression of TNF-alpha-induced apoptosis by NF-kappaB, Science, vol.274, pp.787-789, 1996. ,
Dying cells actively regulate adaptive immune responses, Nat. Rev. Immunol, vol.17, pp.262-275, 2017. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01491773
The Diversification of Cell Death and Immunity: Memento Mori, Mol. Cell, vol.76, pp.232-242, 2019. ,
Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule, Nat. Immunol, vol.1, pp.489-495, 2000. ,
TRAIL induces receptor-interacting protein 1-dependent and caspase-dependent necrosis-like cell death under acidic extracellular conditions, Cancer Res, vol.67, pp.218-226, 2007. ,
URL : https://hal.archives-ouvertes.fr/hal-00690349
Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment, J. Cell Biol, vol.187, pp.1037-1054, 2009. ,
TRAF2 inhibits TRAIL-and CD95L-induced apoptosis and necroptosis, Cell Death Dis, vol.5, 1444. ,
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury, Nat. Chem. Biol, vol.1, pp.112-119, 2005. ,
The Structural Basis of Necroptotic Cell Death Signaling, Trends Biochem. Sci, vol.44, pp.53-63, 2019. ,
Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics, Cell Res, vol.25, pp.707-725, 2015. ,
Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity, Cell Rep, vol.15, pp.274-287, 2016. ,
Necroptosis promotes cell-autonomous activation of proinflammatory cytokine gene expression, Cell Death Dis, vol.9, p.500, 2018. ,
Necroptosis suppresses inflammation via termination of TNF-or LPS-induced cytokine and chemokine production, Cell Death Differ, vol.22, pp.1313-1327, 2015. ,
Pannexin-1 limits the production of proinflammatory cytokines during necroptosis, EMBO Rep, vol.20, 2019. ,
URL : https://hal.archives-ouvertes.fr/inserm-02281304
Quantitative and Dynamic Catalogs of Proteins Released during Apoptotic and Necroptotic Cell Death, Cell Rep, vol.30, pp.1260-1270, 2020. ,
, Cell Membrane Integrity. Cell Rep, vol.28, pp.2275-2287, 2019.
Activation of cell-surface proteases promotes necroptosis, inflammation and cell migration, Cell Res, vol.26, pp.886-900, 2016. ,
Metabolites released from apoptotic cells act as tissue messengers, Nature, 2020. ,
RIPK1 and NF-kappaB signaling in dying cells determines cross-priming of CD8(+) T cells, Science, vol.350, pp.328-334, 2015. ,
A small molecule Smac mimic potentiates TRAIL-and TNFalpha-mediated cell death, Science, vol.305, pp.1471-1474, 2004. ,
A. cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination, Mol. Cell, vol.30, pp.689-700, 2008. ,
URL : https://hal.archives-ouvertes.fr/halsde-00830439
Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer, J. Med. Chem, vol.47, pp.4417-4426, 2004. ,
IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis, Cell, vol.131, pp.669-681, 2007. ,
IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis, Cell, vol.131, pp.682-693, 2007. ,
TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced apoptosis, J. Biol. Chem, vol.284, pp.35906-35915, 2009. ,
TRAF2 Sets a threshold for extrinsic apoptosis by tagging caspase-8 with a ubiquitin shutoff timer, Mol. Cell, vol.48, pp.888-899, 2012. ,
TNF and NF-kappaB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1 ,
PD-L1 and IAPs co-operate to protect tumors from cytotoxic lymphocyte-derived TNF, Cell Death Differ, vol.24, pp.1705-1716, 2017. ,
, Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold. Cell, vol.178, pp.585-599, 2019.
Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis, Nat. Med, vol.5, pp.828-831, 1999. ,
Essential role of tumor necrosis factor alpha (TNF-alpha) in tumor promotion as revealed by TNF-alpha-deficient mice, Cancer Res, vol.59, pp.4516-4518, 1999. ,
NF-kappaB functions as a tumour promoter in inflammation-associated cancer, Nature, vol.431, pp.461-466, 2004. ,
Tumour necrosis factor and cancer, Nat. Rev. Cancer, vol.9, pp.361-371, 2009. ,
Oncogenic Ras diverts a host TNF tumor suppressor activity into tumor promoter, Dev. Cell, vol.18, pp.999-1011, 2010. ,
Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression, Cell, vol.140, pp.197-208, 2010. ,
Blocking Tumor Necrosis Factor alpha Enhances CD8 T-cell-Dependent Immunity in Experimental Melanoma, Cancer Res, vol.75, pp.2619-2628, 2015. ,
TNFalpha blockade overcomes resistance to anti-PD-1 in experimental melanoma, Nat. Commun, vol.8, 2017. ,
The TNF Paradox in Cancer Progression and Immunotherapy, Front. Immunol, vol.10, 1818. ,
Prophylactic TNF blockade uncouples efficacy and toxicity in dual CTLA-4 and PD-1 immunotherapy, Nature, vol.569, pp.428-432, 2019. ,
Lethal effect of the anti-Fas antibody in mice, Nature, vol.364, pp.806-809, 1993. ,
What's up in the ALPS, Curr. Opin. Immunol, vol.49, pp.79-86, 2017. ,
Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome, Cell, vol.81, pp.935-946, 1995. ,
Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity, Science, vol.268, pp.1347-1349, 1995. ,
Fas engagement induces neurite growth through ERK activation and p35 upregulation, Nat. Cell. Biol, vol.5, pp.118-125, 2003. ,
Functional significance of the Fas molecule in naive lymphocytes, Int. Immunol, vol.8, pp.423-431, 1996. ,
Complete loss of Fas ligand gene causes massive lymphoproliferation and early death, indicating a residual activity of gld allele, J. Immunol, vol.172, pp.2118-2125, 2004. ,
TRAIL and FasL Functions in Cancer and Autoimmune Diseases: Towards an Increasing Complexity, Cancers, vol.11, p.639, 2019. ,
URL : https://hal.archives-ouvertes.fr/hal-02189531
Cell cycle regulation by FasL and Apo2L/TRAIL in human T-cell blasts. Implications for autoimmune lymphoproliferative syndromes, J. Leukoc. Biol, vol.84, pp.488-498, 2008. ,
Memory T cell-driven differentiation of naive cells impairs adoptive immunotherapy, J. Clin. Investig, vol.126, pp.318-334, 2016. ,
The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis, Blood, vol.98, pp.194-200, 2001. ,
Loss of Fas/Apo-1 receptor accelerates lymphomagenesis in E mu L-MYC transgenic mice but not in animals infected with MoMuLV, Oncogene, vol.10, pp.2397-2401, 1995. ,
Fas ligand-mediated immune surveillance by T cells is essential for the control of spontaneous B cell lymphomas, Nat. Med, vol.20, pp.283-290, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-02386302
Fc gamma Rs modulate cytotoxicity of anti-Fas antibodies: Implications for agonistic antibody-based therapeutics, J. Immunol, vol.171, pp.562-568, 2003. ,
Two adjacent trimeric Fas ligands are required for Fas signaling and formation of a death-inducing signaling complex, Mol. Cell. Biol, vol.23, pp.1428-1440, 2003. ,
Combining radiotherapy with APO010 in cancer treatment, Clin. Cancer Res, vol.15, pp.2031-2038, 2009. ,
APO010, a synthetic hexameric CD95 ligand, induces human glioma cell death in vitro and in vivo, Neuro-Oncology, vol.13, pp.155-164, 2011. ,
, Nature, vol.465, pp.492-496, 2010.
The mechanism of how CD95/Fas activates the Type I IFN/STAT1 axis, driving cancer stemness in breast cancer, Sci. Rep, vol.10, 1310. ,
CD95/Fas Increases Stemness in Cancer Cells by Inducing a STAT1-Dependent Type I Interferon Response, vol.18, pp.2373-2386, 2017. ,
CD95 promotes metastatic spread via Sck in pancreatic ductal adenocarcinoma, Cell Death Differ, vol.22, pp.1192-1202, 2015. ,
CD95-ligand on peripheral myeloid cells activates Syk kinase to trigger their recruitment to the inflammatory site, Immunity, vol.32, pp.240-252, 2010. ,
Endothelial cell-derived CD95 ligand serves as a chemokine in induction of neutrophil slow rolling and adhesion, vol.5, 2016. ,
Fas/CD95-induced chemokines can serve as "find-me" signals for apoptotic cells, Mol. Cell, vol.49, pp.1034-1048, 2013. ,
Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors, Nat. Med, vol.20, pp.607-615, 2014. ,
Cancer-associated fibroblasts induce antigen-specific deletion of CD8 (+) T Cells to protect tumour cells, Nat. Commun, vol.9, p.948, 2018. ,
Van den Eynde, B.J. Resistance to cancer immunotherapy mediated by apoptosis of tumor-infiltrating lymphocytes, Nat. Commun, vol.8, 1404. ,
Oncogenic K-Ras turns death receptors into metastasis-promoting receptors in human and mouse colorectal cancer cells, Gastroenterology, vol.138, pp.2357-2367, 2010. ,
The death receptor CD95 activates the cofilin pathway to stimulate tumour cell invasion, EMBO Rep, vol.12, pp.931-937, 2011. ,
CD95 ligand induces senescence in mismatch repair-deficient human colon cancer via chronic caspase-mediated induction of DNA damage, Cell Death Dis, vol.8, 2017. ,
Yes and PI3K bind CD95 to signal invasion of glioblastoma, Cancer Cell, vol.13, pp.235-248, 2008. ,
A phase II, randomized, study of weekly APG101+reirradiation versus reirradiation in progressive glioblastoma, Clin. Cancer Res, vol.20, pp.6304-6313, 2014. ,
Inhibition of CD95/CD95L (FAS/FASLG) Signaling with APG101 Prevents Invasion and Enhances Radiation Therapy for Glioblastoma, Mol. Cancer Res, vol.16, pp.767-776, 2018. ,
Safety and efficacy of the CD95-ligand inhibitor asunercept in transfusion-dependent patients with low and intermediate risk MDS, Leuk. Res, vol.68, pp.62-69, 2018. ,
S-nitrosylation of the death receptor fas promotes fas ligand-mediated apoptosis in cancer cells, Gastroenterology, vol.140, 2009. ,
URL : https://hal.archives-ouvertes.fr/hal-00680824
Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations, Science, vol.288, pp.2354-2357, 2000. ,
Identification and characterization of a ligand-independent oligomerization domain in the extracellular region of the CD95 death receptor, J. Biol. Chem, vol.274, pp.38241-38250, 1999. ,
An Evolution-Guided Analysis Reveals a Multi-Signaling Regulation of Fas by Tyrosine Phosphorylation and its Implication in Human Cancers, PLoS Biol, vol.14, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01438523
, 3D Cellular Architecture Modulates Tyrosine Kinase Activity, Thereby Switching CD95-Mediated Apoptosis to Survival. Cell Rep, vol.29, pp.2295-2306, 2019.
Fas ligand in human serum, Nat. Med, vol.2, pp.317-322, 1996. ,
Downregulation of Fas ligand by shedding, Nat. Med, vol.4, pp.31-36, 1998. ,
Opposing effects of transmembrane and soluble Fas ligand expression on inflammation and tumor cell survival, J. Exp. Med, vol.191, pp.1209-1220, 2000. ,
Stromelysin-1 (MMP-3) in synovial fluid of patients with rheumatoid arthritis has potential to cleave membrane bound Fas ligand, J. Rheumatol, vol.28, pp.22-28, 2001. ,
Identification of novel matrix metalloproteinase-7 (matrilysin) cleavage sites in murine and human Fas ligand, Arch. Biochem. Biophys, vol.408, pp.155-161, 2002. ,
ADAM10 regulates FasL cell surface expression and modulates FasL-induced cytotoxicity and activation-induced cell death, Cell Death Differ, vol.14, pp.1040-1049, 2007. ,
The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells, Cell Death Differ, vol.14, pp.1678-1687, 2007. ,
URL : https://hal.archives-ouvertes.fr/hal-00318941
Matrix metalloproteinase-9 regulates TNF-alpha and FasL expression in neuronal, glial cells and its absence extends life in a transgenic mouse model of amyotrophic lateral sclerosis, Exp. Neurol, vol.205, pp.74-81, 2007. ,
Soluble Fas ligand in the joints of patients with rheumatoid arthritis and osteoarthritis, Arthritis Rheum, vol.41, pp.657-662, 1998. ,
Revised diagnostic criteria and classification for the autoimmune lymphoproliferative syndrome (ALPS): Report from the 2009 NIH International Workshop, Blood, vol.116, pp.35-40, 2010. ,
CD95-Mediated Calcium Signaling Promotes T Helper 17 Trafficking to Inflamed Organs in Lupus-Prone Mice, Immunity, vol.45, pp.209-223, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01359568
Conversion of membrane-bound Fas(CD95) ligand to its soluble form is associated with downregulation of its proapoptotic activity and loss of liver toxicity, J. Exp. Med, vol.187, pp.1205-1213, 1998. ,
Membrane Fas ligand kills human peripheral blood T lymphocytes, and soluble Fas ligand blocks the killing, J. Exp. Med, vol.186, pp.2045-2050, 1997. ,
Plasminogen activator inhibitor-1 protects endothelial cells from FasL-mediated apoptosis, Cancer Cell, vol.14, pp.324-334, 2008. ,
Dominant negative effects of tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 4 on TRAIL receptor 1 signaling by formation of heteromeric complexes, J. Biol. Chem, vol.289, pp.16576-16587, 2014. ,
Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2, Mol. Cell. Biol, vol.26, pp.7046-7055, 2006. ,
URL : https://hal.archives-ouvertes.fr/inserm-00103839
The tumor necrosis factor-related apoptosis-inducing ligand receptors TRAIL-R1 and TRAIL-R2 have distinct cross-linking requirements for initiation of apoptosis and are non-redundant in JNK activation, J. Biol. Chem, vol.275, pp.32208-32213, 2000. ,
TRAIL receptor gene editing unveils TRAIL-R1 as a master player of apoptosis induced by TRAIL and ER stress, Oncotarget, vol.8, pp.9974-9985, 2017. ,
URL : https://hal.archives-ouvertes.fr/inserm-01423110
Extreme lymphoproliferative disease and fatal autoimmune thrombocytopenia in FasL and TRAIL double-deficient mice, Blood, vol.115, pp.3258-3268, 2010. ,
Cutting edge: TRAIL deficiency accelerates hematological malignancies, J. Immunol, vol.175, pp.5586-5590, 2005. ,
TRAIL-R deficiency in mice promotes susceptibility to chronic inflammation and tumorigenesis, J. Clin. Investig, vol.118, pp.111-123, 2008. ,
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) contributes to interferon gamma-dependent natural killer cell protection from tumor metastasis, J. Exp. Med, vol.193, pp.661-670, 2001. ,
Involvement of tumor necrosis factor-related apoptosis-inducing ligand in NK cell-mediated and IFN-gamma-dependent suppression of subcutaneous tumor growth, Cell. Immunol, vol.214, pp.194-200, 2001. ,
Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo, Nat. Med, vol.5, pp.157-163, 1999. ,
Safety and antitumor activity of recombinant soluble Apo2 ligand, J. Clin. Investig, vol.104, pp.155-162, 1999. ,
Exploring the TRAILs less travelled: TRAIL in cancer biology and therapy, Nat. Rev. Cancer, 2017. ,
Molecular Mode of Action of TRAIL Receptor Agonists-Common Principles and Their Translational Exploitation. Cancers, vol.11, 2019. ,
Importance of TRAIL Molecular Anatomy in Receptor Oligomerization and Signaling. Implications for Cancer Therapy, Cancers, vol.11, 2019. ,
TRAILblazing Strategies for Cancer Treatment, Cancers, vol.11, 2019. ,
TRAIL-induced apoptosis and gene induction in HaCaT keratinocytes: Differential contribution of TRAIL receptors 1 and 2, J. Investig. Derm, vol.121, pp.149-155, 2003. ,
TRAIL receptor-selective mutants signal to apoptosis via TRAIL-R1 in primary lymphoid malignancies, Cancer Res, vol.65, pp.11265-11270, 2005. ,
TRAIL signaling is mediated by DR4 in pancreatic tumor cells despite the expression of functional DR5, J. Mol. Med, vol.88, pp.729-740, 2010. ,
TRAIL-induced apoptosis is preferentially mediated via TRAIL receptor 1 in pancreatic carcinoma cells and profoundly enhanced by XIAP inhibitors, Clin. Cancer Res, vol.16, pp.5734-5749, 2010. ,
Apo2L/TRAIL and the death receptor 5 agonist antibody AMG 655 cooperate to promote receptor clustering and antitumor activity, Cancer Cell, vol.26, pp.177-189, 2014. ,
TRAIL-R2-specific antibodies and recombinant TRAIL can synergise to kill cancer cells, Oncogene, vol.34, pp.2138-2144, 2015. ,
Selective Targeting of Myeloid-Derived Suppressor Cells in Cancer Patients Using DS-8273a, an Agonistic TRAIL-R2 Antibody, Clin. Cancer Res, vol.23, pp.2942-2950, 2017. ,
Proapoptotic activation of death receptor 5 on tumor endothelial cells disrupts the vasculature and reduces tumor growth, Cancer Cell, vol.22, pp.80-90, 2012. ,
TRAIL induced survival and proliferation in cancer cells resistant towards TRAIL-induced apoptosis mediated by NF-kappaB, Oncogene, vol.22, pp.3842-3852, 2003. ,
TRAIL promotes membrane blebbing, detachment and migration of cells displaying a dysfunctional intrinsic pathway of apoptosis, Apoptosis Int. J. Program. Cell Death, vol.18, pp.324-336, 2013. ,
TRAIL receptor mediates inflammatory cytokine release in an NF-kappaB-dependent manner, Cell Res, vol.19, pp.758-767, 2009. ,
The TRAIL-Induced Cancer Secretome Promotes a Tumor-Supportive Immune Microenvironment via CCR2, Mol. Cell, vol.65, pp.730-742, 2017. ,
TRAIL/NF-kappaB/CX3CL1 Mediated Onco-Immuno Crosstalk Leading to TRAIL Resistance of Pancreatic Cancer Cell Lines, Int. J. Mol. Sci, vol.19, p.1661, 2018. ,
The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death, EMBO J, 2017. ,
Caspase-8 Acts in a Non-enzymatic Role as a Scaffold for Assembly of a Pro-inflammatory "FADDosome" Complex upon TRAIL Stimulation, Mol. Cell, vol.65, pp.715-729, 2017. ,
Molecular determinants of kinase pathway activation by Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand, J. Biol. Chem, vol.280, pp.40599-40608, 2005. ,
The death domain kinase RIP is essential for TRAIL (Apo2L)-induced activation of IkappaB kinase and c-Jun N-terminal kinase, Mol. Cell. Biol, vol.20, pp.6638-6645, 2000. ,
Redundant and receptor-specific activities of TRADD, RIPK1 and FADD in death receptor signaling, Cell Death Dis, vol.10, 2019. ,
Kinome profiling of non-canonical TRAIL signaling reveals RIP1-Src-STAT3-dependent invasion in resistant non-small cell lung cancer cells, J. Cell Sci, vol.125, pp.4651-4661, 2012. ,
Nuclear death receptor TRAIL-R2 inhibits maturation of let-7 and promotes proliferation of pancreatic and other tumor cells, Gastroenterology, vol.146, pp.278-290, 2014. ,
Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor, EMBO J, vol.14, pp.5579-5588, 1995. ,
FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2, Immunity, vol.12, pp.599-609, 2000. ,
Stoichiometry of the CD95 death-inducing signaling complex: Experimental and modeling evidence for a death effector domain chain model, Mol. Cell, vol.47, pp.306-319, 2012. ,
A death effector domain chain DISC model reveals a crucial role for caspase-8 chain assembly in mediating apoptotic cell death, Mol. Cell, vol.47, pp.291-305, 2012. ,
Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex, Mol. Cell, vol.64, pp.236-250, 2016. ,
XIAP discriminates between type I and type II FAS-induced apoptosis, Nature, vol.460, pp.1035-1039, 2009. ,
Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate, Mol. Cell, vol.61, pp.834-849, 2016. ,
A revised model of TRAIL-R2 DISC assembly explains how FLIP(L) can inhibit or promote apoptosis ,
Long and short isoforms of c-FLIP act as control checkpoints of DED filament assembly, Oncogene, vol.39, pp.1756-1772, 2020. ,
Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling, Cell, vol.137, pp.721-735, 2009. ,
Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains, Nature, vol.501, pp.242-246, 2013. ,
A type III effector antagonizes death receptor signalling during bacterial gut infection, Nature, vol.501, pp.247-251, 2013. ,
The bacterial arginine glycosyltransferase effector NleB preferentially modifies Fas-associated death domain protein (FADD), J. Biol. Chem, vol.292, pp.17337-17350, 2017. ,
Mutant PIK3CA licenses TRAIL and CD95L to induce non-apoptotic caspase-8-mediated ROCK activation, Cell Death Differ, vol.17, pp.1435-1447, 2010. ,
, Nature, vol.508, pp.103-107, 2014.
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response, Nat. Cell. Biol, vol.2, pp.326-332, 2000. ,
ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals, Dev. Cell, vol.3, pp.99-111, 2002. ,
Unfolded proteins are Ire1-activating ligands that directly induce the unfolded protein response, Science, vol.333, pp.1891-1894, 2011. ,
An unfolded protein-induced conformational switch activates mammalian IRE1, vol.6, 2017. ,
The luminal domain of the ER stress sensor protein PERK binds misfolded proteins and thereby triggers PERK oligomerization, J. Biol. Chem, vol.293, pp.4110-4121, 2018. ,
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA, Nature, vol.415, pp.92-96, 2002. ,
Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1, Dev. Cell, vol.13, pp.365-376, 2007. ,
Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response, Science, vol.313, pp.104-107, 2006. ,
Getting RIDD of RNA: IRE1 in cell fate regulation, Trends Biochem. Sci, vol.39, pp.245-254, 2014. ,
IRE1alpha induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress, Cell Metab, vol.16, pp.250-264, 2012. ,
Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy, Nat. Commun, vol.9, p.3267, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-01879955
IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates, Cell, vol.138, pp.562-575, 2009. ,
The unfolded protein response signals through high-order assembly of Ire1, Nature, vol.457, pp.687-693, 2009. ,
Peptides derived from the bifunctional kinase/RNase enzyme IRE1alpha modulate IRE1alpha activity and protect cells from endoplasmic reticulum stress, FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol, vol.25, pp.3115-3129, 2011. ,
Allosteric inhibition of the IRE1alpha RNase preserves cell viability and function during endoplasmic reticulum stress, Cell, vol.158, pp.534-548, 2014. ,
Ire1 has distinct catalytic mechanisms for XBP1/HAC1 splicing and RIDD, Cell Rep, vol.9, pp.850-858, 2014. ,
A critical role of DDRGK1 in endoplasmic reticulum homoeostasis via regulation of IRE1alpha stability, Nat. Commun, vol.8, 2017. ,
The Unfolded Protein Response and Cell Fate Control, Mol. Cell, vol.69, pp.169-181, 2018. ,
Stress-induced tyrosine phosphorylation of RtcB modulates IRE1 activity and signaling outputs, vol.2020 ,
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1, Science, vol.287, pp.664-666, 2000. ,
Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression, Mol. Cell. Biol, vol.26, pp.3071-3084, 2006. ,
BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M, Mol. Cell. Biol, vol.19, pp.8469-8478, 1999. ,
Regulation of tumor-stroma interactions by the unfolded protein response, FEBS J, vol.286, pp.279-296, 2019. ,
URL : https://hal.archives-ouvertes.fr/hal-01808307
Reshaping the Immune Tumor Microenvironment Through IRE1 Signaling, Trends Mol. Med, vol.24, pp.607-614, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-01835398
Low-Protein Diet Induces IRE1alpha-Dependent Anticancer Immunosurveillance, Cell Metab, vol.27, pp.828-842, 2018. ,
Novel IRE1-dependent proinflammatory signaling controls tumor infiltration by myeloid cells, vol.2020 ,
IRE1alpha governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A, Nat. Cell. Biol, vol.20, pp.942-953, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-01879956
Non-canonical function of IRE1alpha determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics, Nat. Cell. Biol, vol.21, pp.755-767, 2019. ,
Imaging of single cell responses to ER stress indicates that the relative dynamics of IRE1/XBP1 and PERK/ATF4 signalling rather than a switch between signalling branches determine cell survival, Cell Death Differ, vol.22, pp.1502-1516, 2015. ,
Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum, J. Biol. Chem, vol.275, pp.24881-24885, 2000. ,
ATF4-Dependent NRF2 Transcriptional Regulation Promotes Antioxidant Protection during Endoplasmic Reticulum Stress, Cancers, vol.12, 2020. ,
URL : https://hal.archives-ouvertes.fr/hal-02534425
Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival, Mol. Cell. Biol, vol.23, pp.7198-7209, 2003. ,
PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress, J. Biol. Chem, vol.279, 2004. ,
ER stress activates NF-kappaB by integrating functions of basal IKK activity, IRE1 and PERK, PLoS ONE, vol.7, 2012. ,
ER stress triggers apoptosis by activating BH3-only protein Bim, Cell, vol.129, pp.1337-1349, 2007. ,
Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state, Mol. Cell. Biol, vol.21, pp.1249-1259, 2001. ,
Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway, Nature, 2020. ,
A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol, Nature, 2020. ,
Integrated stress response of vertebrates is regulated by four eIF2alpha kinases, Sci. Rep, vol.6, 2016. ,
Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1, Mol. Cell. Biol, vol.21, pp.6841-6850, 2001. ,
Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha, J. Cell Biol, vol.153, pp.1011-1022, 2001. ,
CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum, Genes Dev, vol.18, pp.3066-3077, 2004. ,
Epithelial-to-mesenchymal transition activates PERK-eIF2alpha and sensitizes cells to endoplasmic reticulum stress, Cancer Discov, vol.4, pp.702-715, 2014. ,
Unresolved endoplasmic reticulum stress engenders immune-resistant, latent pancreatic cancer metastases, Science, vol.360, 2018. ,
Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress, Mol. Biol. Cell, vol.10, pp.3787-3799, 1999. ,
ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs, Mol. Cell, vol.6, pp.1355-1364, 2000. ,
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor, Cell, vol.107, pp.881-891, 2001. ,
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response, Genes Dev, vol.16, pp.452-466, 2002. ,
Cell death induced by endoplasmic reticulum stress, FEBS J, vol.283, pp.2640-2652, 2016. ,
DDIT3 and KAT2A Proteins Regulate TNFRSF10A and TNFRSF10B Expression in Endoplasmic Reticulum Stress-mediated Apoptosis in Human Lung Cancer Cells, J. Biol. Chem, vol.290, pp.11108-11118, 2015. ,
Golgi stress response and organelle zones, FEBS Lett, vol.593, pp.2330-2340, 2019. ,
Endoplasmic reticulum calcium pool depletion-induced apoptosis is coupled with activation of the death receptor 5 pathway, Oncogene, vol.21, pp.2623-2633, 2002. ,
CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells, J. Biol. Chem, vol.279, pp.45495-45502, 2004. ,
Death receptor 5 signaling promotes hepatocyte lipoapoptosis, J. Biol. Chem, vol.286, pp.39336-39348, 2011. ,
Confirming a critical role for death receptor 5 and caspase-8 in apoptosis induction by endoplasmic reticulum stress, Cell Death Differ, vol.25, pp.1530-1531, 2018. ,
Secretory stressors induce intracellular death receptor accumulation to control apoptosis ,
Tunicamycin sensitizes human melanoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by up-regulation of TRAIL-R2 via the unfolded protein response, Cancer Res, vol.67, pp.5880-5888, 2007. ,
Glucose Deprivation Induces ATF4-Mediated Apoptosis through TRAIL Death Receptors, Mol. Cell. Biol, vol.37, 2017. ,
Bax plays a pivotal role in thapsigargin-induced apoptosis of human colon cancer HCT116 cells by controlling Smac/Diablo and Omi/HtrA2 release from mitochondria, Cancer Res, vol.63, pp.1483-1489, 2003. ,
Involvement of both caspase-8 and Noxa-activated pathways in endoplasmic reticulum stress-induced apoptosis in triple-negative breast tumor cells, Cell Death Dis, vol.9, p.134, 2018. ,
Higher-Order Clustering of the Transmembrane Anchor of DR5 Drives Signaling, Cell, vol.176, pp.1477-1489, 2019. ,
Disulfide bond-disrupting agents activate the tumor necrosis family-related apoptosis-inducing ligand/death receptor 5 pathway, Cell Death Discov, vol.5, 2019. ,
Misfolded proteins bind and activate death receptor 5 to induce apoptosis during unresolved endoplasmic reticulum stress, Elife, vol.2020 ,
Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis, Proc. Natl. Acad. Sci, vol.102, pp.18099-18104, 2005. ,
Hetero-oligomerization between the TNF receptor superfamily members CD40, Fas and TRAILR2 modulate CD40 signalling, Cell Death Dis, 2017. ,
Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis, Science, vol.345, pp.98-101, 2014. ,
IRE1 signaling affects cell fate during the unfolded protein response, Science, vol.318, pp.944-949, 2007. ,
Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate, Mol. Cell, vol.71, pp.629-636, 2018. ,
TRAIL Receptors Serve as Stress-Associated Molecular Patterns to Promote ER-Stress-Induced Inflammation, Dev. Cell, vol.52, 2020. ,
Starvation and antimetabolic therapy promote cytokine release and recruitment of immune cells, Proc. Natl. Acad. Sci. USA 2020 ,
Inhibition of eIF2alpha dephosphorylation enhances TRAIL-induced apoptosis in hepatoma cells, Cell Death Dis, vol.5, 1060. ,
Thapsigargin sensitizes human melanoma cells to TRAIL-induced apoptosis by up-regulation of TRAIL-R2 through the unfolded protein response, Carcinogenesis, vol.28, pp.2328-2336, 2007. ,
Tunicamycin enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human prostate cancer cells, Cancer Res, vol.65, pp.6364-6370, 2005. ,
N-glycosylation of mouse TRAIL-R restrains TRAIL-induced apoptosis, Cell Death Dis, vol.9, 2018. ,
N-glycosylation of mouse TRAIL-R and human TRAIL-R1 enhances TRAIL-induced death, Cell Death Differ, vol.24, pp.500-510, 2017. ,
URL : https://hal.archives-ouvertes.fr/inserm-01467849
ER stress sensitizes cells to TRAIL through down-regulation of FLIP and Mcl-1 and PERK-dependent up-regulation of TRAIL-R2, Apoptosis Int. J. Program. Cell Death, vol.17, pp.349-363, 2012. ,
Nelfinavir and other protease inhibitors in cancer: Mechanisms involved in anticancer activity, 1000. ,
An inhibitor of HIV-1 protease modulates constitutive eIF2alpha dephosphorylation to trigger a specific integrated stress response, Proc. Natl. Acad. Sci, vol.113, pp.117-126, 2016. ,
Modulation of CCAAT/enhancer binding protein homologous protein (CHOP)-dependent DR5 expression by nelfinavir sensitizes glioblastoma multiforme cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), J. Biol. Chem, vol.286, pp.29408-29416, 2011. ,
IRE1alpha-XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity, Nature, vol.562, pp.423-428, 2018. ,
The IRE1 endoplasmic reticulum stress sensor activates natural killer cell immunity in part by regulating c-Myc, Nat. Immunol, vol.20, pp.865-878, 2019. ,
ER stress regulates myeloid-derived suppressor cell fate through TRAIL-R-mediated apoptosis, J. Clin. Investig, vol.124, pp.2626-2639, 2014. ,
Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways, J. Clin. Investig, vol.119, pp.2925-2941, 2009. ,
TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages, Nat. Immunol, vol.11, pp.411-418, 2010. ,
Tumour necrosis factor receptor 1 mediates endoplasmic reticulum stress-induced activation of the MAP kinase JNK, EMBO Rep, vol.7, pp.622-627, 2006. ,
RIPK1 promotes death receptor-independent caspase-8-mediated apoptosis under unresolved ER stress conditions, Cell Death Dis, vol.5, 1555. ,
Endoplasmic reticulum stress induces ligand-independent TNFR1-mediated necroptosis in L929 cells, Cell Death Dis, vol.6, 1587. ,
Inflammation Improves Glucose Homeostasis through IKKbeta-XBP1s Interaction, Cell, vol.167, pp.1052-1066, 2016. ,
Tumor necrosis factor receptor I from patients with tumor necrosis factor receptor-associated periodic syndrome interacts with wild-type tumor necrosis factor receptor I and induces ligand-independent NF-kappaB activation, Arthritis Rheum, vol.52, pp.2906-2916, 2005. ,
Abnormal disulfide-linked oligomerization results in ER retention and altered signaling by TNFR1 mutants in TNFR1-associated periodic fever syndrome (TRAPS), Blood, vol.108, pp.1320-1327, 2006. ,
The novel S59P mutation in the TNFRSF1A gene identified in an adult onset TNF receptor associated periodic syndrome (TRAPS) constitutively activates NF-?B pathway, Arthritis Res. Ther, vol.17, p.93, 2015. ,
Repression of GADD153/CHOP by NF-kappaB: A possible cellular defense against endoplasmic reticulum stress-induced cell death, Oncogene, vol.20, pp.2178-2185, 2001. ,
Translational induction of the inhibitor of apoptosis protein HIAP2 during endoplasmic reticulum stress attenuates cell death and is mediated via an inducible internal ribosome entry site element, J. Biol. Chem, vol.279, pp.17148-17157, 2004. ,
PERK-dependent regulation of IAP translation during ER stress, Oncogene, vol.28, pp.910-920, 2009. ,
Critical role of endogenous Akt/IAPs and MEK1/ERK pathways in counteracting endoplasmic reticulum stress-induced cell death, J. Biol. Chem, vol.279, pp.49420-49429, 2004. ,
Smac mimetic suppresses tunicamycin-induced apoptosis via resolution of ER stress, Cell Death Dis, vol.10, 2019. ,
Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha, Science, vol.312, pp.572-576, 2006. ,
Caspase-mediated cleavage of IRE1 controls apoptotic cell commitment during endoplasmic reticulum stress, vol.8, 2019. ,
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