, Supplementary Materials: Supplementary materials can be
The European IPF registry (eurIPFreg): Baseline characteristics and survival of patients with idiopathic pulmonary fibrosis, Respir. Res, vol.19, p.141, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-02006205
ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the, ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT), vol.46, pp.903-975, 2015. ,
Genetic studies provide clues on the pathogenesis of idiopathic pulmonary fibrosis, Dis. Model. Mech, vol.6, pp.9-17, 2013. ,
Analysis of macrophage migration inhibitory factor (MIF) in patients with idiopathic pulmonary fibrosis, Respir. Physiol. Neurobiol, vol.167, pp.261-267, 2009. ,
Macrophage migration inhibitory factor in lung tissue of idiopathic pulmonary fibrosis patients, Exp. Lung Res, vol.42, pp.263-266, 2016. ,
Role of macrophage migration inhibitory factor in bleomycin-induced lung injury and fibrosis in mice, Am. J. Physiol. Lung Cell. Mol. Physiol, vol.283, pp.156-162, 2002. ,
Serum levels, tissue expression and cellular secretion of macrophage migration inhibitory factor in limited and diffuse systemic sclerosis, Clin. Exp. Rheumatol, vol.33, pp.98-105, 2015. ,
Synthesis, and Biological Activity of New N-(Phenylmethyl)-benzoxazol-2-thiones as Macrophage Migration Inhibitory Factor (MIF) Antagonists: Efficacies in Experimental Pulmonary Hypertension, J. Med. Chem, vol.61, pp.2725-2736, 2018. ,
URL : https://hal.archives-ouvertes.fr/inserm-02580381
Proinflammatory Signature of the Dysfunctional Endothelium in Pulmonary Hypertension. Role of the Macrophage Migration Inhibitory Factor/CD74 Complex, Am. J. Respir. Crit. Care Med, vol.192, pp.983-997, 2015. ,
URL : https://hal.archives-ouvertes.fr/inserm-02579320
Optimising experimental research in respiratory diseases: An ERS statement, Eur. Respir. J, vol.51, p.1702133, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-01996906
The bleomycin animal model: A useful tool to investigate treatment options for idiopathic pulmonary fibrosis?, Int. J. Biochem. Cell. Biol, vol.40, pp.362-382, 2008. ,
Bleomycin-induced chronic lung damage does not resemble human idiopathic pulmonary fibrosis, Am. J. Respir. Crit. Care Med, vol.163, pp.1648-1653, 2001. ,
Antifibrotic activities of pirfenidone in animal models, Eur. Respir. Rev, vol.20, pp.85-97, 2011. ,
Antifibrotic and anti-inflammatory activity of the tyrosine kinase inhibitor nintedanib in experimental models of lung fibrosis, J. Pharmacol. Exp. Ther, vol.349, pp.209-220, 2014. ,
VEGF ameliorates pulmonary hypertension through inhibition of endothelial apoptosis in experimental lung fibrosis in rats, J. Clin. Investig, vol.119, pp.1298-1311, 2009. ,
Role of macrophage migration inhibitory factor in the proliferation of smooth muscle cell in pulmonary hypertension, Mediators Inflamm, vol.840737, 2012. ,
Macrophage migration inhibitory factor mediates hypoxia-induced pulmonary hypertension, Mol. Med, vol.18, pp.215-223, 2012. ,
Time course of bleomycin-induced lung fibrosis, Int. J. Exp. Pathol, vol.83, pp.111-119, 2002. ,
Monocyte chemoattractant protein-1 (MCP-1): An overview, J. Interferon Cytokine Res, vol.29, pp.313-326, 2009. ,
Pulmonary vascular lesions in end-stage idiopathic pulmonary fibrosis: Histopathologic study on lung explant specimens and correlations with pulmonary hemodynamics, Hum. Pathol, vol.38, pp.60-65, 2007. ,
Role of MIF and D-DT in immune-inflammatory, autoimmune, and chronic respiratory diseases: From pathogenic factors to therapeutic targets, Drug Discov. Today, 2018. ,
Elevated serum macrophage migration inhibitory factor (MIF) concentrations in chronic kidney disease (CKD) are associated with markers of oxidative stress and endothelial activation, Mol. Med, vol.15, pp.70-75, 2009. ,
Inhibition of Macrophage Migration Inhibitory Factor Protects against Inflammation and Matrix Deposition in Kidney Tissues after Injury, Mediators Inflamm, 2016. ,
The role of macrophage migration inhibitory factor in mast cell-stimulated fibroblast proliferation and collagen production, PLoS ONE, vol.10, 2015. ,
An MIF Promoter Polymorphism Is Associated with Susceptibility to Pulmonary Arterial Hypertension in Diffuse Cutaneous Systemic Sclerosis, J. Rheumatol, vol.44, pp.1453-1457, 2017. ,
MIF, a controversial cytokine: A review of structural features, challenges, and opportunities for drug development, Expert Opin. Ther. Targets, vol.20, pp.1463-1475, 2016. ,
An Analysis of MIF Structural Features that Control Functional Activation of CD74, Chem. Biol, vol.22, pp.1197-1205, 2015. ,
Macrophage Migration Inhibitory Factor-CXCR4 Receptor Interactions: Evidence for Partial Allosteric Agonism in Comparison with CXCL12 Chemokine, J. Biol. Chem, vol.291, pp.15881-15895, 2016. ,
MIF as a disease target: ISO-1 as a proof-of-concept therapeutic, Future Med. Chem, vol.3, pp.45-63, 2011. ,
Irregularities in enzyme assays: The case of macrophage migration inhibitory factor, Bioorg. Med. Chem. Lett, vol.26, pp.2764-2767, 2016. ,
Advances and Insights for Small Molecule Inhibition of Macrophage Migration Inhibitory Factor, J. Med. Chem, 2018. ,
Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1, Nature, vol.408, pp.211-216, 2000. ,
Diagnosis of Idiopathic Pulmonary Fibrosis. An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline, Am. J. Respir. Crit. Care Med, vol.198, pp.44-68, 2018. ,
Dasatinib induces lung vascular toxicity and predisposes to pulmonary hypertension, J. Clin. Investig, vol.126, pp.3207-3218, 2016. ,
URL : https://hal.archives-ouvertes.fr/inserm-02579754
Leptin signalling system as a target for pulmonary arterial hypertension therapy, Eur. Respir. J, vol.45, pp.1066-1080, 2015. ,
URL : https://hal.archives-ouvertes.fr/inserm-02579431
Vonk Noordegraaf, A.; et al. Dasatinib increases endothelial permeability leading to pleural effusion, Eur. Respir. J, vol.51, 2018. ,
Ectopic upregulation of membrane-bound IL6R drives vascular remodeling in pulmonary arterial hypertension, J. Clin. Investig, vol.128, 1956. ,
URL : https://hal.archives-ouvertes.fr/inserm-02580448
A critical role for p130Cas in the progression of pulmonary hypertension in humans and rodents, Am. J. Respir. Crit. Care Med, vol.186, pp.666-676, 2012. ,
URL : https://hal.archives-ouvertes.fr/inserm-00905191
A robust collagen scoring method for human liver fibrosis by second harmonic microscopy, Opt. Express, vol.18, pp.25794-25807, 2010. ,
URL : https://hal.archives-ouvertes.fr/hal-00684532
Dysregulated renin-angiotensin-aldosterone system contributes to pulmonary arterial hypertension, Am. J. Respir. Crit. Care Med, vol.186, pp.780-789, 2012. ,
URL : https://hal.archives-ouvertes.fr/inserm-00905193
Autocrine fibroblast growth factor-2 signaling contributes to altered endothelial phenotype in pulmonary hypertension, Am. J. Respir. Cell. Mol. Biol, vol.45, pp.311-322, 2011. ,
URL : https://hal.archives-ouvertes.fr/inserm-00579959