The NMDA receptor regulates competition of epithelial cells in the Drosophila wing - Archive ouverte HAL Access content directly
Journal Articles Nature Communications Year : 2020

The NMDA receptor regulates competition of epithelial cells in the Drosophila wing

(1, 2) , (1)
1
2

Abstract

Cell competition is an emerging principle that eliminates suboptimal or potentially dangerous cells. For 'unfit' cells to be detected, their competitive status needs to be compared to the collective fitness of cells within a tissue. Here we report that the NMDA receptor controls cell competition of epithelial cells and Myc supercompetitors in the Drosophila wing disc. While clonal depletion of the NMDA receptor subunit NR2 results in their rapid elimination via the TNF/Eiger>JNK signalling pathway, local over-expression of NR2 causes NR2 cells to acquire supercompetitor-like behaviour that enables them to overtake the tissue through clonal expansion that causes, but also relies on, the killing of surrounding cells. Consistently, NR2 is utilised by Myc clones to provide them with supercompetitor status. Mechanistically, we find that the JNK>PDK signalling axis in 'loser' cells reprograms their metabolism, driving them to produce and transfer lactate to winners. Preventing lactate transfer from losers to winners abrogates NMDAR-mediated cell competition. Our findings demonstrate a functional repurposing of NMDAR in the surveillance of tissue fitness.
Fichier principal
Vignette du fichier
s41467-020-16070-6.pdf (8.45 Mo) Télécharger le fichier
Origin : Publication funded by an institution
Loading...

Dates and versions

inserm-02592237 , version 1 (15-05-2020)

Identifiers

Cite

Agnes R Banreti, Pascal Meier. The NMDA receptor regulates competition of epithelial cells in the Drosophila wing. Nature Communications, 2020, 11 (1), pp.2228. ⟨10.1038/s41467-020-16070-6⟩. ⟨inserm-02592237⟩
36 View
30 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More