Adenosine receptors as drug targets for treatment of pulmonary arterial hypertension, Front. Pharmacol, vol.8, p.858, 2017. ,
Basic science of pulmonary arterial hypertension for clinicians: new concepts and experimental therapies, Circulation, vol.121, pp.2045-2066, 2010. ,
Pan-PPAR agonist IVA337 is effective in experimental lung fibrosis and pulmonary hypertension, Ann. Rheum. Dis, vol.76, 1931. ,
Pulmonary hypertension in interstitial lung disease, Eur. Respir. J, vol.31, pp.1357-1367, 2008. ,
Long-term treatment with fasudil improves bleomycininduced pulmonary fibrosis and pulmonary hypertension via inhibition of Smad2/3 phosphorylation, Pulm. Pharmacol. Ther, vol.26, pp.635-643, 2013. ,
Too much of a good thing: adenosine overload in adenosine-deaminase-deficient mice, Trends Pharmacol. Sci, vol.24, pp.66-70, 2003. ,
Adenosine deaminase deficiency: metabolic basis of immune deficiency and pulmonary inflammation, Adv. Immunol, vol.86, pp.1-41, 2005. ,
Macrophage bone morphogenic protein receptor 2 depletion in idiopathic pulmonary fibrosis and Group III pulmonary hypertension, Am. J. Physiol. Lung Cell. Mol. Physiol, vol.311, pp.238-254, 2016. ,
Partially adenosine deaminase-deficient mice develop pulmonary fibrosis in association with adenosine elevations, Am. J. Physiol. Lung Cell. Mol. Physiol, vol.290, pp.579-587, 2006. ,
A novel murine model of severe pulmonary arterial hypertension, Am. J. Respir. Crit. Care Med, vol.184, pp.1171-1182, 2011. ,
Physiological roles for ecto-5 ? -nucleotidase (CD73), Purinergic Signal, vol.2, pp.351-360, 2006. ,
Pulmonary hypertension associated with idiopathic pulmonary fibrosis: current and future perspectives, Can. Respir. J, p.1430350, 2017. ,
Inhibition of hyaluronan synthesis attenuates pulmonary hypertension associated with lung fibrosis, Br. J. Pharmacol, vol.174, pp.3284-3301, 2017. ,
Adenosine promotes vascular barrier function in hyperoxic lung injury, Physiol Rep, vol.2, p.12155, 2014. ,
Elevated transglutaminase 2 activity is associated with hypoxiainduced experimental pulmonary hypertension in mice, ACS Chem. Biol, vol.9, pp.266-275, 2014. ,
Transglutaminase regulation of cell function, Physiol. Rev, vol.94, pp.383-417, 2014. ,
Identification of ectonucleotidases CD39 and CD73 in innate protection during acute lung injury, J. Immunol, vol.178, pp.8127-8137, 2007. ,
Role of extracellular adenosine in acute lung injury, Physiology, vol.24, pp.298-306, 2009. ,
HIF-1-dependent repression of equilibrative nucleoside transporter (ENT) in hypoxia, J. Exp. Med, vol.202, pp.1493-1505, 2005. ,
Pulmonary hypertension and idiopathic pulmonary fibrosis: a tale of angiogenesis, apoptosis, and growth factors, Am. J. Respir. Cell Mol. Biol, vol.45, pp.1-15, 2011. ,
Idiopathic pulmonary fibrosis: phenotypes and comorbidities, Clin. Chest Med, vol.33, pp.51-57, 2012. ,
Purinergic signaling in scarring, FASEB J, vol.30, pp.3-12, 2016. ,
Adenosine, an endogenous distress signal, modulates tissue damage and repair, Cell Death Differ, vol.14, pp.1315-1323, 2007. ,
International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors, Pharmacol. Rev, vol.53, pp.527-552, 2001. ,
Altered hypoxic-adenosine axis and metabolism in group III pulmonary hypertension, Am. J. Respir. Cell Mol. Biol, vol.54, pp.574-583, 2016. ,
Arginase inhibition prevents bleomycin-induced pulmonary hypertension, vascular remodeling, and collagen deposition in neonatal rat lungs, Am. J. Physiol. Lung Cell. Mol. Physiol, vol.308, 2015. ,
Serotonin transporter inhibition prevents and reverses monocrotaline-induced pulmonary hypertension in rats, Circulation, vol.111, pp.2812-2819, 2005. ,
URL : https://hal.archives-ouvertes.fr/inserm-00499643
Transglutaminase 2: a molecular Swiss army knife, Biochim. Biophys. Acta, vol.1823, pp.406-419, 2012. ,
WHO's in second?: A practical review of World Health Organization group 2 pulmonary hypertension, Chest, vol.144, pp.638-650, 2013. ,
SP1-dependent induction of CD39 facilitates hepatic ischemic preconditioning, J. Immunol, vol.184, pp.4017-4024, 2010. ,
PDE5A inhibition attenuates bleomycin-induced pulmonary fibrosis and pulmonary hypertension through inhibition of ROS generation and RhoA/Rho kinase activation, Am. J. Physiol. Lung Cell. Mol. Physiol, vol.294, pp.24-33, 2008. ,
Standardized quantification of pulmonary fibrosis in histological samples, Biotechniques, vol.44, pp.514-507, 2008. ,
Leptin signalling system as a target for pulmonary arterial hypertension therapy, Eur. Respir. J, vol.45, pp.1066-1080, 2015. ,
URL : https://hal.archives-ouvertes.fr/inserm-02578446
Acute exacerbations and pulmonary hypertension in advanced idiopathic pulmonary fibrosis, Eur. Respir. J, vol.40, pp.93-100, 2012. ,
Deletion of ADORA2B from myeloid cells dampens lung fibrosis and pulmonary hypertension, FASEB J, vol.29, pp.50-60, 2015. ,
ADORA2B and hyaluronan modulate pulmonary hypertension associated with chronic obstructive pulmonary disease, Am. J. Respir. Cell Mol. Biol, vol.49, pp.1038-1047, 2013. ,
, , 2013.
, Adenosine signaling during acute and chronic disease states, J. Mol. Med, vol.91, pp.173-181
The A2B adenosine receptor modulates pulmonary hypertension associated with interstitial lung disease, FASEB J, vol.26, pp.2546-2557, 2012. ,
Dipyridamole inhibition of adenosine metabolism in human blood, Eur. J. Pharmacol, vol.93, pp.21-26, 1983. ,
Group III pulmonary hypertension: pulmonary hypertension associated with lung disease: epidemiology, pathophysiology, and treatments, Cardiol. Clin, vol.34, pp.413-433, 2016. ,
Isolation of pulmonary artery smooth muscle cells from neonatal mice, J. Vis. Exp. e50889, 2013. ,
Neutrophilderived 5'-adenosine monophosphate promotes endothelial barrier function via CD73-mediated conversion to adenosine and endothelial A2B receptor activation, J. Exp. Med, vol.188, pp.1433-1443, 1998. ,
Inflammation, autoimmunity, and hypertension: the essential role of tissue transglutaminase, Am. J. Hypertens, vol.30, pp.756-764, 2017. ,
Elevated transglutaminase activity triggers angiotensin receptor activating autoantibody production and pathophysiology of Preeclampsia, J Am Heart Assoc, vol.4, p.2323, 2015. ,
Tissue transglutaminase contributes to the pathogenesis of preeclampsia and stabilizes placental angiotensin receptor type 1 by ubiquitination-preventing isopeptide modification, Hypertension, vol.63, pp.353-361, 2014. ,
Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins, Circulation, vol.104, pp.790-795, 2001. ,
Epithelial transglutaminase 2 is needed for T cell interleukin-17 production and subsequent pulmonary inflammation and fibrosis in bleomycin-treated mice, J. Exp. Med, vol.208, pp.1707-1719, 2011. ,
Inhibition of transglutaminase 2, a novel target for pulmonary fibrosis, by two small electrophilic molecules, Am. J. Respir. Cell Mol. Biol, vol.50, pp.737-747, 2014. ,
Transglutaminase 2 and its role in pulmonary fibrosis, Am. J. Respir. Crit. Care Med, vol.184, pp.699-707, 2011. ,
Interleukin-6 contributes to inflammation and remodeling in a model of adenosine mediated lung injury, PLoS ONE, vol.6, p.22667, 2011. ,
Role of hypoxia-induced transglutaminase 2 in pulmonary artery smooth muscle cell proliferation, Am. J. Physiol. Lung Cell. Mol. Physiol, vol.307, pp.576-585, 2014. ,
Transglutaminase 2 in pulmonary and cardiac tissue remodeling in experimental pulmonary hypertension, Am. J. Physiol. Lung Cell. Mol. Physiol, vol.313, pp.752-762, 2017. ,
Pulmonary hypertension in idiopathic pulmonary fibrosis: a review, Respiration, vol.82, pp.294-304, 2011. ,
World Health Organization Group III pulmonary hypertension, Prog. Cardiovasc. Dis, vol.55, pp.119-127, 2012. ,
Increased pericyte coverage mediated by endothelial-derived fibroblast growth factor-2 and interleukin-6 is a source of smooth muscle-like cells in pulmonary hypertension, Circulation, vol.129, pp.1586-1597, 2014. ,
URL : https://hal.archives-ouvertes.fr/inserm-02578269
Pulmonary hypertension in parenchymal lung disease, Heart Fail. Clin, vol.8, pp.461-474, 2012. ,
Adenosine plasma concentration in pulmonary hypertension, Cardiovasc. Res, vol.43, pp.228-236, 1999. ,
Improvement of bleomycin-induced pulmonary hypertension and pulmonary fibrosis by the endothelin receptor antagonist Bosentan, Respir. Physiol. Neurobiol, vol.170, pp.32-36, 2010. ,
Effects of simvastatin on pulmonary fibrosis, pulmonary hypertension and exercise capacity in bleomycin-treated rats, Acta Physiol, vol.208, pp.191-201, 2013. ,
Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent, Nat. Commun, vol.8, p.14108, 2017. ,
Role of A2B adenosine receptor signaling in adenosine-dependent pulmonary inflammation and injury, J. Clin. Invest, vol.116, pp.2173-2182, 2006. ,
Erythrocyte purinergic signaling components underlie hypoxia adaptation, J. Appl. Physiol, vol.123, pp.951-956, 2017. ,
Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia, J. Clin. Invest, vol.110, pp.993-1002, 2002. ,
GS-6201, a selective blocker of the A2B adenosine receptor, attenuates cardiac remodeling after acute myocardial infarction in the mouse, J. Pharmacol. Exp. Ther, vol.343, pp.587-595, 2012. ,
Role of pulmonary adenosine during hypoxia: extracellular generation, signaling and metabolism by surface adenosine deaminase/CD26. Expert Opin, Biol. Ther, vol.7, pp.1437-1447, 2007. ,
Lung extracellular superoxide dismutase overexpression lessens bleomycin-induced pulmonary hypertension and vascular remodeling, Am. J. Respir. Cell Mol. Biol, vol.44, pp.500-508, 2011. ,
WHO Group 1 pulmonary arterial hypertension: current and investigative therapies, Prog. Cardiovasc. Dis, vol.55, pp.89-103, 2012. ,
Ecto-5 ? -nucleotidase (CD73)-mediated adenosine production is tissue protective in a model of bleomycin-induced lung injury, J. Immunol, vol.176, pp.4449-4458, 2006. ,
Disruption of the adenosine-deaminase gene causes hepatocellular impairment and perinatal lethality in mice, Proc. Natl. Acad. Sci. U.S.A, vol.92, pp.3673-3677, 1995. ,
Extracellular adenosine production by ecto-5 ? -nucleotidase (CD73) enhances radiation-induced lung fibrosis, Cancer Res, vol.76, pp.3045-3056, 2016. ,
Alterations in adenosine metabolism and signaling in patients with chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis, PLoS ONE, vol.5, p.9224, 2010. ,
, , 2009.
, Adenosine signaling and the regulation of chronic lung disease, Pharmacol. Ther, vol.123, pp.105-116
Signaling through hepatocellular A2B adenosine receptors dampens ischemia and reperfusion injury of the liver, Proc. Natl. Acad. Sci. U.S.A, vol.110, pp.12012-12017, 2013. ,
, Conflict of Interest Statement: The authors declare that the research was
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