Dasatinib induces lung vascular toxicity and predisposes to pulmonary hypertension

Christophe Guignabert; Carole Phan; Andrei Seferian; Alice Huertas; Ly Tu; Raphaël Thuillet; Caroline Sattler; Morane Le Hiress; Yuichi Tamura; Etienne-Marie Jutant; Marie-Camille Chaumais; Stéphane Bouchet; Benjamin Maneglier; Mathieu Molimard; Philippe Rousselot; Olivier Sitbon; Gerald Simonneau; David Montani; Marc Humbert

doi:10.1172/JCI86249

Journal Articles Journal of Clinical Investigation Year : 2016

Dasatinib induces lung vascular toxicity and predisposes to pulmonary hypertension

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Christophe Guignabert

Function : Author
PersonId : 184750
IdHAL : christophe-guignabert
ORCID : 0000-0002-8545-4452
IdRef : 095316213

INSERM UMR_S 999, Hôpital Marie Lannelongue, Le Plessis-Robinson, France

Université Paris-Saclay, School of Medicine, Le Kremlin-Bicêtre, France

AP-HP, Department of Respiratory and Intensive Care Medicine, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.

CV

Carole Phan

Function : Author
PersonId : 184774
IdHAL : carole-phan
ORCID : 0000-0002-7834-508X
IdRef : 231213034

INSERM UMR_S 999, Hôpital Marie Lannelongue, Le Plessis-Robinson, France

Université Paris-Saclay, School of Medicine, Le Kremlin-Bicêtre, France

AP-HP, Department of Respiratory and Intensive Care Medicine, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.

Andrei Seferian

Function : Author
PersonId : 907257

INSERM UMR_S 999, Hôpital Marie Lannelongue, Le Plessis-Robinson, France

Université Paris-Saclay, School of Medicine, Le Kremlin-Bicêtre, France

AP-HP, Department of Respiratory and Intensive Care Medicine, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.

Alice Huertas

Function : Author

INSERM UMR_S 999, Hôpital Marie Lannelongue, Le Plessis-Robinson, France

Université Paris-Saclay, School of Medicine, Le Kremlin-Bicêtre, France

AP-HP, Department of Respiratory and Intensive Care Medicine, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.

Ly Tu

Function : Author
PersonId : 761927
ORCID : 0000-0003-2336-5099
IdRef : 162030649

INSERM UMR_S 999, Hôpital Marie Lannelongue, Le Plessis-Robinson, France

Université Paris-Saclay, School of Medicine, Le Kremlin-Bicêtre, France

AP-HP, Department of Respiratory and Intensive Care Medicine, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.

Raphaël Thuillet

Function : Author

INSERM UMR_S 999, Hôpital Marie Lannelongue, Le Plessis-Robinson, France

Université Paris-Saclay, School of Medicine, Le Kremlin-Bicêtre, France

AP-HP, Department of Respiratory and Intensive Care Medicine, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.

Caroline Sattler

Function : Author

INSERM UMR_S 999, Hôpital Marie Lannelongue, Le Plessis-Robinson, France

Université Paris-Saclay, School of Medicine, Le Kremlin-Bicêtre, France

AP-HP, Department of Respiratory and Intensive Care Medicine, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.

Morane Le Hiress

Function : Author

INSERM UMR_S 999, Hôpital Marie Lannelongue, Le Plessis-Robinson, France

Université Paris-Saclay, School of Medicine, Le Kremlin-Bicêtre, France

AP-HP, Department of Respiratory and Intensive Care Medicine, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.

Yuichi Tamura

Function : Author
PersonId : 800551
ORCID : 0000-0002-8727-7154
IdRef : 074667807

INSERM UMR_S 999, Hôpital Marie Lannelongue, Le Plessis-Robinson, France

Université Paris-Saclay, School of Medicine, Le Kremlin-Bicêtre, France

AP-HP, Department of Respiratory and Intensive Care Medicine, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.

Etienne-Marie Jutant

Function : Author
PersonId : 772690
ORCID : 0000-0002-1374-1890
IdRef : 22021106X

INSERM UMR_S 999, Hôpital Marie Lannelongue, Le Plessis-Robinson, France

Université Paris-Saclay, School of Medicine, Le Kremlin-Bicêtre, France

AP-HP, Department of Respiratory and Intensive Care Medicine, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.

Marie-Camille Chaumais

Function : Author

INSERM UMR_S 999, Hôpital Marie Lannelongue, Le Plessis-Robinson, France

Université Paris-Saclay, School of Medicine, Le Kremlin-Bicêtre, France

AP-HP, Department of Respiratory and Intensive Care Medicine, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.

Stéphane Bouchet

Function : Author

Département de Pharmacologie, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France.

Université de Bordeaux, INSERM U1219, Bordeaux, France.

Benjamin Maneglier

Function : Author

Service de Biologie Médicale, Centre Hospitalier de Versailles, Le Chesnay, France

Mathieu Molimard

Function : Author
PersonId : 760819
ORCID : 0000-0002-4346-8346
IdRef : 080590144

Université de Bordeaux, INSERM U1219, Bordeaux, France.

Département de Pharmacologie, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France

Philippe Rousselot

Function : Author
PersonId : 759734
ORCID : 0000-0001-6798-7805

Service d’Hématologie et d’Oncologie, Centre Hospitalier de Versailles, Le Chesnay, France

Université de Versailles Saint-Quentin-en-Yvelines

Olivier Sitbon

Function : Author
PersonId : 944445

INSERM UMR_S 999, Hôpital Marie Lannelongue, Le Plessis-Robinson, France

Université Paris-Saclay, School of Medicine, Le Kremlin-Bicêtre, France

AP-HP, Department of Respiratory and Intensive Care Medicine, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.

Gerald Simonneau

Function : Author

INSERM UMR_S 999, Hôpital Marie Lannelongue, Le Plessis-Robinson, France

Université Paris-Saclay, School of Medicine, Le Kremlin-Bicêtre, France

AP-HP, Department of Respiratory and Intensive Care Medicine, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.

David Montani

Function : Author
PersonId : 944435

INSERM UMR_S 999, Hôpital Marie Lannelongue, Le Plessis-Robinson, France

Université Paris-Saclay, School of Medicine, Le Kremlin-Bicêtre, France

AP-HP, Department of Respiratory and Intensive Care Medicine, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.

Marc Humbert

Function : Author
PersonId : 998406

INSERM UMR_S 999, Hôpital Marie Lannelongue, Le Plessis-Robinson, France

Université Paris-Saclay, School of Medicine, Le Kremlin-Bicêtre, France

AP-HP, Department of Respiratory and Intensive Care Medicine, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.

Domains

Life Sciences [q-bio] Cellular Biology Life Sciences [q-bio] Life Sciences [q-bio] Human health and pathology Cardiology and cardiovascular system Life Sciences [q-bio] Human health and pathology Pulmonology and respiratory tract

Christophe Guignabert : Connect in order to contact the contributor

https://www.hal.inserm.fr/inserm-02579754

Submitted on : Thursday, May 14, 2020-7:47:15 PM

Last modification on : Friday, October 14, 2022-9:11:32 AM

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inserm-02579754 , version 1 (14-05-2020)

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HAL Id : inserm-02579754 , version 1
DOI : 10.1172/JCI86249
PUBMEDCENTRAL : PMC5004960

Cite

Christophe Guignabert, Carole Phan, Andrei Seferian, Alice Huertas, Ly Tu, et al.. Dasatinib induces lung vascular toxicity and predisposes to pulmonary hypertension. Journal of Clinical Investigation, 2016, 126 (9), pp.3207-3218. ⟨10.1172/JCI86249⟩. ⟨inserm-02579754⟩

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Dasatinib induces lung vascular toxicity and predisposes to pulmonary hypertension

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