R. B. Berry, R. Brooks, and C. Gamaldo, AASM Scoring Manual Updates for 2017 (Version 2.4), J Clin Sleep Med, vol.13, issue.05, pp.665-666, 2017.

A. Malhotra and D. P. White, Obstructive sleep apnoea, Lancet, vol.360, issue.9328, pp.237-245, 2002.

S. Ancoli-israel, D. Kripke, W. Mason, and S. Messin, Comparisons of Home Sleep Recordings and Polysomnograms in Older Adults with Sleep Disorders, Sleep, vol.4, issue.3, pp.283-291, 1981.

C. V. Senaratna, J. L. Perret, and C. J. Lodge, Prevalence of obstructive sleep apnea in the general population: A systematic review, Sleep Med Rev, vol.34, pp.70-81, 2017.

F. Emamian, H. Khazaie, and M. Tahmasian, The Association Between Obstructive Sleep Apnea and Alzheimer's Disease: A Meta-Analysis Perspective, Front Aging Neurosci, vol.8, 2016.

K. Yaffe, A. M. Laffan, and S. L. Harrison, Sleep-Disordered Breathing, Hypoxia, and Risk of Mild Cognitive Impairment and Dementia in Older Women, JAMA, vol.306, issue.6, pp.613-619, 2011.

Y. Leng, C. T. Mcevoy, I. E. Allen, and K. Yaffe, Association of Sleep-Disordered Breathing With Cognitive Function and Risk of Cognitive Impairment: A Systematic Review and Meta-analysis, JAMA Neurol, vol.74, issue.10, pp.1237-1245, 2017.

R. S. Osorio, T. Gumb, and E. Pirraglia, Sleep-disordered breathing advances cognitive decline in the elderly, Neurology, vol.84, issue.19, pp.1964-1971, 2015.

X. Huang, S. Tang, X. Lyu, C. Yang, and X. Chen, Structural and functional brain alterations in obstructive sleep apnea: a multimodal meta-analysis, Sleep Med, vol.54, pp.195-204, 2019.

Y. Shi, L. Chen, and T. Chen, A Meta-analysis of Voxel-based Brain Morphometry Studies in Obstructive, Sleep Apnea. Sci Rep, vol.7, issue.1, p.10095, 2017.

M. Tahmasian, I. Rosenzweig, and S. B. Eickhoff, Structural and functional neural adaptations in obstructive sleep apnea: An activation likelihood estimation metaanalysis, Neurosci Biobehav Rev, vol.65, pp.142-156, 2016.

A. Baril, K. Gagnon, and P. Brayet, Gray Matter Hypertrophy and Thickening with Obstructive Sleep Apnea in Middle-aged and Older Adults, Am J Respir Crit Care Med, vol.195, issue.11, pp.1509-1518, 2017.

I. Rosenzweig, M. J. Kempton, and W. R. Crum, Hippocampal Hypertrophy and Sleep Apnea: A Role for the Ischemic Preconditioning? Annunziato L, PLoS One, vol.8, issue.12, p.83173, 2013.

C. Innes, P. T. Kelly, M. Hlavac, T. R. Melzer, and R. D. Jones, Decreased Regional Cerebral Perfusion in Moderate-Severe Obstructive Sleep Apnoea during Wakefulness, Sleep, vol.38, issue.5, pp.699-706, 2015.

A. Baril, K. Gagnon, and C. Arbour, Regional Cerebral Blood Flow during Wakeful Rest in Older Subjects with Mild to Severe Obstructive Sleep Apnea, Sleep, vol.38, issue.9, pp.1439-1449, 2015.

J. S. Kim, J. H. Seo, and M. Kang, Effect of continuous positive airway pressure on regional cerebral blood flow in patients with severe obstructive sleep apnea syndrome

, Sleep Med, vol.32, pp.122-128, 2017.

S. Nie, D. Peng, H. Gong, H. Li, L. Chen et al., Resting cerebral blood flow alteration in severe obstructive sleep apnoea: an arterial spin labelling perfusion fMRI study, Sleep Breath, vol.21, issue.2, pp.487-495, 2017.

X. Bu, Y. Liu, and Q. Wang, Serum amyloid-beta levels are increased in patients with obstructive sleep apnea syndrome, Sci Rep, vol.5, issue.1, p.13917, 2015.

O. M. Bubu, E. Pirraglia, and A. G. Andrade, Obstructive sleep apnea and longitudinal Alzheimer's disease biomarker changes, Sleep, vol.42, issue.6, 2019.

C. Liguori, N. B. Mercuri, and F. Izzi, Obstructive Sleep Apnea is Associated With Early but Possibly Modifiable Alzheimer's Disease Biomarkers Changes, Sleep, vol.40, issue.5, 2017.

R. A. Sharma, A. W. Varga, and O. M. Bubu, Obstructive Sleep Apnea Severity Affects Amyloid Burden in Cognitively Normal Elderly. A Longitudinal Study, Am J Respir Crit Care Med, vol.197, issue.7, pp.933-943, 2018.

A. Elias, T. Cummins, and R. Tyrrell, Risk of Alzheimer's Disease in Obstructive Sleep Apnea Syndrome: Amyloid-? and Tau Imaging, J Alzheimer's Dis, vol.66, issue.2, pp.733-741, 2018.

C. Yun, H. Lee, and S. K. Lee, Amyloid Burden in Obstructive Sleep Apnea

R. X. Aviles-reyes, M. F. Angelo, A. Villarreal, H. Rios, A. Lazarowski et al., Intermittent hypoxia during sleep induces reactive gliosis and limited neuronal death in rats: implications for sleep apnea, J Neurochem, vol.112, issue.4, pp.854-869, 2010.

K. Li, J. Zhang, Y. Qin, and Y. Wei, Association between Serum Homocysteine Level and Obstructive Sleep Apnea: A Meta-Analysis, Biomed Res Int, p.7234528, 2017.

M. A. Daulatzai, Death by a Thousand Cuts in Alzheimer's Disease: Hypoxia-The Prodrome, Neurotox Res, vol.24, issue.2, pp.216-243, 2013.

A. W. Bero, P. Yan, and J. H. Roh, Neuronal activity regulates the regional vulnerability to amyloid-? deposition, Nat Neurosci, vol.14, issue.6, pp.750-756, 2011.

M. E. Raichle, A. M. Macleod, A. Z. Snyder, W. J. Powers, D. A. Gusnard et al., A default mode of brain function, Proc Natl Acad Sci, vol.98, issue.2, pp.676-682, 2001.

R. L. Buckner, J. Sepulcre, and T. Talukdar, Cortical Hubs Revealed by Intrinsic Functional Connectivity: Mapping, Assessment of Stability

, Alzheimer's Disease, J Neurosci, vol.29, issue.6, pp.1860-1873, 2009.

J. R. Cirrito, K. A. Yamada, and M. B. Finn, Synaptic Activity Regulates Interstitial Fluid Amyloid-? Levels In Vivo, Neuron, vol.48, issue.6, pp.913-922, 2005.

J. W. Kinney, S. M. Bemiller, A. S. Murtishaw, A. M. Leisgang, A. M. Salazar et al., Inflammation as a central mechanism in Alzheimer's disease, Transl Res Clin Interv, vol.4, pp.575-590, 2018.

J. Fortea, E. Vilaplana, and D. Alcolea, Cerebrospinal fluid ?-amyloid and phospho-tau biomarker interactions affecting brain structure in preclinical Alzheimer disease, Ann Neurol, vol.76, issue.2, pp.223-230, 2014.

J. Pegueroles, E. Vilaplana, and V. Montal, Longitudinal brain structural changes in preclinical Alzheimer's disease, vol.13, pp.499-509, 2017.

Y. Stern, E. M. Arenaza-urquijo, and D. Bartrés-faz, Defining and investigating cognitive reserve, brain reserve, and brain maintenance

. Dement, , 2018.

M. Olaithe, R. S. Bucks, D. R. Hillman, and P. R. Eastwood, Cognitive deficits in obstructive sleep apnea: Insights from a meta-review and comparison with deficits observed in COPD, insomnia, and sleep deprivation, Sleep Med Rev, vol.38, pp.39-49, 2018.

L. L. Boland, E. Shahar, and C. Iber, Measures of cognitive function in persons with varying degrees of sleep-disordered breathing: the Sleep Heart Health Study, J Sleep Res, vol.11, issue.3, pp.265-272, 2002.

E. Sforza, F. Roche, and C. Thomas-anterion, Cognitive Function and Sleep Related Breathing Disorders in a Healthy Elderly Population: the Synapse Study, Sleep, vol.33, issue.4, pp.515-521, 2010.

, Abbreviations: AAL, Automated Anatomical Labelling

, FDG, 18 F-fluorodeoxyglucose, L, left; PCC, posterior cingulate cortex

, PVE, partial volume effect

R. Roi, brain perfusion (early Florbetapir-PET, n=124) and glucose metabolism (FDG-PET, n=87) data, extracted from PVE-corrected and uncorrected PET images in standardized ROIs of the AAL Atlas overlapping with the significant clusters obtained in the voxel-wise analyses. The "composite" ROI is a meta-ROI comprising all the individual AAL ROIs listed below (i.e., left and right PCC, cuneus, precuneus, lingual and calcarine regions). The statistical threshold for significance was set, Results of between-group comparisons (SDB+>SDB-) for amyloid burden (late Florbetapir-PET, n=125)

H. W. Müller-gärtner, J. M. Links, and J. L. Prince, Measurement of radiotracer concentration in brain gray matter using positron emission tomography: MRI-based correction for partial volume effects, J Cereb Blood Flow Metab, vol.12, issue.4, pp.571-583, 1992.

L. Joie, R. Perrotin, A. De, L. Sayette, and V. , Hippocampal subfield volumetry in mild cognitive impairment, NeuroImage Clin, vol.3, pp.155-162, 2013.
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