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Journal Articles Neuroscience Letters Year : 2020

The cerebral cortex is a substrate of multiple interactions between GABAergic interneurons and oligodendrocyte lineage cells

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Abstract

In the cerebral cortex, GABAergic interneurons and oligodendrocyte lineage cells share different characteristics and interact despite being neurons and glial cells, respectively. These two distinct cell types share common embryonic origins and are born from precursors expressing similar transcription factors. Moreover, they highly interact with each other through different communication mechanisms during development. Notably, cortical oligodendrocyte precursor cells (OPCs) receive a major and transient GABAergic synaptic input, preferentially from parvalbumin-expressing interneurons, a specific interneuron subtype recently recognized as highly mye-linated. In this review, we highlight the similarities and interactions between GABAergic interneurons and oligodendrocyte lineage cells in the cerebral cortex and suggest potential roles of this intimate interneuron-oligodendroglia relationship in cortical construction. We also propose new lines of research to understand the role of the close link between interneurons and oligodendroglia during cortical development and in pathological conditions such as schizophrenia.
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inserm-02571183 , version 1 (12-05-2020)

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Najate Benamer, Marie Vidal, Maria Cecilia Angulo. The cerebral cortex is a substrate of multiple interactions between GABAergic interneurons and oligodendrocyte lineage cells. Neuroscience Letters, 2020, 715, pp.134615. ⟨10.1016/j.neulet.2019.134615⟩. ⟨inserm-02571183⟩
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