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, -methyl-1H-190 benzimidazol-5-yl)-1H-imidazo[4,5-c]pyridin-2-yl]-1,2,5-oxadiazol-3-amine dihydrochloride) 191 converts the antigen-specific effector/memory T cells into Foxp3+ regulatory T cells, contrast, inhibition of CDK8/19 by AS2863619

. Mechanistically, AS2863619 keeps the active state of STAT5 (phosphorylation at tyrosine in the

, Although not observed under in vitro 197 conditions, in vivo AS2863619-induced Tregs also displayed stable Treg-specific demethylation 198 features at Foxp3 and Helios gene loci. Moreover, AS treatment rendered protective effects in 199 the mouse models of allergy and autoimmune diseases by increasing the Foxp3+ T cells, C-ter) domain), which binds to regulatory regions of the Foxp3 locus majorily at 194