Pulmonary veno-occlusive disease, Eur Respir J, vol.47, pp.1518-1534, 2016. ,
URL : https://hal.archives-ouvertes.fr/inserm-02561102
Clinical phenotypes and outcomes of heritable and sporadic pulmonary veno-occlusive disease: a population-based study, Lancet Respir Med, vol.5, pp.125-134, 2017. ,
URL : https://hal.archives-ouvertes.fr/inserm-01436297
EIF2AK4 mutations cause pulmonary veno-occlusive disease, a recessive form of pulmonary hypertension, Nat Genet, vol.46, pp.65-69, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01514453
Pulmonary veno-occlusive disease as an occupational lung disease, Lancet Respir Med, vol.5, p.19, 2017. ,
The amino acid sensor GCN2 inhibits inflammatory responses to apoptotic cells promoting tolerance and suppressing systemic autoimmunity, Proc Natl Acad Sci U S A, vol.112, pp.10774-10779, 2015. ,
The integrated stress response system in cardiovascular disease, Drug Discov Today, vol.23, pp.920-929, 2018. ,
ERG-APLNR axis controls pulmonary venule endothelial proliferation in pulmonary veno-occlusive disease, Circulation, vol.130, pp.1179-1191, 2014. ,
Mitomycin-Induced Pulmonary Veno-Occlusive Disease: Evidence From Human Disease and Animal Models, Circulation, vol.132, pp.834-847, 2015. ,
ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis, J Clin Invest, vol.125, pp.2592-2608, 2015. ,
The genetic basis of pulmonary arterial hypertension, Hum Genet, vol.133, pp.471-479, 2014. ,
MAPK signal pathways in the regulation of cell proliferation in mammalian cells, Cell Res, vol.12, pp.9-18, 2002. ,
A simple method to assess in vivo proliferation in lung vasculature with EdU: the case of MMC-induced PVOD in rat, Anal Cell Pathol Amst, p.326385, 2015. ,
Ion Channels in Pulmonary Hypertension: A Therapeutic Interest?, Int J Mol Sci, vol.19, 2018. ,
Potassium Channel Subfamily K Member 3 (KCNK3) Contributes to the Development of Pulmonary Arterial Hypertension, Circulation, vol.133, pp.1371-1385, 2016. ,
Characterization of Kcnk3-Mutated Rat, a Novel Model of Pulmonary Hypertension, Circ Res, vol.125, pp.678-695, 2019. ,
URL : https://hal.archives-ouvertes.fr/hal-02346635
Cross talk between endothelial and smooth muscle cells in pulmonary hypertension: critical role for serotonin-induced smooth muscle hyperplasia, Circulation, vol.113, pp.1857-1864, 2006. ,
General Control Nonderepressible 2 (GCN2) Kinase Inhibits Target of Rapamycin Complex 1 in Response to Amino Acid Starvation in Saccharomyces cerevisiae, J Biol Chem, vol.292, pp.2660-2669, 2017. ,
mTOR signaling promotes stem cell activation via counterbalancing BMPmediated suppression during hair regeneration, J Mol Cell Biol, vol.7, pp.62-72, 2015. ,
Ten Dijke P, Rabinovitch M. FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension, J Clin Invest, vol.123, pp.3600-3613, 2013. ,
Pathologic assessment of vasculopathies in pulmonary hypertension, J Am Coll Cardiol, vol.43, pp.25-32, 2004. ,
BMPR2 mutation status influences bronchial vascular changes in pulmonary arterial hypertension, Eur Respir J, vol.48, pp.1668-1681, 2016. ,
Pulmonary vascular remodeling patterns and expression of general control nonderepressible 2 (GCN2) in pulmonary venoocclusive disease, J Heart Lung Transplant Off Publ Int Soc Heart Transplant, 2017. ,
TASK-1 (KCNK3) channels in the lung: from cell biology to clinical implications, Eur Respir J, vol.50, 2017. ,
Global Pulmonary Vascular Remodeling in Pulmonary Hypertension Associated with Heart Failure and Preserved or Reduced Ejection Fraction, Circulation, vol.137, pp.1796-1810, 2018. ,
Cardiotoxicity of chemotherapeutic agents: incidence, treatment and prevention, Drug Saf, vol.22, pp.263-302, 2000. ,
Non-Invasive Assessment of Pulmonary Vascular Resistance in Pulmonary Hypertension: Current Knowledge and Future Direction, Heart Lung Circ, vol.26, pp.323-330, 2017. ,
Evidence of Echocardiographic Markers of Pulmonary Vascular Disease in Asymptomatic Infants Born Preterm at One Year of Age, J Pediatr, vol.197, pp.48-56, 2018. ,
TGF? and BMPRII signalling pathways in the pathogenesis of pulmonary arterial hypertension, Drug Discov Today, vol.24, pp.703-716, 2019. ,
The Dual Role of Bone Morphogenetic Proteins in Cancer, Mol Ther Oncolytics, vol.8, pp.1-13, 2018. ,
FHIT, a Novel Modifier Gene in Pulmonary Arterial Hypertension, Am J Respir Crit Care Med, vol.199, pp.83-98, 2019. ,
Gene expression in BMPR2 mutation carriers with and without evidence of pulmonary arterial hypertension suggests pathways relevant to disease penetrance, BMC Med Genomics, vol.1, p.45, 2008. ,
BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo, J Cell Sci, vol.123, pp.1684-1692, 2010. ,
,
BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis, J Cell Sci, vol.120, pp.964-972, 2007. ,
,
, Raf/ERK drives the proliferative and invasive phenotype of BMPR2-silenced pulmonary artery endothelial cells, Am J Physiol Lung Cell Mol Physiol, vol.310, pp.187-201, 2016.
High-throughput mapping of a dynamic signaling network in mammalian cells, Science, vol.307, pp.1621-1625, 2005. ,
4-Phenylbutyric Acid Induces Protection against Pulmonary Arterial Hypertension in Rats, PloS One, vol.11, p.157538, 2016. ,
Understanding the Similarities and Differences between Hepatic and Pulmonary Veno-Occlusive Disease, Am J Pathol, vol.189, pp.1159-1175, 2019. ,
Translational control in the endoplasmic reticulum stress response, J Clin Invest, vol.110, pp.1383-1388, 2002. ,
, A novel mechanism for the control of translation initiation by amino acids, mediated by phosphorylation of eukaryotic initiation factor 2B. -PubMed -NCBI
Toll-like receptor activation suppresses ER stress factor CHOP and translation inhibition through activation of eIF2B, Nat Cell Biol, vol.14, pp.192-200, 2012. ,
Signaling through alternative Integrated Stress Response pathways compensates for GCN2 loss in a mouse model of soft tissue sarcoma, Sci Rep, vol.5, p.11781, 2015. ,
Role of GCN2-Independent Signaling Through a Noncanonical PERK/NRF2 Pathway in the Physiological Responses to Dietary Methionine Restriction, Diabetes, vol.65, pp.1499-1510, 2016. ,
Implication of Nrf2 and ATF4 in differential induction of CHOP by proteasome inhibition in thyroid cancer cells, Biochim Biophys Acta, vol.1823, pp.1395-1404, 2012. ,
Activation of Nrf2 Attenuates Pulmonary Vascular Remodeling via Inhibiting Endothelial-to-Mesenchymal Transition: an Insight from a Plant Polyphenol, Int J Biol Sci, vol.13, pp.1067-1081, 2017. ,
ERG is required for the differentiation of embryonic stem cells along the endothelial lineage, BMC Dev Biol, vol.9, p.72, 2009. ,
The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells, Nat Immunol, vol.9, pp.810-819, 2008. ,
Synergistic Role of Endothelial ERG and FLI1 in Mediating Pulmonary Vascular Homeostasis, Am J Respir Cell Mol Biol, vol.57, pp.121-131, 2017. ,
The site and nature of airway obstruction after lung transplantation, Am J Respir Crit Care Med, vol.189, pp.292-300, 2014. ,
Comparative Analysis of piggyBac, CRISPR/Cas9 and TALEN Mediated BAC Transgenesis in the Zygote for the Generation of, Humanized SIRPA Rats. Sci Rep, vol.6, p.31455, 2016. ,
URL : https://hal.archives-ouvertes.fr/inserm-02150699
Homology-directed repair in rodent zygotes using Cas9 and TALEN engineered proteins, Sci Rep, vol.5, p.14410, 2015. ,
A Rapid and Cost-Effective Method for Genotyping Genome-Edited Animals: A Heteroduplex Mobility Assay Using Microfluidic Capillary Electrophoresis, J Genet Genomics, vol.43, pp.341-348, 2016. ,
URL : https://hal.archives-ouvertes.fr/inserm-02150677
Mitomycin-Induced Pulmonary Veno-Occlusive Disease: Evidence From Human Disease and Animal Models, Circulation, vol.132, pp.834-847, 2015. ,
Evidence of Echocardiographic Markers of Pulmonary Vascular Disease in Asymptomatic Infants Born Preterm at One Year of Age, J Pediatr, vol.197, pp.48-56, 2018. ,
Non-Invasive Assessment of Pulmonary Vascular Resistance in Pulmonary Hypertension: Current Knowledge and Future Direction, Heart Lung Circ, vol.26, pp.323-330, 2017. ,
Loss of KCNK3 is a hallmark of RV hypertrophy/dysfunction associated with pulmonary hypertension, Cardiovasc Res, vol.114, pp.880-893, 2018. ,
,
Chemotherapy-induced pulmonary hypertension: role of alkylating agents ,
, Am J Pathol, vol.185, pp.356-371, 2015.
,
Potassium Channel Subfamily K Member 3 (KCNK3) Contributes to the Development of Pulmonary Arterial Hypertension, Circulation, vol.133, pp.1371-1385, 2016. ,
The acid-sensitive potassium channel TASK-1 in rat cardiac muscle, Cardiovasc Res, vol.75, pp.59-68, 2007. ,
NMDA-Type Glutamate Receptor Activation Promotes Vascular Remodeling and Pulmonary Arterial Hypertension, Circulation, vol.137, pp.2371-2389, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-02411759
Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension, Nat Med, vol.21, pp.777-785, 2015. ,
Ten Dijke P, Rabinovitch M. FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension, J Clin Invest, vol.123, pp.3600-3613, 2013. ,
Baseline echocardiographic values for adult male rats, J Am Soc Echocardiogr, vol.17, pp.161-167, 2004. ,
Doxorubicin cardiotoxicity in the rat: an in vivo characterization, J Am Assoc Lab Anim Sci, vol.46, pp.20-32, 2007. ,