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Journal articles
OCT Analysis of Very Early Strut Coverage of the Synergy Stent in Non-ST Segment Elevation Acute Coronary Syndrome Patients.
Abstract : OBJECTIVES:
Early endothelialization of drug-eluting stent (DES) is a major challenge to reduce the risk of stent thrombosis and the duration of dual-antiplatelet therapy (DAPT) in high bleeding-risk patients. The aim of the present study is to evaluate very early strut coverage with optical coherence tomography (OCT) of the Synergy stent (Boston Scientific) at 1 month in non-ST segment elevation acute coronary syndrome (NSTE-ACS) patients.
METHODS:
This substudy of the EARLY trial prospectively included NSTE-ACS patients treated with the Synergy DES. OCT analysis of the Synergy stent was performed during a staged PCI of additional lesions at 1 month. The primary endpoint was the percentage of covered struts assessed with OCT at 1 month.
RESULTS:
Twenty-four patients were included, with a mean stent length of 35.9 ± 10.1 mm per patient. The rate of covered struts was 78.5% out of 3839 struts analyzed. Nineteen patients (79.2%) had at least 70% of their struts covered. The average neointimal thickness was 0.0508 ± 0.016 mm.
CONCLUSIONS:
In NSTE-ACS patients undergoing culprit percutaneous coronary intervention with the Synergy stent, the rate of covered struts at 1 month was 78.5%. This rapid coverage is in line with the results of clinical trials demonstrating the safety of short-duration DAPT in selected patients who are at high bleeding risk and treated with new-generation DES options.
https://www.hal.inserm.fr/inserm-02559861
Contributor : Christine Dupuis Connect in order to contact the contributor
Submitted on : Thursday, April 30, 2020 - 6:04:57 PM
Last modification on : Tuesday, October 19, 2021 - 10:59:17 PM
Contributor : Christine Dupuis Connect in order to contact the contributor
Submitted on : Thursday, April 30, 2020 - 6:04:57 PM
Last modification on : Tuesday, October 19, 2021 - 10:59:17 PM