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(. and C. , Jurkat cells were treated with 10 ?M of Takinib (B) or 1 ?M Trametinib (C) for, p.1

, Cell lysates were prepared and subjected to Western blotting analysis as indicated

, Western blotting analysis of lysates from Jurkat cells transfected with an individual siRNA for TAK1 or scramble nonspecific siRNA, and stimulated as in (A)

, Carolina Alves Nicolau: Conceptualization, Methodology, Investigation, Writing -Original Draft, Writing -Review & Editing, Funding Acquisition. Julie Gavard: Supervision, Writing -Review & Editing, Funding Acquisition. Nicolas Bidère: Conceptualization, Writing -Original Draft, Writing -Review & Editing, Funding Acquisition ? Interfering with TAK1 enhances the proteolysis of MALT1 substrates

, ? TAK1 action on MALT1 activity requires the CARMA1-BCL10-MALT1 complex

, ? TAK1 inhibition augments CARMA1-BCL10-MALT1 assembly and MALT1 ubiquitination