Human Trophoblast in Trisomy 21: A Model for Cell–Cell Fusion Dynamic Investigation - Archive ouverte HAL Access content directly
Book Sections Year : 2011

Human Trophoblast in Trisomy 21: A Model for Cell–Cell Fusion Dynamic Investigation

(1) , (1) , (1) , (1) , (1)
1

Abstract

Trophoblastic cell fusion is one essential step of the human trophoblast differentiation leading to formation of the syncytiotrophoblast, site of the numerous placental functions. This process is multifactorial and finely regulated. Using the physiological model of primary culture of trophoblastic cells isolated from human placenta, we have identified different membrane proteins directly involved in trophoblastic cell fusion: connexin 43, ZO-1 and recently syncytins. These fusogenic membrane retroviral envelop glycoproteins: syncytin-1 (encoded by the HERV-W gene) and syncytin-2 (encoded by the FRD gene) and their receptors are major factors involved in human placental development. Disturbances of syncytiotrophoblast formation are observed in trisomy 21-affected placentas. Overexpression of the copper/zinc superoxide dismutase (SOD-1), encoded by chromosome 21 as well as an abnormal hCG signaling are implicated in the defect of syncytiotrophoblast formation. This abnormal trophoblast fusion and differentiation in trisomy 21-affected placenta is reversible in vitro by different ways.
Not file

Dates and versions

inserm-02556149 , version 1 (27-04-2020)

Identifiers

Cite

André Malassiné, Guillaume Pidoux, Pascale Gerbaud, Jean Louis Frendo, Danièle Evain-Brion. Human Trophoblast in Trisomy 21: A Model for Cell–Cell Fusion Dynamic Investigation. Advances in Experimental Medicine and Biology book series, pp.103-112, 2011, ⟨10.1007/978-94-007-0782-5_4⟩. ⟨inserm-02556149⟩
21 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More