C. Alexander, M. Votruba, U. E. Pesch, D. L. Thiselton, S. Mayer et al., OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28, Nat Genet, vol.26, pp.211-215, 2000.

T. Ban, J. A. Heymann, Z. Song, J. E. Hinshaw, and D. C. Chan, OPA1 disease alleles causing dominant optic atrophy have defects in cardiolipin-stimulated GTP hydrolysis and membrane tubulation, Hum Mol Genet, vol.19, pp.2113-2122, 2010.

S. J. Beebe, R. Holloway, S. R. Rannels, and J. D. Corbin, Two classes of cAMP analogs which are selective for the two different cAMP-binding sites of type II protein kinase demonstrate synergism when added together to intact adipocytes, J Biol Chem, vol.259, pp.3539-3547, 1984.

E. J. Blanchette-mackie, N. K. Dwyer, T. Barber, R. A. Coxey, T. Takeda et al., Perilipin is located on the surface layer of intracellular lipid droplets in adipocytes, J Lipid Res, vol.36, pp.1211-1226, 1995.

S. Bolte and F. P. Cordelieres, A guided tour into subcellular colocalization analysis in light microscopy, J Microsc, vol.224, pp.213-232, 2006.
URL : https://hal.archives-ouvertes.fr/hal-00132481

D. L. Brasaemle, G. Dolios, L. Shapiro, and R. Wang, Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-L1 adipocytes, J Biol Chem, vol.279, pp.46835-46842, 2004.

D. L. Brasaemle, D. M. Levin, D. C. Adler-wailes, and C. Londos, The lipolytic stimulation of 3T3-L1 adipocytes promotes the translocation of hormone-sensitive lipase to the surfaces of lipid storage droplets, Biochim Biophys Acta, vol.1483, pp.251-262, 2000.

D. L. Brasaemle, B. Rubin, I. A. Harten, J. Gruia-gray, A. R. Kimmel et al., Perilipin A increases triacylglycerol storage by decreasing the rate of triacylglycerol hydrolysis, J Biol Chem, vol.275, pp.38486-38493, 2000.

D. Bridges, J. A. Macdonald, B. Wadzinski, and G. B. Moorhead, Identification and characterization of D-AKAP1 as a major adipocyte PKA and PP1 binding protein, Biochem Biophys Res Commun, vol.346, pp.351-357, 2006.

C. R. Carlson, B. Lygren, T. Berge, N. Hoshi, W. Wong et al., Delineation of type I protein kinase A-selective signaling events using an RI anchoring disruptor, J Biol Chem, vol.281, pp.21535-21545, 2006.

D. W. Carr, Z. E. Hausken, I. D. Fraser, R. E. Stofko-hahn, and J. D. Scott, Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain, J Biol Chem, vol.267, pp.13376-13382, 1992.

A. Cederberg, L. M. Gronning, B. Ahren, K. Tasken, P. Carlsson et al., FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance, Cell, vol.106, pp.563-573, 2001.

A. Chaudhry, C. Zhang, and J. G. Granneman, Characterization of RII(beta) and D-AKAP1 in differentiated adipocytes, Am J Physiol Cell Physiol, vol.282, pp.205-212, 2002.

S. Cipolat, O. Martins-de-brito, D. Zilio, B. Scorrano, and L. , OPA1 requires mitofusin 1 to promote mitochondrial fusion, Proc Natl Acad Sci, vol.101, pp.15927-15932, 2004.

D. E. Cummings, E. P. Brandon, J. V. Planas, K. Motamed, R. L. Idzerda et al., Genetically lean mice result from targeted disruption of the RII beta subunit of protein kinase A, Nature, vol.382, pp.622-626, 1996.

C. Delettre, G. Lenaers, J. M. Griffoin, N. Gigarel, C. Lorenzo et al., Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy, Nat Genet, vol.26, pp.207-210, 2000.

D. Diviani and J. D. Scott, AKAP signaling complexes at the cytoskeleton, J Cell Sci, vol.114, pp.1431-1437, 2001.

S. Durgerian and S. S. Taylor, The consequences of introducing an autophosphorylation site into the type I regulatory subunit of cAMP-dependent protein kinase, J Biol Chem, vol.264, pp.9807-9813, 1989.

G. Enrique-tarancon, L. Marti, N. Morin, J. M. Lizcano, M. Unzeta et al., Role of semicarbazide-sensitive amine oxidase on glucose transport and GLUT4 recruitment to the cell surface in adipose cells, J Biol Chem, vol.273, pp.8025-8032, 1998.

J. N. Fain and J. A. Garcija-sainz, Adrenergic regulation of adipocyte metabolism, J Lipid Res, vol.24, pp.945-966, 1983.

I. D. Fraser, M. Cong, J. Kim, E. N. Rollins, Y. Daaka et al., Assembly of an A kinase-anchoring protein-beta(2)-adrenergic receptor complex facilitates receptor phosphorylation and signaling, Curr Biol, vol.10, pp.409-412, 2000.

G. Fredrikson, H. Tornqvist, and P. Belfrage, Hormone-sensitive lipase and monoacylglycerol lipase are both required for complete degradation of adipocyte triacylglycerol, Biochim Biophys Acta, vol.876, pp.288-293, 1986.

C. Frezza, S. Cipolat, O. Martins-de-brito, M. Micaroni, G. V. Beznoussenko et al., OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion, Cell, vol.126, pp.177-189, 2006.

H. Giudicelli, N. Combes-pastre, and J. Boyer, Lipolytic activity of adipose tissue. IV. The diacylglycerol lipase activity of human adipose tissue, Biochim Biophys Acta, vol.369, pp.25-33, 1974.

M. G. Gold, B. Lygren, P. Dokurno, N. Hoshi, G. Mcconnachie et al., Molecular basis of AKAP specificity for PKA regulatory subunits, Mol Cell, vol.24, pp.383-395, 2006.

A. S. Greenberg, J. J. Egan, S. A. Wek, N. B. Garty, E. J. Blanchette-mackie et al., Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets, J Biol Chem, vol.266, pp.11341-11346, 1991.

A. S. Greenberg, J. J. Egan, S. A. Wek, M. Jr, M. C. Londos et al., Isolation of cDNAs for perilipins A and B: sequence and expression of lipid droplet-associated proteins of adipocytes, Proc Natl Acad Sci, vol.90, pp.12035-12039, 1993.

G. Haemmerle, R. Zimmermann, M. Hayn, C. Theussl, G. Waeg et al., Hormone-sensitive lipase deficiency in mice causes diglyceride accumulation in adipose tissue, muscle, and testis, J Biol Chem, vol.277, pp.4806-4815, 2002.

Z. E. Hausken, V. M. Coghlan, and J. D. Scott, Overlay, ligand blotting, and band-shift techniques to study kinase anchoring, Methods Mol Biol, vol.88, pp.47-64, 1998.

F. W. Herberg, A. Maleszka, T. Eide, L. Vossebein, and K. Tasken, Analysis of A-kinase anchoring protein (AKAP) interaction with protein kinase A (PKA) regulatory subunits: PKA isoform specificity in AKAP binding, J Mol Biol, vol.298, pp.329-339, 2000.

N. Ishihara, Y. Fujita, T. Oka, and K. Mihara, Regulation of mitochondrial morphology through proteolytic cleavage of OPA1, EMBO J, vol.25, pp.2966-2977, 2006.

E. Jarnaess, A. Ruppelt, A. J. Stokka, B. Lygren, J. D. Scott et al., Dual specificity A-kinase anchoring proteins (AKAPs) contain an additional binding region that enhances targeting of protein kinase A type I, J Biol Chem, vol.283, pp.33708-33718, 2008.

C. M. Jenkins, D. J. Mancuso, W. Yan, H. F. Sims, B. Gibson et al., Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities, J Biol Chem, vol.279, pp.48968-48975, 2004.

C. R. Kahn, L. Chen, and S. E. Cohen, Unraveling the mechanism of action of thiazolidinediones, J Clin Invest, vol.106, pp.1305-1307, 2000.

A. R. Kimmel, D. L. Brasaemle, M. Mcandrews-hill, C. Sztalryd, and C. Londos, Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular, lipid storage droplet proteins, J Lipid Res, vol.51, pp.468-471, 2009.

F. S. Kinderman, C. Kim, S. Von-daake, Y. Ma, B. Q. Pham et al., A dynamic mechanism for AKAP binding to RII isoforms of cAMP-dependent protein kinase, Mol Cell, vol.24, pp.397-408, 2006.

T. Kita, H. Nishida, H. Shibata, S. Niimi, T. Higuti et al., Possible role of mitochondrial remodelling on cellular triacylglycerol accumulation, J Biochem, vol.146, pp.787-796, 2009.

C. Londos, D. L. Brasaemle, C. J. Schultz, J. P. Segrest, and A. R. Kimmel, Perilipins, ADRP, and other proteins that associate with intracellular neutral lipid droplets in animal cells, Semin Cell Dev Biol, vol.10, pp.51-58, 1999.

J. J. Michel and J. D. Scott, AKAP mediated signal transduction, Annu Rev Pharmacol Toxicol, vol.42, pp.235-257, 2002.

T. Misaka, T. Miyashita, and Y. Kubo, Primary structure of a dynamin-related mouse mitochondrial GTPase and its distribution in brain, subcellular localization, and effect on mitochondrial morphology, J Biol Chem, vol.277, pp.15834-15842, 2002.

S. Nomura, H. Kawanami, H. Ueda, T. Kizaki, H. Ohno et al., Possible mechanisms by which adipocyte lipolysis is enhanced in exercise-trained rats, Biochem Biophys Res Commun, vol.295, pp.236-242, 2002.

A. Olichon, L. Baricault, N. Gas, E. Guillou, A. Valette et al., Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis, J Biol Chem, vol.278, pp.7743-7746, 2003.

A. Olichon, L. J. Emorine, E. Descoins, L. Pelloquin, L. Brichese et al., The human dynamin-related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter-membrane space, FEBS Lett, vol.523, pp.171-176, 2002.

J. Osuga, S. Ishibashi, T. Oka, H. Yagyu, R. Tozawa et al., Targeted disruption of hormone-sensitive lipase results in male sterility and adipocyte hypertrophy, but not in obesity, Proc Natl Acad Sci, vol.97, pp.787-792, 2000.

C. Oswald, U. Krause-buchholz, and G. Rodel, Knockdown of human COX17 affects assembly and supramolecular organization of cytochrome c oxidase, J Mol Biol, vol.389, pp.470-479, 2009.

G. Pidoux and K. Tasken, Specificity and spatial dynamics of PKA signaling organized by A kinase anchoring proteins, J Mol Endocrinol, vol.44, pp.271-284, 2010.

A. M. Robinson-steiner, S. J. Beebe, S. R. Rannels, and J. D. Corbin, Microheterogeneity of type II cAMP-dependent protein kinase in various mammalian species and tissues, J Biol Chem, vol.259, pp.10596-10605, 1984.

A. Ruppelt, R. Mosenden, M. Gronholm, E. M. Aandahl, D. Tobin et al., Inhibition of T cell activation by cyclic adenosine 5 0 -monophosphate requires lipid raft targeting of protein kinase A type I by the A-kinase anchoring protein ezrin, J Immunol, vol.179, pp.5159-5168, 2007.

M. Satoh, T. Hamamoto, N. Seo, Y. Kagawa, and H. Endo, Differential sublocalization of the dynamin-related protein OPA1 isoforms in mitochondria, Biochem Biophys Res Commun, vol.300, pp.482-493, 2003.

H. Sesaki, S. M. Southard, M. P. Yaffe, and R. E. Jensen, Mgm1p, a dynamin-related GTPase, is essential for fusion of the mitochondrial outer membrane, Mol Biol Cell, vol.14, pp.2342-2356, 2003.

K. G. Soni, R. Lehner, P. Metalnikov, O. Donnell, P. Semache et al., Carboxylesterase 3 (EC 3.1.1.1) is a major adipocyte lipase, J Biol Chem, vol.279, pp.40683-40689, 2004.

S. C. Souza, K. V. Muliro, L. Liscum, P. Lien, M. T. Yamamoto et al., Modulation of hormone-sensitive lipase and protein kinase Amediated lipolysis by perilipin A in an adenoviral reconstituted system, J Biol Chem, vol.277, pp.8267-8272, 2002.

M. Spinazzi, S. Cazzola, M. Bortolozzi, A. Baracca, E. Loro et al., A novel deletion in the GTPase domain of OPA1 causes defects in mitochondrial morphology and distribution, but not in function, Hum Mol Genet, vol.17, pp.3291-3302, 2008.

A. J. Stokka, F. Gesellchen, C. R. Carlson, J. D. Scott, F. W. Herberg et al., Characterization of A-kinase-anchoring disruptors using a solution-based assay, Biochem J, vol.400, pp.493-499, 2006.

V. Subramanian, A. Garcia, A. Sekowski, and D. L. Brasaemle, Hydrophobic sequences target and anchor perilipin A to lipid droplets, J Lipid Res, vol.45, pp.1983-1991, 2004.

J. T. Tansey, A. M. Huml, R. Vogt, K. E. Davis, J. M. Jones et al., Functional studies on native and mutated forms of perilipins. A role in protein kinase A-mediated lipolysis of triacylglycerols, J Biol Chem, vol.278, pp.8401-8406, 2003.

J. T. Tansey, C. Sztalryd, J. Gruia-gray, D. L. Roush, J. V. Zee et al., Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to dietinduced obesity, Proc Natl Acad Sci, vol.98, pp.6494-6499, 2001.

J. Tao, H. Y. Wang, and C. C. Malbon, Protein kinase A regulates AKAP250 (gravin) scaffold binding to the beta2-adrenergic receptor, EMBO J, vol.22, pp.6419-6429, 2003.

K. Tasken and E. M. Aandahl, Localized effects of cAMP mediated by distinct routes of protein kinase A, Physiol Rev, vol.84, pp.137-167, 2004.

H. Tornqvist and P. Belfrage, Purification and some properties of a monoacylglycerol-hydrolyzing enzyme of rat adipose tissue, J Biol Chem, vol.251, pp.813-819, 1976.

R. H. Unger, Minireview: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome, Endocrinology, vol.144, pp.5159-5165, 2003.

J. A. Villena, S. Roy, E. Sarkadi-nagy, K. H. Kim, and H. S. Sul, Desnutrin, an adipocyte gene encoding a novel patatin domaincontaining protein, is induced by fasting and glucocorticoids: ectopic expression of desnutrin increases triglyceride hydrolysis, J Biol Chem, vol.279, pp.47066-47075, 2004.

S. P. Wang, N. Laurin, J. Himms-hagen, M. A. Rudnicki, E. Levy et al., The adipose tissue phenotype of hormone-sensitive lipase deficiency in mice, Obes Res, vol.9, pp.119-128, 2001.

W. Wong and J. D. Scott, AKAP signalling complexes: focal points in space and time, Nat Rev Mol Cell Biol, vol.5, pp.959-970, 2004.

D. Zhang, C. Lu, M. Whiteman, B. Chance, and J. S. Armstrong, The mitochondrial permeability transition regulates cytochrome c release for apoptosis during endoplasmic reticulum stress by remodeling the cristae junction, J Biol Chem, vol.283, pp.3476-3486, 2008.

J. Zhang, C. J. Hupfeld, S. S. Taylor, J. M. Olefsky, and R. Y. Tsien, Insulin disrupts beta-adrenergic signalling to protein kinase A in adipocytes, Nature, vol.437, pp.569-573, 2005.

R. Zimmermann, G. Haemmerle, E. M. Wagner, J. G. Strauss, D. Kratky et al., Decreased fatty acid esterification compensates for the reduced lipolytic activity in hormone-sensitive lipasedeficient white adipose tissue, J Lipid Res, vol.44, pp.2089-2099, 2003.

R. Zimmermann, J. G. Strauss, G. Haemmerle, G. Schoiswohl, R. Birner-gruenberger et al., Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase, Science, vol.306, pp.1383-1386, 2004.