OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28, Nat Genet, vol.26, pp.211-215, 2000. ,
OPA1 disease alleles causing dominant optic atrophy have defects in cardiolipin-stimulated GTP hydrolysis and membrane tubulation, Hum Mol Genet, vol.19, pp.2113-2122, 2010. ,
Two classes of cAMP analogs which are selective for the two different cAMP-binding sites of type II protein kinase demonstrate synergism when added together to intact adipocytes, J Biol Chem, vol.259, pp.3539-3547, 1984. ,
Perilipin is located on the surface layer of intracellular lipid droplets in adipocytes, J Lipid Res, vol.36, pp.1211-1226, 1995. ,
A guided tour into subcellular colocalization analysis in light microscopy, J Microsc, vol.224, pp.213-232, 2006. ,
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Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-L1 adipocytes, J Biol Chem, vol.279, pp.46835-46842, 2004. ,
The lipolytic stimulation of 3T3-L1 adipocytes promotes the translocation of hormone-sensitive lipase to the surfaces of lipid storage droplets, Biochim Biophys Acta, vol.1483, pp.251-262, 2000. ,
Perilipin A increases triacylglycerol storage by decreasing the rate of triacylglycerol hydrolysis, J Biol Chem, vol.275, pp.38486-38493, 2000. ,
Identification and characterization of D-AKAP1 as a major adipocyte PKA and PP1 binding protein, Biochem Biophys Res Commun, vol.346, pp.351-357, 2006. ,
Delineation of type I protein kinase A-selective signaling events using an RI anchoring disruptor, J Biol Chem, vol.281, pp.21535-21545, 2006. ,
Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain, J Biol Chem, vol.267, pp.13376-13382, 1992. ,
FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance, Cell, vol.106, pp.563-573, 2001. ,
Characterization of RII(beta) and D-AKAP1 in differentiated adipocytes, Am J Physiol Cell Physiol, vol.282, pp.205-212, 2002. ,
OPA1 requires mitofusin 1 to promote mitochondrial fusion, Proc Natl Acad Sci, vol.101, pp.15927-15932, 2004. ,
Genetically lean mice result from targeted disruption of the RII beta subunit of protein kinase A, Nature, vol.382, pp.622-626, 1996. ,
Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy, Nat Genet, vol.26, pp.207-210, 2000. ,
AKAP signaling complexes at the cytoskeleton, J Cell Sci, vol.114, pp.1431-1437, 2001. ,
The consequences of introducing an autophosphorylation site into the type I regulatory subunit of cAMP-dependent protein kinase, J Biol Chem, vol.264, pp.9807-9813, 1989. ,
Role of semicarbazide-sensitive amine oxidase on glucose transport and GLUT4 recruitment to the cell surface in adipose cells, J Biol Chem, vol.273, pp.8025-8032, 1998. ,
Adrenergic regulation of adipocyte metabolism, J Lipid Res, vol.24, pp.945-966, 1983. ,
Assembly of an A kinase-anchoring protein-beta(2)-adrenergic receptor complex facilitates receptor phosphorylation and signaling, Curr Biol, vol.10, pp.409-412, 2000. ,
Hormone-sensitive lipase and monoacylglycerol lipase are both required for complete degradation of adipocyte triacylglycerol, Biochim Biophys Acta, vol.876, pp.288-293, 1986. ,
OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion, Cell, vol.126, pp.177-189, 2006. ,
Lipolytic activity of adipose tissue. IV. The diacylglycerol lipase activity of human adipose tissue, Biochim Biophys Acta, vol.369, pp.25-33, 1974. ,
Molecular basis of AKAP specificity for PKA regulatory subunits, Mol Cell, vol.24, pp.383-395, 2006. ,
Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets, J Biol Chem, vol.266, pp.11341-11346, 1991. ,
Isolation of cDNAs for perilipins A and B: sequence and expression of lipid droplet-associated proteins of adipocytes, Proc Natl Acad Sci, vol.90, pp.12035-12039, 1993. ,
Hormone-sensitive lipase deficiency in mice causes diglyceride accumulation in adipose tissue, muscle, and testis, J Biol Chem, vol.277, pp.4806-4815, 2002. ,
Overlay, ligand blotting, and band-shift techniques to study kinase anchoring, Methods Mol Biol, vol.88, pp.47-64, 1998. ,
Analysis of A-kinase anchoring protein (AKAP) interaction with protein kinase A (PKA) regulatory subunits: PKA isoform specificity in AKAP binding, J Mol Biol, vol.298, pp.329-339, 2000. ,
Regulation of mitochondrial morphology through proteolytic cleavage of OPA1, EMBO J, vol.25, pp.2966-2977, 2006. ,
Dual specificity A-kinase anchoring proteins (AKAPs) contain an additional binding region that enhances targeting of protein kinase A type I, J Biol Chem, vol.283, pp.33708-33718, 2008. ,
Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities, J Biol Chem, vol.279, pp.48968-48975, 2004. ,
Unraveling the mechanism of action of thiazolidinediones, J Clin Invest, vol.106, pp.1305-1307, 2000. ,
Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular, lipid storage droplet proteins, J Lipid Res, vol.51, pp.468-471, 2009. ,
A dynamic mechanism for AKAP binding to RII isoforms of cAMP-dependent protein kinase, Mol Cell, vol.24, pp.397-408, 2006. ,
Possible role of mitochondrial remodelling on cellular triacylglycerol accumulation, J Biochem, vol.146, pp.787-796, 2009. ,
Perilipins, ADRP, and other proteins that associate with intracellular neutral lipid droplets in animal cells, Semin Cell Dev Biol, vol.10, pp.51-58, 1999. ,
AKAP mediated signal transduction, Annu Rev Pharmacol Toxicol, vol.42, pp.235-257, 2002. ,
Primary structure of a dynamin-related mouse mitochondrial GTPase and its distribution in brain, subcellular localization, and effect on mitochondrial morphology, J Biol Chem, vol.277, pp.15834-15842, 2002. ,
Possible mechanisms by which adipocyte lipolysis is enhanced in exercise-trained rats, Biochem Biophys Res Commun, vol.295, pp.236-242, 2002. ,
Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis, J Biol Chem, vol.278, pp.7743-7746, 2003. ,
The human dynamin-related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter-membrane space, FEBS Lett, vol.523, pp.171-176, 2002. ,
Targeted disruption of hormone-sensitive lipase results in male sterility and adipocyte hypertrophy, but not in obesity, Proc Natl Acad Sci, vol.97, pp.787-792, 2000. ,
Knockdown of human COX17 affects assembly and supramolecular organization of cytochrome c oxidase, J Mol Biol, vol.389, pp.470-479, 2009. ,
Specificity and spatial dynamics of PKA signaling organized by A kinase anchoring proteins, J Mol Endocrinol, vol.44, pp.271-284, 2010. ,
Microheterogeneity of type II cAMP-dependent protein kinase in various mammalian species and tissues, J Biol Chem, vol.259, pp.10596-10605, 1984. ,
Inhibition of T cell activation by cyclic adenosine 5 0 -monophosphate requires lipid raft targeting of protein kinase A type I by the A-kinase anchoring protein ezrin, J Immunol, vol.179, pp.5159-5168, 2007. ,
Differential sublocalization of the dynamin-related protein OPA1 isoforms in mitochondria, Biochem Biophys Res Commun, vol.300, pp.482-493, 2003. ,
Mgm1p, a dynamin-related GTPase, is essential for fusion of the mitochondrial outer membrane, Mol Biol Cell, vol.14, pp.2342-2356, 2003. ,
Carboxylesterase 3 (EC 3.1.1.1) is a major adipocyte lipase, J Biol Chem, vol.279, pp.40683-40689, 2004. ,
Modulation of hormone-sensitive lipase and protein kinase Amediated lipolysis by perilipin A in an adenoviral reconstituted system, J Biol Chem, vol.277, pp.8267-8272, 2002. ,
A novel deletion in the GTPase domain of OPA1 causes defects in mitochondrial morphology and distribution, but not in function, Hum Mol Genet, vol.17, pp.3291-3302, 2008. ,
Characterization of A-kinase-anchoring disruptors using a solution-based assay, Biochem J, vol.400, pp.493-499, 2006. ,
Hydrophobic sequences target and anchor perilipin A to lipid droplets, J Lipid Res, vol.45, pp.1983-1991, 2004. ,
Functional studies on native and mutated forms of perilipins. A role in protein kinase A-mediated lipolysis of triacylglycerols, J Biol Chem, vol.278, pp.8401-8406, 2003. ,
Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to dietinduced obesity, Proc Natl Acad Sci, vol.98, pp.6494-6499, 2001. ,
Protein kinase A regulates AKAP250 (gravin) scaffold binding to the beta2-adrenergic receptor, EMBO J, vol.22, pp.6419-6429, 2003. ,
Localized effects of cAMP mediated by distinct routes of protein kinase A, Physiol Rev, vol.84, pp.137-167, 2004. ,
Purification and some properties of a monoacylglycerol-hydrolyzing enzyme of rat adipose tissue, J Biol Chem, vol.251, pp.813-819, 1976. ,
Minireview: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome, Endocrinology, vol.144, pp.5159-5165, 2003. ,
Desnutrin, an adipocyte gene encoding a novel patatin domaincontaining protein, is induced by fasting and glucocorticoids: ectopic expression of desnutrin increases triglyceride hydrolysis, J Biol Chem, vol.279, pp.47066-47075, 2004. ,
The adipose tissue phenotype of hormone-sensitive lipase deficiency in mice, Obes Res, vol.9, pp.119-128, 2001. ,
AKAP signalling complexes: focal points in space and time, Nat Rev Mol Cell Biol, vol.5, pp.959-970, 2004. ,
The mitochondrial permeability transition regulates cytochrome c release for apoptosis during endoplasmic reticulum stress by remodeling the cristae junction, J Biol Chem, vol.283, pp.3476-3486, 2008. ,
Insulin disrupts beta-adrenergic signalling to protein kinase A in adipocytes, Nature, vol.437, pp.569-573, 2005. ,
Decreased fatty acid esterification compensates for the reduced lipolytic activity in hormone-sensitive lipasedeficient white adipose tissue, J Lipid Res, vol.44, pp.2089-2099, 2003. ,
Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase, Science, vol.306, pp.1383-1386, 2004. ,