Skip to Main content Skip to Navigation
Journal articles

Review: Human trophoblast fusion and differentiation: Lessons from trisomy 21 placenta

Abstract : The syncytiotrophoblast layer plays a major role throughout pregnancy, since it is the site of numerous placental functions, including ion and nutrient exchange and the synthesis of steroid and peptide hormones required for fetal growth and development. Inadequate formation and regeneration of this tissue contributes to several pathologies of pregnancy such as intrauterine growth restriction and preeclampsia, which may lead to iatrogenic preterm delivery in order to prevent fetal death and maternal complications. Syncytiotrophoblast formation can be reproduced in vitro using different models. For the last ten years we have routinely purified villous cytotrophoblastic cells (CT) from normal first, second and third trimester placentas and from gestational age-matched Trisomy 21 placentas. We cultured villous CT on plastic dishes to follow the molecular and biochemical aspects of their morphological and functional differentiation. Taking advantage of this unique collection of samples, we here discuss the concept that trophoblast fusion and functional differentiation may be two differentially regulated processes, which are linked but quite distinct. We highlight the major role of mesenchymal-trophoblast cross talk in regulating trophoblast cell fusion. We suggest that the oxidative status of the trophoblast may regulate glycosylation of proteins, including hCG, and thereby modulate major trophoblast cell functions.
Complete list of metadatas

Cited literature [52 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-02556136
Contributor : Guillaume Pidoux <>
Submitted on : Monday, April 27, 2020 - 6:34:08 PM
Last modification on : Thursday, April 30, 2020 - 1:40:02 AM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

Citation

Guillaume Pidoux, Pascale Gerbaud, Mélanie Cocquebert, Nadine Segond, Josette Badet, et al.. Review: Human trophoblast fusion and differentiation: Lessons from trisomy 21 placenta. Placenta, Elsevier, 2012, 33, Suppl:S81-86. ⟨10.1016/j.placenta.2011.11.007⟩. ⟨inserm-02556136⟩

Share

Metrics

Record views

43