T. M. Lin, S. P. Halbert, D. Kiefer, W. N. Spellacy, and S. Gall, Characterization of four human pregnancy-associated plasma proteins, Am J Obstet Gynecol, vol.118, pp.223-236, 1974.

M. T. Overgaard, C. Oxvig, M. Christiansen, J. B. Lawrence, C. A. Conover et al., Messenger acid levels of pregnancy associated plasma protein A and the proform of eosinophil major basic protein: expression in human reproductive and non reproductive tissues, Biol Reprod, vol.61, pp.1083-9108, 1999.

L. C. Giudice, C. A. Conover, L. Bale, G. H. Faessen, K. Ilg et al., Identification and regulation of IGFBP-4 protease and its physiological inhibitor in human trophoblasts and endometrial stroma: evidence for paracrine regulation of IGF-II bioavailability in the placental bed during human implantation, J Clin Endocrinol Metab, vol.87, pp.1359-1366, 2002.

P. D'elia, D. Marzioni, M. Castellucci, C. Mocci, and A. Pala, Homodimeric pregnancy-associated plasma protein-A in normal human placenta of first and third trimester of pregnancy: biochemical and morphological observations, Placenta, vol.33, pp.942-945, 2012.

A. Coskun, M. Serteser, S. Duran, T. C. Inal, B. E. Erdogan et al., Unsal I: Reference interval of pregnancy-associated plasma protein-a in healthy men and non-pregnant women, J Cardiol, vol.61, pp.128-131, 2013.

A. Bayes-genis, C. A. Conover, M. T. Overgaard, K. R. Bailey, M. Christiansen et al., Pregnancy-associated plasma protein A as a marker of acute coronary syndromes, N Engl J Med, vol.345, pp.1022-1029, 2001.

L. Consuegra-sanchez, S. Fredericks, and J. C. Kaski, Pregnancy-associated plasma protein-A (PAPP-A) and cardiovascular risk, Atherosclerosis, vol.203, pp.346-352, 2009.

C. Oxvig, O. Sand, T. Kristensen, G. J. Gleich, and L. Sottrup-jensen, Circulating human pregnancy-associated plasma protein A is disulfide-bridged to the proform of eosinophil major basic protein, J Biol Chem, vol.268, pp.12243-12246, 1993.

J. G. Westergaard, B. Teisner, J. Chemnitz, and J. G. Grudzinkas, Serum PAPP-A in normal pregnancy: relationship to fetal and maternal characteristics, Arch Gynecol, vol.233, pp.211-215, 1983.

I. Kirkegaard, N. Uldbjerg, and C. Oxvig, Biology of pregnancy-associated plasma protein-A in relation to prenatal diagnostics: an overview, Acta Obstet Gynecol Scand, vol.89, pp.1118-1125, 2010.

L. Dugoff, J. C. Hobbins, F. D. Malone, T. F. Porter, D. Luthy et al., Alton ME: First trimester maternal serum PAPP-A and free-beta subunit human chorionic gonadotropin concentrations and nuchal translucency are associated with obstetric complications: a population-based screening study (the FASTER Trial), Am J Obstet Gynecol, vol.191, pp.1446-1451, 2004.

J. K. Ranta, K. Raatikainen, J. Romppanen, K. Pulkki, and S. Heinonen, Decreased PAPP-A is associated with preeclampsia, premature delivery and small for gestational age infants but not with placental abruption, Eur J Obstet Gynecol Reprod Biol, vol.157, pp.48-52, 2011.

N. A. Bersinger, M. L. Brizot, A. Johnson, R. J. Snijders, J. Abbott et al., First trimester maternal serum pregnancy-associated plasma protein A and pregnancy-specific ?1-glycoprotein in fetal trisomies, Br J Obstet Gynaecol, vol.101, pp.970-974, 1994.

J. E. Haddow, G. E. Palomaki, G. J. Knight, J. Williams, W. A. Miller et al., Screening of maternal serum for fetal Down's syndrome in the first trimester, N Engl J Med, vol.338, pp.955-961, 1998.

Y. Ville, How to improve the screening and diagnosis of fetal aneuploidy?, Bull Acad Med, vol.189, pp.1773-1784, 2005.

K. Spencer, First trimester maternal serum screening for Down's syndrome: an evaluation of the DPC Immulite 2000 free beta-hCG and pregnancy protein-A assays, Ann Clin Biochem, vol.42, pp.30-40, 2005.

H. J. Klinman, J. E. Nestler, E. Sermasi, J. M. Sanger, and J. F. Strauss, Purification, characterization, and in vitro differentiation of cytotrophoblasts from human term placentae, Endocrinology, vol.118, pp.1567-1582, 1986.

J. Guibourdenche, E. Alsat, F. Soncin, R. , and C. , Evain-Brion D: Retinoid receptors expression in human term placenta: involvement of RXR alpha in retinoid induced-hCG secretion, J Clin Endocrinol Metab, vol.83, pp.1384-1387, 1998.

K. Spencer, V. Souter, N. Tul, R. Snijders, and K. H. Nicolaides, A screening program for trisomy 21 at 10-14 weeks using fetal nuchal translucency, maternal serum free beta-human chorionic gonadotropin and pregnancy associated plasma protein A, Ultrasound Obstet Gynecol, vol.13, pp.231-237, 1999.

M. Grande, M. Arigita, V. Borobio, J. M. Jimenez, S. Fernandez et al., First trimester detection of structural abnormalities and the role of aneuploidy markers, Ultrasound Obstet Gynecol, vol.339, pp.157-163, 2012.

S. Shiefa, M. Amargandhi, J. Bhupendra, S. Moulali, and K. T. , First trimester maternal screening using biochemical markers PAPP-A and free ?-hCG for Down Syndrome, Patau Syndrome and Edward Syndrome, Indian J Clin Biochem, vol.28, pp.3-12, 2013.

R. Smith-bindman, W. Hosmer, V. A. Feldstein, J. J. Deeks, and J. D. Goldberg, Secondtrimester ultrasound to detect fetuses with Down syndrome: a metaanalysis, JAMA, vol.85, pp.1044-1055, 2001.

S. Lai, W. L. Lau, W. C. Leung, F. K. Lai, and R. Chin, Is ultrasound alone enough for prenatal screening of trisomy 18? A single center experience in 69 cases over 10 years, Prenat Diagn, vol.30, pp.1094-1099, 2010.

Z. Szigeti, A. Csaba, B. Pete, J. Hajdú, Z. Papp et al., Correlation of prenatal sonographic diagnosis and morphologic findings of fetal autopsy in fetuses with trisomy 21, J Ultrasound Med, vol.26, pp.61-68, 2007.

M. Jemmali, A. S. Valat, P. Poulain, R. Favre, P. Bourgeot et al., Nuchal tranlucency: screening for chromosomal abnormalities and congenital malformations. Multicenter study, J Gynecol Obstet Biol Reprod, vol.28, pp.538-543, 1999.

K. H. Nicolaides, Screening for fetal anuploidies at 11 to 13 weeks, Prenat Diagn, vol.31, pp.7-15, 2011.

N. Tul, K. Spencer, P. Noble, C. Chan, and K. Nicolaides, Screening for trisomy 18 by fetal nuchal translucency and maternal serum free beta-hCG and PAPP-A at 10-14 weeks of gestation, Prenat Diagn, vol.19, pp.1035-1042, 1999.

K. Spencer and K. H. Nicolaides, A first trimester trisomy 13/trisomy 18 risk algorithm combining fetal nuchal translucency thickness, maternal serum free ß -hCG and PAPP-A, Prenat Diagn, vol.22, pp.877-879, 2002.

K. H. Nicolaides, K. Spencer, K. Avgidou, S. Faiola, and O. Falcon, Multicenter study of first-trimester screening for trisomy 21 in 75 821 pregnancies: results and estimation of the potential impact of individual risk-orientated twostage first-trimester screening, Ultrasound Obstet Gynecol, vol.25, pp.221-226, 2005.

E. Jauniaux and J. Hustin, Chromosomally abnormal early ongoing pregnancies: correlation of ultrasound and placental histological findings, Hum Pathol, vol.29, pp.1195-1199, 1998.

S. Labbé, H. Copin, A. Choiset, S. Girard, and J. P. Barbet, The placenta and trisomies 13, vol.18, pp.989-996, 1989.

B. Rochelson, C. Kaplan, E. Guzman, M. Arato, K. Hansen et al., A quantitative analysis of placental vasculature in the third trimester fetus with autosomal trisomy, Obstet Gynecol, vol.75, pp.59-63, 1990.

L. Roberts, N. J. Sebire, D. Fowler, and K. H. Nicolaides, Histomorphological features of chorionic villi at 10-14 weeks of gestation in trisomic and chromosomally normal pregnancies, Placenta, vol.21, pp.678-683, 2000.

F. Queshsri, S. M. Jacques, M. P. Johnson, R. F. Hume, R. L. Kramer et al., Trisomy 21 placentas: histopathological and immunohistological finding using proliferating cell nuclear antigen, Fetal Diagn Ther, vol.12, pp.210-215, 1997.

T. Kristensen, C. Oxvig, O. Sand, L. Moller, and G. J. Sottrup-jensen, Amino acid sequence of human pregnancy-associated plasma protein A derived from cloned cDNA, Biochemistry, vol.33, pp.1592-1598, 1994.

M. T. Overgaard, J. Haaning, H. B. Boldt, I. M. Olsen, L. S. Laursen et al., Expression of recombinant human pregnancy-associated plasma protein-A and identification of the proform of eosinophil major basic protein as its physiological inhibitor, J Biol Chem, vol.275, pp.31128-31133, 2000.

L. S. Laursen, M. T. Overgaard, R. Soe, H. B. Boldt, L. Sottrup-jensen et al., Pregnancy-associated plasma protein-A (PAPP-A) cleaves insulin-like growth factor binding protein (IGFBP)-5 independent of IGF: implications for the mechanism of IGFBP-4 proteolysis by PAPP-A, FEBS Lett, vol.504, pp.36-40, 2001.

J. B. Lawrence, C. Oxvig, M. T. Overgaard, L. Sottrup-jensen, G. J. Gleich et al., The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancyassociated plasma protein A, Proc Natl Acad Sci U S A, vol.96, pp.3149-3153, 1999.

C. Oxvig, O. Sand, T. Kristensen, L. Kristensen, and L. Sottrup-jensen, Isolation and characterization of circulating complex between human pregnancyassociated plasma protein A and proform of eosinophil major basic protein, Biochim Biophys Acta, vol.1201, pp.415-423, 1994.

P. Bischof, S. Duberg, W. L. Herrmann, and P. C. Sizonenko, Amniotic fluid and plasma concentrations of pregnancy-associated plasma protein A (PAPP-A), Br J Obstet Gynaecol, vol.89, pp.701-703, 1982.

T. M. Lin, S. P. Halbert, D. Kiefer, and W. N. Spellacy, Measurement of pregnancy associated plasma proteins during human gestation, J Clin Invest, vol.54, pp.576-582, 1974.

J. Folkersen, J. G. Grudzinskas, P. Hindersson, B. Teisner, and J. Westergaard, Pregnancy-associated plasma protein A: circulating levels during normal pregnancy, Am J Obstet Gynecol, vol.139, pp.910-924, 1981.

K. Pihl, T. Larsen, S. Rasmussen, L. Krebs, and M. Christiansen, The proform of eosinophil major basic protein: a new maternal serum marker for adverse pregnancy outcome, Prenat Diagn, vol.29, pp.1013-1019, 2009.

D. Tornehave, J. Chemnitz, B. Teisner, J. Folkersen, and J. G. Westergaard, Immunohistochemical demonstration of pregnancy associated plasma protein A (PAPP-A) in the syncytiotrophoblast of the normal placenta at different gestational ages, Placenta, vol.5, pp.427-431, 1984.

A. M. Schindler, P. Bordignon, and P. Bischof, Immunohistochemical localization of pregnancy-associated plasma protein A in decidua and trophoblast: comparison with human chorionic gonadotrophin and fibrin, Placenta, vol.5, pp.227-236, 1984.

J. Chemnitz, J. Folkersen, B. Teisner, M. J. Sinosich, D. Tornehave et al., Comparison of different antibody preparations against pregnancy-associated plasma protein A (PAPP-A) for the use in localization and immunoassay studies, Br J Obstet Gynaecol, vol.93, pp.916-923, 1986.

M. Bonno, C. Oxvig, G. M. Kephart, J. M. Wagner, T. Kristensen et al., Localization of pregnancy-associated plasma protein A and colocalization of pregnancy-associated plasma protein A messenger ribonucleic acid and eosinophil granule major basic protein messenger ribonucleic acid in placenta, Lab Invest, vol.71, pp.560-566, 1994.

J. Guibourdenche, J. L. Frendo, G. Pidoux, G. Bertin, D. Luton et al., Evain-Brion D: Expression of pregnancy-associated plasma protein-A (PAPP-A) during villous trophoblast differentiation in vitro, Placenta, vol.24, pp.532-539, 2003.

L. K. Proctor, M. Toal, S. Keating, D. Chitayat, N. Okun et al., Placental size and the prediction of severe early-onset intrauterine growth restriction in women with low pregnancy associated plasma protein A, Ultrasound Obstet Gynecol, vol.34, pp.274-82, 2009.

M. Sahraravand, I. Y. Järvelä, P. Laitinen, A. H. Tekay, and M. Ryynänen, The secretion of PAPP-A, ADAM 12, and PP13 correlates with the size of the placenta for the first month of pregnancy, Placenta, vol.32, pp.999-1003, 2011.

A. O. Odibo, Y. Zhong, M. Longtime, M. Tuuli, L. Odibo et al., First trimester serum analytes, biophysical tests and the association with pathological morphometry in the placenta of pregnancies with preeclampsia and fetal growth restriction, Placenta, vol.32, pp.333-338, 2011.

J. L. Frendo, M. Vidaud, J. Guibourdenche, D. Luton, F. Muller et al., Evain-Brion D: Defect of villous cytotrophoblast differentiation into syncytiotrophoblast in Down's syndrome, J Clin Endocrinol Metab, vol.85, pp.3700-3707, 2000.

J. Guibourdenche, J. L. Frendo, G. Pidoux, M. Vidau, D. Luton et al., Evain-Brion D: Trophoblast production of a weakly bioactive human chorionic gonadotropin in Trisomy 21-affected pregnancy, J Clin Endocrinol Metab, vol.89, pp.727-732, 2004.

K. Handschuh, J. Guibourdenche, M. Guesnon, I. Laurendeau, D. Evain-brion et al., Modulation of PAPP-A expression by PPAR ? in human first trimester trophoblast, Placenta, vol.27, pp.127-134, 2006.

N. J. Sebire, D. Fowler, L. Roberts, S. Mahmood, and K. H. Nicolaides, Trophoblast proliferation is increased in chorionoic villi from pregnancies with fetal trisomy 18, Placenta, vol.21, pp.584-586, 2000.

A. Wright, Y. Zhou, F. Weler, E. Caceres, M. Kapidzic et al., Trisomy 21 is associated with variable defects in cytotrophoblast differentiation along the invasive pathway, Am J Med Genet, vol.130, pp.354-364, 2004.

L. C. Poon, T. Chelemen, R. Minekawa, V. Frisova, and K. H. Nicolaides, Maternal serum ADAM 12 (A disintegrin and metalloprotease) in chromosomally abnormal pregnancy at 11-13 weeks, Am J Obstet Gynecol, vol.200, pp.1-6, 2009.

G. Pidoux, P. Gerbaud, M. Cocquebert, N. Segon, J. Badet et al., Evain-Brion D: Human trophoblast fusion and differentiation : lessons from trisomy 21 placenta, Placenta, vol.33, pp.81-86, 2012.

B. Huppertz, D. Ghosh, and J. Sengupta, An integrative view on the physiology of human early placental villi, Prog Biophys Mol Biol, vol.114, pp.33-48, 2014.

. Leguy, Pattern of secretion of pregnancyassociated plasma protein-A (PAPP-A) during pregnancies complicated by fetal aneuploidy, in vivo and in vitro, Reproductive Biology and Endocrinology, vol.12, p.129, 2014.
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