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Adjunct immunotherapies for the management of severely ill COVID-19 patients

Abstract : Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It has infected millions with more than 181,000 fatal cases as of 22nd April 2020. Currently, there are no specific COVID-19 therapies. Most patients depend on mechanical ventilation. Current COVID-19 data clearly highlight that cytokine storm and activated immune cell migration to the lungs characterize the early immune response to COVID19 that causes severe lung damage and development of acute respiratory distress syndrome. In view of uncertainty associated with immunosuppressive treatments such as corticosteroids and their possible secondary effects, including risks of secondary infections, we suggest immunotherapies as an adjunct therapy in severe COVID-19 cases. Such immunotherapies based on inflammatory cytokine neutralization, immunomodulation and passive viral neutralization, not only reduce inflammation, inflammation-associated lung damage, or viral load, but could also prevent intensive care unit hospitalization and dependency on mechanical ventilation both of which are limited resources.
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https://www.hal.inserm.fr/inserm-02555342
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Submitted on : Friday, May 1, 2020 - 12:59:27 PM
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Srinivasa Reddy Bonam, Srini Kaveri, Anavaj Sakuntabhai, Laurent Gilardin, Jagadeesh Bayry. Adjunct immunotherapies for the management of severely ill COVID-19 patients. Cell Reports Medicine, Cell Press, 2020, 1 (2), pp.100016. ⟨10.1016/j.xcrm.2020.100016⟩. ⟨inserm-02555342v2⟩

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