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Correlation between blood telomere length and CD4+ CD8+ T-cell subsets changes 96 weeks after initiation of antiretroviral therapy in HIV-1–positive individuals

Mathieu Chalouni 1 Javier Rodriguez-Centeno 2 Assia Samri 3 Julian Blanco 4 Natalia Stella-Ascariz 2 Cedrick Wallet 5 Hernando Knobel 6 David Zucman 7 Belen Alejos Ferreras 8 Brigitte Autran 3 Rodolphe Thiébaut 1 François Raffi 9 Jose Ramon Arribas 2, *
* Corresponding author
1 BPH - Bordeaux population health
2 Hospital La Paz Institute for Health Research [Madrid, Espagne]
3 CIMI - Centre d'Immunologie et de Maladies Infectieuses
4 Germans Trias i Pujol University Hospital [Badalone, Espagne]
5 Epidemiologie-Biostatistique [Bordeaux]
6 Hospital del Mar [Barcelone, Espagne]
7 Service de Médecine Interne [Suresnes]
8 Institute of Health Carlos III
9 Infectious Diseases Department [Nantes]
Abstract : In 31 participants who started first-line antiretroviral therapy in the NEAT 001/ANRS 143 clinical trial, we found after 96 weeks a statistically significant increase in blood telomere length (TL) of 0.04 (T/S Ratio) (p = 0.03). This increase was positively correlated with both the change in the percentage of CD4+ T-cells and with the decrease of CD38+ molecules on Central Memory CD8+ and negatively correlated with the change in the percentage of CD4+ Effector Memory cells. Increase in TL could be an expression of immune reconstitution and the associated decrease in immune activation. We acknowledge for the low statistical power due to the small sample size and the potential for false positive results due to multiple testing. Hence, further studies are needed to confirm these observations.
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Submitted on : Wednesday, April 15, 2020 - 3:34:28 PM
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Mathieu Chalouni, Javier Rodriguez-Centeno, Assia Samri, Julian Blanco, Natalia Stella-Ascariz, et al.. Correlation between blood telomere length and CD4+ CD8+ T-cell subsets changes 96 weeks after initiation of antiretroviral therapy in HIV-1–positive individuals. PLoS ONE, Public Library of Science, 2020, 15 (4), pp.e0230772. ⟨10.1371/journal.pone.0230772⟩. ⟨inserm-02543732⟩

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