Skip to Main content Skip to Navigation
Journal articles

Host-Range shift between emerging P[8]-4 Rotavirus and Common P[8] and P[4] Strains: Host-range shift of P[8] rotaviruses

Abstract : In Tunisia, we observed that rotavirus P[8]-3 and P[4] in young children with gastroenteritis associate with the secretor histo-blood-group phenotype. Inversely, the emerging P[8]-4, representing 10% of cases, was exclusively found among nonsecretor patients. Unlike VP8* from P[8]-3 and P[4] strains, the P[8]-4 VP8* protein attached to glycans from saliva samples regardless of the donors Secretor status. Interestingly, a high frequency of FUT2 enzyme deficiency (nonsecretor phenotype) was observed in the population. This may allow co-circulation of P[8]-3 and P[8]-4 strains in secretor and nonsecretor children, respectively.
Complete list of metadatas

Cited literature [18 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-02541930
Contributor : Elizabeth Bernardo <>
Submitted on : Tuesday, April 14, 2020 - 11:47:55 AM
Last modification on : Wednesday, April 15, 2020 - 1:46:25 AM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : 2020-09-19

Please log in to resquest access to the document

Identifiers

Collections

Citation

Amira Khachou, Béatrice Le Moullac-Vaidye, Cécile Peltier, Adrien Breiman, Marie Imbert-Marcille, et al.. Host-Range shift between emerging P[8]-4 Rotavirus and Common P[8] and P[4] Strains: Host-range shift of P[8] rotaviruses. Journal of Infectious Diseases and Therapy, Omics Publishing Group, 2020, pp.jiaa122. ⟨10.1093/infdis/jiaa122⟩. ⟨inserm-02541930⟩

Share

Metrics

Record views

39