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A Shared Regulatory Element Controls the Initiation of Tcf7 Expression During Early T Cell and Innate Lymphoid Cell Developments

Abstract : The transcription factor TCF-1 (encoded by Tcf7) plays critical roles in several lineages of hematopoietic cells. In this study, we examined the molecular basis for Tcf7 regulation in T cells, innate lymphoid cells, and migratory conventional dendritic cells that we find express Tcf7. We identified a 1 kb regulatory element crucial for the initiation of Tcf7 expression in T cells and innate lymphoid cells, but dispensable for Tcf7 expression in Tcf7-expressing dendritic cells. Within this region, we identified a Notch binding site important for the initiation of Tcf7 expression in T cells but not in innate lymphoid cells. Our work establishes that the same regulatory element is used by distinct transcriptional controllers to initiate Tcf7 expression in T cells and ILCs.
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https://www.hal.inserm.fr/inserm-02541580
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Submitted on : Tuesday, April 14, 2020 - 8:11:13 AM
Last modification on : Tuesday, May 26, 2020 - 10:08:02 PM

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Christelle Harly, Devin Kenney, Yueqiang Wang, Yi Ding, Yongge Zhao, et al.. A Shared Regulatory Element Controls the Initiation of Tcf7 Expression During Early T Cell and Innate Lymphoid Cell Developments. Frontiers in Immunology, Frontiers, 2020, 11, pp.470. ⟨10.3389/fimmu.2020.00470⟩. ⟨inserm-02541580⟩

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